Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-06 | Montana Tech | 51 | 78 | Houston (5) | Final | W | 27 |
| 2 | 2021-11-09 | Hofstra (163) | 75 | 83 | Houston (5) | Final (OT) | W | 8 |
| 3 | 2021-11-12 | Rice (228) | 46 | 79 | Houston (5) | Final | W | 33 |
| 4 | 2021-11-16 | Virginia (193) | 47 | 67 | Houston (6) | Final | W | 20 |
| 5 | 2021-11-22 | Butler (80) | 52 | 70 | Houston (5) | Final | W | 18 |
| 6 | 2021-11-23 | Wisconsin (111) | 65 | 63 | Houston (20) | Final | L | -2 |
| 7 | 2021-11-24 | Houston (5) | 78 | 49 | Oregon (102) | Final | W | 29 |
| 8 | 2021-11-30 | Northwestern State (347) | 58 | 99 | Houston (19) | Final | W | 41 |
| 9 | 2021-12-03 | Bryant (349) | 44 | 111 | Houston (5) | Final | W | 67 |
| 10 | 2021-12-06 | Alcorn State (305) | 45 | 77 | Houston (10) | Final | W | 32 |
| 11 | 2021-12-11 | Houston (5) | 82 | 83 | Alabama (15) | Final | L | -1 |
| 12 | 2021-12-14 | Louisiana (290) | 56 | 71 | Houston (5) | Final | W | 15 |
| 13 | 2021-12-18 | Oklahoma State (57) | 61 | 72 | Houston (5) | Final | W | 11 |
| 14 | 2021-12-22 | Texas State (199) | 47 | 80 | Houston (5) | Final | W | 33 |
| 15 | 2021-12-28 | Cincinnati (54) | 0 | 0 | Houston (5) | Postponed | - | - |
| 16 | 2022-01-02 | Houston (5) | 66 | 61 | Temple (169) | Final | W | 5 |
| 17 | 2022-01-05 | Houston (5) | 83 | 66 | South Florida (52) | Final | W | 17 |
| 18 | 2022-01-08 | Wichita State (76) | 66 | 76 | Houston (5) | Final | W | 10 |
| 19 | 2022-01-15 | Houston (5) | 66 | 64 | Tulsa (55) | Final | W | 2 |
| 20 | 2022-01-18 | South Florida (52) | 55 | 74 | Houston (5) | Final | W | 19 |
| 21 | 2022-01-22 | East Carolina (252) | 36 | 79 | Houston (5) | Final | W | 43 |
| 22 | 2022-01-29 | Houston (5) | 63 | 49 | Central Florida (43) | Final | W | 14 |
| 23 | 2022-02-02 | Tulane (125) | 62 | 73 | Houston (7) | Final | W | 11 |
| 24 | 2022-02-06 | Houston (5) | 80 | 58 | Cincinnati (54) | Final | W | 22 |
| 25 | 2022-02-06 | Houston (5) | 83 | 59 | Cincinnati (80) | Final | W | 24 |
| 26 | 2022-02-09 | Houston (5) | 83 | 85 | SMU (45) | Final | L | -2 |
| 27 | 2022-02-12 | Memphis (136) | 69 | 59 | Houston (5) | Final | L | -10 |
| 28 | 2022-02-17 | Central Florida (43) | 52 | 70 | Houston (5) | Final | W | 18 |
| 29 | 2022-02-20 | Houston (13) | 76 | 74 | Wichita State (86) | Final | W | 2 |
| 30 | 2022-02-23 | Houston (13) | 81 | 67 | Tulane (114) | Final | W | 14 |
| 31 | 2022-02-27 | SMU (48) | 61 | 75 | Houston (10) | Final | W | 14 |
| 32 | 2022-03-03 | Temple (97) | 46 | 84 | Houston (10) | Final | W | 38 |
| 33 | 2022-03-06 | Houston (12) | 61 | 75 | Memphis (43) | Final | L | -14 |
| 34 | 2022-03-11 | Cincinnati (110) | 56 | 69 | Houston (12) | Final | W | 13 |
| 35 | 2022-03-12 | Tulane (113) | 66 | 86 | Houston (12) | Final | W | 20 |
| 36 | 2022-03-13 | Memphis (40) | 53 | 71 | Houston (9) | Final | W | 18 |
| 37 | 2022-03-18 | UAB (53) | 68 | 82 | Houston (9) | Final | W | 14 |
| 38 | 2022-03-20 | Houston (9) | 68 | 53 | Illinois (19) | Final | W | 15 |
| 39 | 2022-03-24 | Houston (9) | 72 | 60 | Arizona (1) | Final | W | 12 |
| 40 | 2022-03-26 | Houston (9) | 44 | 50 | Villanova (7) | Final | L | -6 |