Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Gardner-Webb (256) | 58 | 64 | UNLV (169) | Final | L | -6 |
| 2 | 2021-11-13 | Gardner-Webb (256) | 69 | 86 | Arkansas (8) | Final | L | -17 |
| 3 | 2021-11-16 | Gardner-Webb (296) | 52 | 92 | Duke (1) | Final | L | -40 |
| 4 | 2021-11-20 | Carver Bible | 38 | 100 | Gardner-Webb (296) | Final | W | 62 |
| 5 | 2021-11-24 | Columbia International | 78 | 90 | Gardner-Webb (363) | Final | W | 12 |
| 6 | 2021-11-27 | Western Carolina (224) | 59 | 87 | Gardner-Webb (259) | Final | W | 28 |
| 7 | 2021-11-29 | North Carolina Central (289) | 58 | 83 | Gardner-Webb (193) | Final | W | 25 |
| 8 | 2021-12-04 | Gardner-Webb (363) | 52 | 62 | East Carolina (252) | Final | L | -10 |
| 9 | 2021-12-08 | Wofford (128) | 78 | 70 | Gardner-Webb (192) | Final | L | -8 |
| 10 | 2021-12-11 | Gardner-Webb (363) | 61 | 64 | Virginia Military (357) | Final | L | -3 |
| 11 | 2021-12-15 | Gardner-Webb (363) | 71 | 72 | North Carolina Central (341) | Final | L | -1 |
| 12 | 2021-12-17 | Converse | 46 | 79 | Gardner-Webb (363) | Final | W | 33 |
| 13 | 2021-12-29 | Gardner-Webb (363) | 77 | 60 | Georgia (35) | Final | W | 17 |
| 14 | 2022-01-05 | Gardner-Webb (363) | 88 | 63 | Charleston Southern (262) | Final | W | 25 |
| 15 | 2022-01-08 | Hampton (260) | 69 | 78 | Gardner-Webb (363) | Final | W | 9 |
| 16 | 2022-01-12 | Presbyterian (249) | 61 | 64 | Gardner-Webb (211) | Final | W | 3 |
| 17 | 2022-01-15 | Gardner-Webb (363) | 60 | 66 | Longwood (269) | Final | L | -6 |
| 18 | 2022-01-19 | South Carolina Upstate (293) | 74 | 61 | Gardner-Webb (363) | Final | L | -13 |
| 19 | 2022-01-22 | Gardner-Webb (363) | 62 | 64 | Winthrop (133) | Final | L | -2 |
| 20 | 2022-01-27 | Gardner-Webb (363) | 61 | 55 | UNC-Asheville (244) | Final | W | 6 |
| 21 | 2022-01-29 | Radford (255) | 42 | 61 | Gardner-Webb (363) | Final | W | 19 |
| 22 | 2022-02-02 | Gardner-Webb (213) | 65 | 57 | High Point (264) | Final | W | 8 |
| 23 | 2022-02-05 | North Carolina A&T (294) | 62 | 69 | Gardner-Webb (363) | Final | W | 7 |
| 24 | 2022-02-09 | Gardner-Webb (363) | 57 | 45 | Campbell (191) | Final | W | 12 |
| 25 | 2022-02-12 | Charleston Southern (262) | 65 | 82 | Gardner-Webb (363) | Final | W | 17 |
| 26 | 2022-02-16 | Winthrop (161) | 81 | 70 | Gardner-Webb (186) | Final | L | -11 |
| 27 | 2022-02-19 | Gardner-Webb (186) | 76 | 68 | Presbyterian (257) | Final | W | 8 |
| 28 | 2022-02-23 | UNC-Asheville (221) | 59 | 60 | Gardner-Webb (189) | Final | W | 1 |
| 29 | 2022-02-26 | Gardner-Webb (189) | 70 | 72 | South Carolina Upstate (247) | Final | L | -2 |
| 30 | 2022-03-04 | Campbell (229) | 53 | 54 | Gardner-Webb (195) | Final | W | 1 |
| 31 | 2022-03-05 | Gardner-Webb (195) | 67 | 76 | Winthrop (135) | Final | L | -9 |