Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-03 | Ferrum | 56 | 98 | Davidson (74) | Final | W | 42 |
| 2 | 2021-11-09 | Delaware (240) | 71 | 93 | Davidson (74) | Final | W | 22 |
| 3 | 2021-11-13 | Davidson (74) | 60 | 65 | San Francisco (124) | Final | L | -5 |
| 4 | 2021-11-18 | Davidson (124) | 64 | 75 | New Mexico State (41) | Final | L | -11 |
| 5 | 2021-11-19 | Davidson (111) | 72 | 60 | Penn (131) | Final | W | 12 |
| 6 | 2021-11-21 | Davidson (80) | 76 | 67 | East Carolina (132) | Final | W | 9 |
| 7 | 2021-11-27 | Robert Morris (326) | 70 | 88 | Davidson (80) | Final | W | 18 |
| 8 | 2021-11-30 | Davidson (80) | 75 | 58 | Charlotte (139) | Final | W | 17 |
| 9 | 2021-12-04 | William & Mary (141) | 46 | 70 | Davidson (111) | Final | W | 24 |
| 10 | 2021-12-12 | Davidson (111) | 79 | 69 | Northeastern (300) | Final | W | 10 |
| 11 | 2021-12-18 | Radford (255) | 54 | 74 | Davidson (111) | Final | W | 20 |
| 12 | 2021-12-21 | Davidson (111) | 79 | 78 | Alabama (15) | Final | W | 1 |
| 13 | 2021-12-22 | Johnson & Wales (NC) | 64 | 106 | Davidson (111) | Final | W | 42 |
| 14 | 2021-12-22 | Loyola-Chicago | 0 | 0 | Davidson | Cancelled | - | - |
| 15 | 2021-12-30 | Duquesne (121) | 0 | 0 | Davidson (111) | Postponed | - | - |
| 16 | 2022-01-02 | Davidson (111) | 0 | 0 | Virginia Commonwealth (38) | Postponed | - | - |
| 17 | 2022-01-05 | Davidson (111) | 88 | 73 | Saint Joseph's (99) | Final | W | 15 |
| 18 | 2022-01-08 | Rhode Island (145) | 68 | 72 | Davidson (111) | Final | W | 4 |
| 19 | 2022-01-11 | Massachusetts (182) | 67 | 77 | Davidson (111) | Final | W | 10 |
| 20 | 2022-01-14 | Davidson (34) | 87 | 84 | Richmond (102) | Final | W | 3 |
| 21 | 2022-01-18 | Davidson (111) | 63 | 61 | Virginia Commonwealth (38) | Final | W | 2 |
| 22 | 2022-01-22 | Davidson (111) | 69 | 66 | Fordham (183) | Final | W | 3 |
| 23 | 2022-01-26 | Virginia Commonwealth (66) | 70 | 68 | Davidson (27) | Final | L | -2 |
| 24 | 2022-01-29 | La Salle (237) | 69 | 77 | Davidson (111) | Final | W | 8 |
| 25 | 2022-02-01 | Davidson (35) | 81 | 76 | St. Bonaventure (72) | Final | W | 5 |
| 26 | 2022-02-05 | Davidson (111) | 78 | 73 | George Washington (104) | Final | W | 5 |
| 27 | 2022-02-09 | Saint Joseph's (99) | 67 | 73 | Davidson (111) | Final/OT | W | 6 |
| 28 | 2022-02-12 | Davidson (111) | 65 | 72 | Rhode Island (145) | Final | L | -7 |
| 29 | 2022-02-14 | Duquesne (121) | 61 | 72 | Davidson (111) | Final | W | 11 |
| 30 | 2022-02-19 | Saint Louis (53) | 58 | 79 | Davidson (38) | Final | W | 21 |
| 31 | 2022-02-23 | Davidson (35) | 74 | 50 | Duquesne (268) | Final | W | 24 |
| 32 | 2022-02-26 | Fordham (183) | 45 | 66 | Davidson (35) | Final | W | 21 |
| 33 | 2022-03-02 | George Mason (119) | 62 | 73 | Davidson (33) | Final | W | 11 |
| 34 | 2022-03-05 | Davidson (33) | 76 | 82 | Dayton (67) | Final | L | -6 |
| 35 | 2022-03-11 | Fordham (179) | 56 | 74 | Davidson (36) | Final | W | 18 |
| 36 | 2022-03-12 | Saint Louis (56) | 69 | 84 | Davidson (36) | Final | W | 15 |
| 37 | 2022-03-13 | Richmond (77) | 64 | 62 | Davidson (37) | Final | L | -2 |
| 38 | 2022-03-18 | Davidson (37) | 73 | 74 | Michigan State (30) | Final | L | -1 |