Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-23 | Louisiana Tech (70) | 99 | 109 | SMU (54) | Final | L | -10 |
| 2 | 2021-11-04 | Mississippi College | 50 | 86 | Louisiana Tech (70) | Final | W | 36 |
| 3 | 2021-11-09 | Louisiana Tech (70) | 64 | 93 | Alabama (6) | Final | L | -29 |
| 4 | 2021-11-12 | Jackson State (329) | 68 | 70 | Louisiana Tech (185) | Final | W | 2 |
| 5 | 2021-11-15 | Jarvis Christian | 61 | 91 | Louisiana Tech (194) | Final | W | 30 |
| 6 | 2021-11-19 | Louisiana Tech (185) | 83 | 64 | Northwestern State (315) | Final | W | 19 |
| 7 | 2021-11-24 | Louisiana-Monroe (358) | 74 | 96 | Louisiana Tech (185) | Final | W | 22 |
| 8 | 2021-11-27 | Louisiana Tech (158) | 81 | 90 | North Carolina State (96) | Final | L | -9 |
| 9 | 2021-12-01 | Texas Southern (317) | 60 | 87 | Louisiana Tech (185) | Final | W | 27 |
| 10 | 2021-12-04 | Louisiana Tech (185) | 78 | 75 | Santa Clara (42) | Final | W | 3 |
| 11 | 2021-12-11 | Louisiana (290) | 69 | 78 | Louisiana Tech (185) | Final | W | 9 |
| 12 | 2021-12-14 | LSU Shreveport | 70 | 84 | Louisiana Tech (185) | Final | W | 14 |
| 13 | 2021-12-18 | LSU (77) | 66 | 57 | Louisiana Tech (185) | Final | L | -9 |
| 14 | 2021-12-22 | Crowley's Ridge | 56 | 99 | Louisiana Tech (185) | Final | W | 43 |
| 15 | 2021-12-30 | Marshall (155) | 56 | 79 | Louisiana Tech (185) | Final | W | 23 |
| 16 | 2022-01-01 | Western Kentucky (154) | 73 | 74 | Louisiana Tech (185) | Final | W | 1 |
| 17 | 2022-01-06 | Louisiana Tech (185) | 64 | 52 | UTEP (274) | Final | W | 12 |
| 18 | 2022-01-08 | Louisiana Tech (185) | 79 | 63 | UTSA (344) | Final | W | 16 |
| 19 | 2022-01-13 | Southern Miss (201) | 57 | 80 | Louisiana Tech (185) | Final | W | 23 |
| 20 | 2022-01-16 | Louisiana Tech (75) | 76 | 62 | Southern Miss (303) | Final | W | 14 |
| 21 | 2022-01-22 | UAB (115) | 83 | 76 | Louisiana Tech (185) | Final | L | -7 |
| 22 | 2022-01-27 | Rice (228) | 63 | 80 | Louisiana Tech (185) | Final | W | 17 |
| 23 | 2022-01-29 | North Texas (125) | 63 | 62 | Louisiana Tech (185) | Final | L | -1 |
| 24 | 2022-02-03 | Louisiana Tech (185) | 73 | 83 | Florida Atlantic (128) | Final | L | -10 |
| 25 | 2022-02-05 | Louisiana Tech (185) | 86 | 82 | Florida International (214) | Final | W | 4 |
| 26 | 2022-02-10 | Louisiana Tech (185) | 82 | 77 | Charlotte (173) | Final | W | 5 |
| 27 | 2022-02-17 | UTEP (274) | 63 | 60 | Louisiana Tech (185) | Final | L | -3 |
| 28 | 2022-02-19 | UTSA (331) | 71 | 95 | Louisiana Tech (97) | Final | W | 24 |
| 29 | 2022-02-24 | Louisiana Tech (107) | 83 | 79 | Rice (184) | Final | W | 4 |
| 30 | 2022-02-26 | Louisiana Tech (107) | 49 | 56 | North Texas (40) | Final | L | -7 |
| 31 | 2022-03-02 | Old Dominion (207) | 54 | 67 | Louisiana Tech (108) | Final | W | 13 |
| 32 | 2022-03-05 | Louisiana Tech (108) | 74 | 87 | UAB (63) | Final | L | -13 |
| 33 | 2022-03-09 | Marshall (248) | 67 | 77 | Louisiana Tech (108) | Final | W | 10 |
| 34 | 2022-03-10 | Louisiana Tech (108) | 59 | 57 | Western Kentucky (121) | Final | W | 2 |
| 35 | 2022-03-11 | Louisiana Tech (108) | 42 | 36 | North Texas (49) | Final | W | 6 |
| 36 | 2022-03-12 | Louisiana Tech (108) | 73 | 82 | UAB (60) | Final | L | -9 |