Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Spring Hill | 41 | 102 | South Alabama (178) | Final | W | 61 |
| 2 | 2021-11-13 | South Alabama (178) | 58 | 64 | Wichita State (47) | Final | L | -6 |
| 3 | 2021-11-16 | South Alabama (186) | 68 | 73 | Alabama (8) | Final | L | -5 |
| 4 | 2021-11-20 | Mobile | 45 | 78 | South Alabama (177) | Final | W | 33 |
| 5 | 2021-11-22 | William Carey | 53 | 96 | South Alabama (177) | Final | W | 43 |
| 6 | 2021-11-25 | South Alabama (177) | 68 | 67 | San Diego (246) | Final | W | 1 |
| 7 | 2021-11-26 | Hawaii (109) | 69 | 72 | South Alabama (177) | Final | W | 3 |
| 8 | 2021-11-29 | Texas A&M-Commerce | 66 | 69 | South Alabama (115) | Final | W | 3 |
| 9 | 2021-12-01 | Southern Miss (201) | 55 | 85 | South Alabama (177) | Final | W | 30 |
| 10 | 2021-12-04 | South Alabama (177) | 74 | 64 | Jacksonville State (227) | Final | W | 10 |
| 11 | 2021-12-14 | Tarleton State (234) | 62 | 69 | South Alabama (177) | Final | W | 7 |
| 12 | 2021-12-17 | South Alabama (177) | 52 | 65 | Tarleton State (234) | Final | L | -13 |
| 13 | 2021-12-21 | SIU-Edwardsville (248) | 69 | 84 | South Alabama (177) | Final | W | 15 |
| 14 | 2021-12-30 | South Alabama (177) | 87 | 89 | Texas-Arlington (162) | Final/OT | L | -2 |
| 15 | 2022-01-01 | South Alabama (177) | 0 | 0 | Texas State (199) | Canceled | - | - |
| 16 | 2022-01-06 | Appalachian State (159) | 72 | 64 | South Alabama (177) | Final | L | -8 |
| 17 | 2022-01-08 | Coastal Carolina (188) | 0 | 0 | South Alabama (177) | Canceled | - | - |
| 18 | 2022-01-13 | Georgia State (299) | 65 | 74 | South Alabama (177) | Final | W | 9 |
| 19 | 2022-01-15 | Georgia Southern (216) | 67 | 73 | South Alabama (177) | Final | W | 6 |
| 20 | 2022-01-20 | South Alabama (177) | 77 | 70 | Louisiana (290) | Final | W | 7 |
| 21 | 2022-01-22 | South Alabama (177) | 68 | 56 | Louisiana-Monroe (358) | Final | W | 12 |
| 22 | 2022-01-27 | Troy (127) | 63 | 82 | South Alabama (177) | Final | W | 19 |
| 23 | 2022-01-29 | South Alabama (177) | 68 | 77 | Troy (127) | Final | L | -9 |
| 24 | 2022-02-03 | South Alabama (177) | 57 | 58 | Georgia Southern (216) | Final | L | -1 |
| 25 | 2022-02-05 | South Alabama (177) | 62 | 69 | Georgia State (299) | Final | L | -7 |
| 26 | 2022-02-10 | Little Rock (321) | 46 | 77 | South Alabama (177) | Final | W | 31 |
| 27 | 2022-02-12 | Arkansas State (147) | 51 | 70 | South Alabama (177) | Final | W | 19 |
| 28 | 2022-02-17 | South Alabama (177) | 71 | 68 | Coastal Carolina (188) | Final | W | 3 |
| 29 | 2022-02-19 | South Alabama (136) | 51 | 69 | Appalachian State (141) | Final | L | -18 |
| 30 | 2022-02-23 | Texas State (115) | 55 | 52 | South Alabama (136) | Final | L | -3 |
| 31 | 2022-02-25 | Texas-Arlington (231) | 52 | 62 | South Alabama (136) | Final | W | 10 |
| 32 | 2022-03-03 | Little Rock (296) | 75 | 71 | South Alabama (139) | Final | L | -4 |
| 33 | 2022-03-16 | Southeastern Louisiana (318) | 68 | 70 | South Alabama (177) | Final | W | 2 |
| 34 | 2022-03-21 | South Carolina Upstate (251) | 79 | 83 | South Alabama (156) | Final | W | 4 |
| 35 | 2022-03-28 | Coastal Carolina (172) | 69 | 68 | South Alabama (156) | Final | L | -1 |