Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-31 | Eastern Oregon | 0 | 0 | Gonzaga (1) | Cancelled | - | - |
| 2 | 2021-11-05 | Lewis & Clark | 62 | 112 | Gonzaga (1) | Final | W | 50 |
| 3 | 2021-11-09 | Dixie State (302) | 63 | 97 | Gonzaga (1) | Final | W | 34 |
| 4 | 2021-11-13 | Texas (10) | 74 | 86 | Gonzaga (1) | Final | W | 12 |
| 5 | 2021-11-15 | Alcorn State (343) | 57 | 84 | Gonzaga (3) | Final | W | 27 |
| 6 | 2021-11-19 | Bellarmine (266) | 50 | 92 | Gonzaga (11) | Final | W | 42 |
| 7 | 2021-11-22 | Gonzaga (11) | 107 | 54 | Central Michigan (311) | Final | W | 53 |
| 8 | 2021-11-23 | Gonzaga (18) | 83 | 63 | UCLA (13) | Final | W | 20 |
| 9 | 2021-11-26 | Gonzaga (11) | 81 | 84 | Duke (3) | Final | L | -3 |
| 10 | 2021-11-29 | Tarleton State (307) | 55 | 64 | Gonzaga (7) | Final | W | 9 |
| 11 | 2021-12-04 | Alabama (15) | 91 | 82 | Gonzaga (11) | Final | L | -9 |
| 12 | 2021-12-09 | Merrimack (271) | 55 | 80 | Gonzaga (22) | Final | W | 25 |
| 13 | 2021-12-12 | Washington (72) | 0 | 0 | Gonzaga (11) | Cancelled | - | - |
| 14 | 2021-12-18 | Texas Tech (20) | 55 | 69 | Gonzaga (11) | Final | W | 14 |
| 15 | 2021-12-20 | Northern Arizona (324) | 49 | 95 | Gonzaga (11) | Final | W | 46 |
| 16 | 2021-12-28 | North Alabama (335) | 63 | 93 | Gonzaga (11) | Final | W | 30 |
| 17 | 2021-12-30 | Gonzaga (11) | 0 | 0 | San Diego (246) | Postponed | - | - |
| 18 | 2022-01-01 | Gonzaga (11) | 0 | 0 | Loyola Marymount (184) | Canceled | - | - |
| 19 | 2022-01-08 | Pepperdine (283) | 83 | 117 | Gonzaga (11) | Final | W | 34 |
| 20 | 2022-01-13 | BYU (23) | 84 | 110 | Gonzaga (11) | Final | W | 26 |
| 21 | 2022-01-15 | Gonzaga (11) | 115 | 83 | Santa Clara (42) | Final | W | 32 |
| 22 | 2022-01-20 | San Francisco (122) | 62 | 78 | Gonzaga (11) | Final | W | 16 |
| 23 | 2022-01-27 | Loyola Marymount (184) | 55 | 89 | Gonzaga (11) | Final | W | 34 |
| 24 | 2022-01-29 | Portland (210) | 72 | 104 | Gonzaga (11) | Final | W | 32 |
| 25 | 2022-02-03 | Gonzaga (11) | 92 | 62 | San Diego (246) | Final | W | 30 |
| 26 | 2022-02-05 | Gonzaga (11) | 90 | 57 | BYU (23) | Final | W | 33 |
| 27 | 2022-02-10 | Pacific (132) | 51 | 89 | Gonzaga (11) | Final | W | 38 |
| 28 | 2022-02-12 | Saint Mary's (33) | 58 | 74 | Gonzaga (11) | Final | W | 16 |
| 29 | 2022-02-16 | Gonzaga (2) | 86 | 66 | Pepperdine (286) | Final | W | 20 |
| 30 | 2022-02-19 | Santa Clara (74) | 69 | 81 | Gonzaga (2) | Final | W | 12 |
| 31 | 2022-02-24 | Gonzaga (1) | 89 | 73 | San Francisco (38) | Final | W | 16 |
| 32 | 2022-02-26 | Gonzaga (1) | 57 | 67 | Saint Mary's (27) | Final | L | -10 |
| 33 | 2022-03-07 | San Francisco (33) | 71 | 81 | Gonzaga (2) | Final | W | 10 |
| 34 | 2022-03-08 | Saint Mary's (21) | 69 | 82 | Gonzaga (2) | Final | W | 13 |
| 35 | 2022-03-17 | Georgia State (146) | 72 | 93 | Gonzaga (2) | Final | W | 21 |
| 36 | 2022-03-19 | Memphis (40) | 78 | 82 | Gonzaga (2) | Final | W | 4 |
| 37 | 2022-03-24 | Arkansas (18) | 74 | 68 | Gonzaga (2) | Final | L | -6 |