Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Benedict | 76 | 101 | South Carolina (151) | Final | W | 25 |
| 2 | 2021-11-09 | South Carolina Upstate (335) | 60 | 78 | South Carolina (151) | Final | W | 18 |
| 3 | 2021-11-12 | Princeton (271) | 66 | 62 | South Carolina (110) | Final | L | -4 |
| 4 | 2021-11-14 | Western Kentucky (154) | 64 | 75 | South Carolina (110) | Final | W | 11 |
| 5 | 2021-11-18 | UAB (77) | 63 | 66 | South Carolina (120) | Final | W | 3 |
| 6 | 2021-11-23 | Wofford (87) | 74 | 85 | South Carolina (72) | Final | W | 11 |
| 7 | 2021-11-28 | Rider (290) | 58 | 65 | South Carolina (52) | Final | W | 7 |
| 8 | 2021-12-01 | South Carolina (110) | 56 | 80 | Coastal Carolina (188) | Final | L | -24 |
| 9 | 2021-12-05 | Georgetown (236) | 67 | 80 | South Carolina (52) | Final | W | 13 |
| 10 | 2021-12-12 | Florida State (64) | 65 | 66 | South Carolina (110) | Final | W | 1 |
| 11 | 2021-12-14 | Allen | 51 | 110 | South Carolina (110) | Final | W | 59 |
| 12 | 2021-12-18 | South Carolina (110) | 56 | 70 | Clemson (36) | Final | L | -14 |
| 13 | 2021-12-22 | Army (339) | 75 | 105 | South Carolina (110) | Final | W | 30 |
| 14 | 2021-12-29 | South Carolina State (355) | 0 | 0 | South Carolina (110) | Cancelled | - | - |
| 15 | 2022-01-04 | Auburn (37) | 81 | 66 | South Carolina (110) | Final | L | -15 |
| 16 | 2022-01-08 | South Carolina (110) | 72 | 70 | Vanderbilt (17) | Final | W | 2 |
| 17 | 2022-01-11 | South Carolina (110) | 46 | 66 | Tennessee (18) | Final | L | -20 |
| 18 | 2022-01-15 | Florida (6) | 71 | 63 | South Carolina (110) | Final | L | -8 |
| 19 | 2022-01-18 | South Carolina (110) | 59 | 75 | Arkansas (16) | Final | L | -16 |
| 20 | 2022-01-22 | Georgia (35) | 66 | 83 | South Carolina (110) | Final | W | 17 |
| 21 | 2022-01-26 | Vanderbilt (85) | 61 | 70 | South Carolina (80) | Final | W | 9 |
| 22 | 2022-01-29 | South Carolina (110) | 74 | 63 | Texas A&M (39) | Final | W | 11 |
| 23 | 2022-02-01 | South Carolina (71) | 64 | 78 | Mississippi State (52) | Final | L | -14 |
| 24 | 2022-02-05 | Tennessee (18) | 81 | 57 | South Carolina (110) | Final | L | -24 |
| 25 | 2022-02-08 | Kentucky (7) | 86 | 76 | South Carolina (86) | Final | L | -10 |
| 26 | 2022-02-12 | South Carolina (110) | 80 | 68 | Georgia (35) | Final | W | 12 |
| 27 | 2022-02-15 | South Carolina (87) | 77 | 74 | Ole Miss (99) | Final (OT) | W | 3 |
| 28 | 2022-02-19 | LSU (17) | 75 | 77 | South Carolina (87) | Final | W | 2 |
| 29 | 2022-02-23 | Mississippi State (53) | 56 | 66 | South Carolina (71) | Final | W | 10 |
| 30 | 2022-02-26 | South Carolina (71) | 71 | 90 | Alabama (22) | Final | L | -19 |
| 31 | 2022-03-01 | Missouri (141) | 69 | 73 | South Carolina (65) | Final | W | 4 |
| 32 | 2022-03-05 | South Carolina (65) | 71 | 82 | Auburn (4) | Final | L | -11 |
| 33 | 2022-03-10 | Mississippi State (64) | 73 | 51 | South Carolina (66) | Final | L | -22 |