Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Central Michigan (298) | 68 | 78 | Missouri (34) | Final | W | 10 |
| 2 | 2021-11-15 | UMKC (288) | 80 | 66 | Missouri (128) | Final | L | -14 |
| 3 | 2021-11-18 | Northern Illinois (167) | 37 | 54 | Missouri (128) | Final | W | 17 |
| 4 | 2021-11-21 | Missouri (105) | 80 | 75 | SMU (141) | Final (OT) | W | 5 |
| 5 | 2021-11-22 | Florida State (64) | 81 | 58 | Missouri (51) | Final | L | -23 |
| 6 | 2021-11-26 | Wichita State (76) | 61 | 55 | Missouri (51) | Final | L | -6 |
| 7 | 2021-11-29 | Paul Quinn | 59 | 91 | Missouri (186) | Final | W | 32 |
| 8 | 2021-12-02 | Missouri (186) | 45 | 66 | Liberty (159) | Final | L | -21 |
| 9 | 2021-12-07 | Eastern Illinois (314) | 44 | 72 | Missouri (51) | Final | W | 28 |
| 10 | 2021-12-11 | Missouri (51) | 65 | 102 | Kansas (19) | Final | L | -37 |
| 11 | 2021-12-18 | Utah (130) | 75 | 83 | Missouri (51) | Final | W | 8 |
| 12 | 2021-12-22 | Missouri (51) | 63 | 88 | Illinois (9) | Final | L | -25 |
| 13 | 2021-12-29 | Missouri (51) | 56 | 83 | Kentucky (26) | Final | L | -27 |
| 14 | 2022-01-05 | Mississippi State (100) | 0 | 0 | Missouri (51) | Postponed | - | - |
| 15 | 2022-01-08 | Alabama (15) | 86 | 92 | Missouri (51) | Final | W | 6 |
| 16 | 2022-01-12 | Missouri (155) | 43 | 87 | Arkansas (71) | Final | L | -44 |
| 17 | 2022-01-15 | Texas A&M (39) | 67 | 64 | Missouri (51) | Final | L | -3 |
| 18 | 2022-01-18 | Missouri (51) | 78 | 53 | Ole Miss (79) | Final | W | 25 |
| 19 | 2022-01-22 | Missouri (51) | 76 | 86 | Alabama (15) | Final | L | -10 |
| 20 | 2022-01-25 | Auburn (1) | 55 | 54 | Missouri (145) | Final | L | -1 |
| 21 | 2022-01-29 | Missouri (51) | 50 | 67 | Iowa State (7) | Final | L | -17 |
| 22 | 2022-02-02 | Florida (50) | 66 | 65 | Missouri (145) | Final | L | -1 |
| 23 | 2022-02-05 | Missouri (51) | 70 | 66 | Texas A&M (39) | Final | W | 4 |
| 24 | 2022-02-08 | Missouri (128) | 62 | 70 | Vanderbilt (85) | Final | L | -8 |
| 25 | 2022-02-12 | Ole Miss (79) | 68 | 74 | Missouri (51) | Final | W | 6 |
| 26 | 2022-02-15 | Arkansas (28) | 76 | 57 | Missouri (127) | Final | L | -19 |
| 27 | 2022-02-18 | Missouri (127) | 49 | 68 | Mississippi State (60) | Final | L | -19 |
| 28 | 2022-02-20 | Mississippi State (53) | 58 | 56 | Missouri (133) | Final | L | -2 |
| 29 | 2022-02-22 | Tennessee (14) | 80 | 61 | Missouri (133) | Final | L | -19 |
| 30 | 2022-02-26 | Missouri (133) | 55 | 75 | LSU (19) | Final | L | -20 |
| 31 | 2022-03-01 | Missouri (141) | 69 | 73 | South Carolina (65) | Final | L | -4 |
| 32 | 2022-03-05 | Georgia (215) | 69 | 79 | Missouri (141) | Final | W | 10 |
| 33 | 2022-03-09 | Ole Miss (107) | 60 | 72 | Missouri (140) | Final | W | 12 |
| 34 | 2022-03-10 | Missouri (140) | 68 | 76 | LSU (22) | Final | L | -8 |