Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-23 | LSU (26) | 74 | 62 | Nicholls State (159) | Final | W | 12 |
| 2 | 2021-11-09 | Louisiana-Monroe (291) | 39 | 101 | LSU (26) | Final | W | 62 |
| 3 | 2021-11-12 | Texas State (199) | 59 | 84 | LSU (77) | Final | W | 25 |
| 4 | 2021-11-15 | Liberty (127) | 58 | 74 | LSU (15) | Final | W | 16 |
| 5 | 2021-11-18 | McNeese State (344) | 46 | 85 | LSU (15) | Final | W | 39 |
| 6 | 2021-11-22 | Belmont (68) | 53 | 83 | LSU (77) | Final | W | 30 |
| 7 | 2021-11-26 | Penn State (129) | 63 | 68 | LSU (77) | Final/OT | W | 5 |
| 8 | 2021-11-27 | LSU (9) | 75 | 61 | Wake Forest (50) | Final | W | 14 |
| 9 | 2021-12-01 | Ohio (218) | 51 | 66 | LSU (77) | Final | W | 15 |
| 10 | 2021-12-11 | LSU (77) | 69 | 53 | Georgia Tech (158) | Final | W | 16 |
| 11 | 2021-12-14 | Northwestern State (315) | 49 | 89 | LSU (77) | Final | W | 40 |
| 12 | 2021-12-18 | LSU (77) | 66 | 57 | Louisiana Tech (185) | Final | W | 9 |
| 13 | 2021-12-22 | Lipscomb (190) | 60 | 95 | LSU (77) | Final | W | 35 |
| 14 | 2021-12-29 | LSU (77) | 55 | 70 | Auburn (37) | Final | L | -15 |
| 15 | 2022-01-04 | Kentucky (26) | 60 | 65 | LSU (77) | Final | W | 5 |
| 16 | 2022-01-08 | Tennessee (18) | 67 | 79 | LSU (77) | Final | W | 12 |
| 17 | 2022-01-12 | LSU (2) | 64 | 58 | Florida (57) | Final | W | 6 |
| 18 | 2022-01-15 | Arkansas (16) | 65 | 58 | LSU (77) | Final | L | -7 |
| 19 | 2022-01-19 | LSU (77) | 67 | 70 | Alabama (15) | Final | L | -3 |
| 20 | 2022-01-22 | LSU (77) | 50 | 64 | Tennessee (18) | Final | L | -14 |
| 21 | 2022-01-26 | Texas A&M (45) | 64 | 70 | LSU (8) | Final | W | 6 |
| 22 | 2022-01-29 | LSU (77) | 68 | 77 | TCU (32) | Final | L | -9 |
| 23 | 2022-02-01 | Ole Miss (104) | 76 | 72 | LSU (12) | Final | L | -4 |
| 24 | 2022-02-05 | LSU (77) | 66 | 75 | Vanderbilt (17) | Final | L | -9 |
| 25 | 2022-02-08 | LSU (18) | 76 | 68 | Texas A&M (65) | Final | W | 8 |
| 26 | 2022-02-12 | Mississippi State (100) | 65 | 69 | LSU (77) | Final | W | 4 |
| 27 | 2022-02-16 | Georgia (205) | 65 | 84 | LSU (17) | Final | W | 19 |
| 28 | 2022-02-19 | LSU (17) | 75 | 77 | South Carolina (87) | Final | L | -2 |
| 29 | 2022-02-23 | LSU (19) | 66 | 71 | Kentucky (7) | Final | L | -5 |
| 30 | 2022-02-26 | Missouri (133) | 55 | 75 | LSU (19) | Final | W | 20 |
| 31 | 2022-03-02 | LSU (25) | 76 | 77 | Arkansas (17) | Final | L | -1 |
| 32 | 2022-03-05 | Alabama (21) | 77 | 80 | LSU (25) | Final | W | 3 |
| 33 | 2022-03-10 | Missouri (140) | 68 | 76 | LSU (22) | Final | W | 8 |
| 34 | 2022-03-11 | LSU (22) | 67 | 79 | Arkansas (16) | Final | L | -12 |
| 35 | 2022-03-18 | Iowa State (39) | 59 | 54 | LSU (23) | Final | L | -5 |