Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | ERAU (Daytona Beach) | 57 | 80 | Florida (39) | Final | W | 23 |
| 2 | 2021-11-09 | Elon (206) | 61 | 74 | Florida (39) | Final | W | 13 |
| 3 | 2021-11-14 | Florida State (64) | 55 | 71 | Florida (6) | Final | W | 16 |
| 4 | 2021-11-18 | Milwaukee (176) | 45 | 81 | Florida (18) | Final | W | 36 |
| 5 | 2021-11-22 | Florida (6) | 80 | 60 | California (65) | Final | W | 20 |
| 6 | 2021-11-24 | Florida (6) | 71 | 68 | Ohio State (34) | Final | W | 3 |
| 7 | 2021-11-28 | Troy (194) | 45 | 84 | Florida (6) | Final | W | 39 |
| 8 | 2021-12-01 | Florida (6) | 67 | 74 | Oklahoma (47) | Final | L | -7 |
| 9 | 2021-12-06 | Texas Southern (327) | 69 | 54 | Florida (24) | Final | L | -15 |
| 10 | 2021-12-08 | North Florida (319) | 55 | 85 | Florida (24) | Final | W | 30 |
| 11 | 2021-12-12 | Florida (6) | 68 | 70 | Maryland (114) | Final | L | -2 |
| 12 | 2021-12-18 | South Florida (52) | 55 | 66 | Florida (6) | Final | W | 11 |
| 13 | 2021-12-22 | Stony Brook (213) | 62 | 87 | Florida (6) | Final | W | 25 |
| 14 | 2021-12-29 | Florida (6) | 0 | 0 | Ole Miss (79) | Postponed | - | - |
| 15 | 2022-01-05 | Alabama (15) | 83 | 70 | Florida (6) | Final | L | -13 |
| 16 | 2022-01-08 | Florida (6) | 73 | 85 | Auburn (37) | Final | L | -12 |
| 17 | 2022-01-12 | LSU (2) | 64 | 58 | Florida (57) | Final | L | -6 |
| 18 | 2022-01-15 | Florida (6) | 71 | 63 | South Carolina (110) | Final | W | 8 |
| 19 | 2022-01-19 | Mississippi State (100) | 72 | 80 | Florida (6) | Final | W | 8 |
| 20 | 2022-01-22 | Vanderbilt (17) | 42 | 61 | Florida (6) | Final | W | 19 |
| 21 | 2022-01-24 | Florida (6) | 54 | 70 | Ole Miss (79) | Final | L | -16 |
| 22 | 2022-01-26 | Florida (43) | 71 | 78 | Tennessee (17) | Final | L | -7 |
| 23 | 2022-01-29 | Oklahoma State (57) | 72 | 81 | Florida (6) | Final | W | 9 |
| 24 | 2022-02-02 | Florida (50) | 66 | 65 | Missouri (145) | Final | W | 1 |
| 25 | 2022-02-05 | Ole Miss (79) | 57 | 62 | Florida (6) | Final/OT | W | 5 |
| 26 | 2022-02-09 | Georgia (35) | 63 | 72 | Florida (6) | Final | W | 9 |
| 27 | 2022-02-12 | Florida (6) | 57 | 78 | Kentucky (26) | Final | L | -21 |
| 28 | 2022-02-15 | Florida (47) | 55 | 56 | Texas A&M (70) | Final | L | -1 |
| 29 | 2022-02-19 | Auburn (3) | 62 | 63 | Florida (47) | Final | W | 1 |
| 30 | 2022-02-22 | Arkansas (20) | 82 | 74 | Florida (49) | Final | L | -8 |
| 31 | 2022-02-26 | Florida (49) | 84 | 72 | Georgia (210) | Final | W | 12 |
| 32 | 2022-03-01 | Florida (51) | 82 | 78 | Vanderbilt (79) | Final | W | 4 |
| 33 | 2022-03-05 | Kentucky (6) | 71 | 63 | Florida (51) | Final | L | -8 |
| 34 | 2022-03-10 | Florida (50) | 80 | 83 | Texas A&M (53) | Final | L | -3 |
| 35 | 2022-03-16 | Iona (220) | 74 | 79 | Florida (6) | Final | W | 5 |
| 36 | 2022-03-20 | Florida (54) | 56 | 72 | Xavier (42) | Final | L | -16 |