Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | North Florida (301) | 74 | 89 | Texas Tech (24) | Final | W | 15 |
| 2 | 2021-11-12 | Grambling (312) | 62 | 88 | Texas Tech (20) | Final | W | 26 |
| 3 | 2021-11-15 | Prairie View A&M (349) | 49 | 84 | Texas Tech (84) | Final | W | 35 |
| 4 | 2021-11-20 | Texas Tech (20) | 84 | 62 | Incarnate Word (280) | Final | W | 22 |
| 5 | 2021-11-23 | Nebraska-Omaha (345) | 40 | 96 | Texas Tech (73) | Final | W | 56 |
| 6 | 2021-11-27 | Lamar (347) | 57 | 89 | Texas Tech (73) | Final | W | 32 |
| 7 | 2021-12-01 | Texas Tech (20) | 68 | 72 | Providence (82) | Final | L | -4 |
| 8 | 2021-12-07 | Texas Tech (20) | 57 | 52 | Tennessee (18) | Final/OT | W | 5 |
| 9 | 2021-12-14 | Arkansas State (147) | 62 | 75 | Texas Tech (20) | Final | W | 13 |
| 10 | 2021-12-18 | Texas Tech (20) | 55 | 69 | Gonzaga (11) | Final | L | -14 |
| 11 | 2021-12-22 | Eastern Washington (242) | 46 | 78 | Texas Tech (20) | Final | W | 32 |
| 12 | 2021-12-28 | Alabama State (331) | 53 | 75 | Texas Tech (20) | Final | W | 22 |
| 13 | 2022-01-01 | Oklahoma State (57) | 0 | 0 | Texas Tech (20) | Postponed | - | - |
| 14 | 2022-01-05 | Texas Tech (20) | 47 | 51 | Iowa State (7) | Final | L | -4 |
| 15 | 2022-01-08 | Kansas (19) | 67 | 75 | Texas Tech (20) | Final | W | 8 |
| 16 | 2022-01-11 | Texas Tech (20) | 65 | 62 | Baylor (58) | Final | W | 3 |
| 17 | 2022-01-13 | Oklahoma State (57) | 57 | 78 | Texas Tech (20) | Final | W | 21 |
| 18 | 2022-01-15 | Texas Tech (20) | 51 | 62 | Kansas State (96) | Final | L | -11 |
| 19 | 2022-01-18 | Iowa State (7) | 60 | 72 | Texas Tech (20) | Final | W | 12 |
| 20 | 2022-01-22 | West Virginia (50) | 65 | 78 | Texas Tech (20) | Final | W | 13 |
| 21 | 2022-01-24 | Texas Tech (20) | 91 | 94 | Kansas (19) | Final/2OT | L | -3 |
| 22 | 2022-01-29 | Mississippi State (100) | 50 | 76 | Texas Tech (20) | Final | W | 26 |
| 23 | 2022-02-01 | Texas (25) | 64 | 77 | Texas Tech (16) | Final | W | 13 |
| 24 | 2022-02-05 | Texas Tech (20) | 60 | 53 | West Virginia (50) | Final | W | 7 |
| 25 | 2022-02-09 | Texas Tech (20) | 55 | 70 | Oklahoma (47) | Final | L | -15 |
| 26 | 2022-02-12 | TCU (32) | 69 | 82 | Texas Tech (20) | Final | W | 13 |
| 27 | 2022-02-16 | Baylor (4) | 73 | 83 | Texas Tech (12) | Final | W | 10 |
| 28 | 2022-02-19 | Texas Tech (12) | 61 | 55 | Texas (19) | Final | W | 6 |
| 29 | 2022-02-22 | Oklahoma (54) | 42 | 66 | Texas Tech (8) | Final | W | 24 |
| 30 | 2022-02-26 | Texas Tech (8) | 66 | 69 | TCU (42) | Final | L | -3 |
| 31 | 2022-02-28 | Kansas State (70) | 68 | 73 | Texas Tech (12) | Final | W | 5 |
| 32 | 2022-03-05 | Texas Tech (12) | 51 | 52 | Oklahoma State (71) | Final | L | -1 |
| 33 | 2022-03-10 | Iowa State (35) | 41 | 72 | Texas Tech (14) | Final | W | 31 |
| 34 | 2022-03-11 | Oklahoma (47) | 55 | 56 | Texas Tech (14) | Final | W | 1 |
| 35 | 2022-03-12 | Texas Tech (14) | 65 | 74 | Kansas (5) | Final | L | -9 |
| 36 | 2022-03-18 | Montana State (113) | 62 | 97 | Texas Tech (12) | Final | W | 35 |
| 37 | 2022-03-20 | Notre Dame (57) | 53 | 59 | Texas Tech (12) | Final | W | 6 |
| 38 | 2022-03-24 | Texas Tech (12) | 73 | 78 | Duke (13) | Final | L | -5 |