Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Lake Superior State | 81 | 91 | Oakland (250) | Final | W | 10 |
| 2 | 2021-11-09 | Oakland (250) | 53 | 60 | West Virginia (17) | Final | L | -7 |
| 3 | 2021-11-12 | Oakland (172) | 56 | 55 | Oklahoma State (57) | Final | W | 1 |
| 4 | 2021-11-17 | Toledo (135) | 59 | 80 | Oakland (172) | Final | W | 21 |
| 5 | 2021-11-19 | Oakland (172) | 59 | 86 | Alabama (15) | Final | L | -27 |
| 6 | 2021-11-22 | Oakland (172) | 63 | 61 | Vermont (225) | Final | W | 2 |
| 7 | 2021-11-23 | Oakland (98) | 76 | 73 | Rice (106) | Final | W | 3 |
| 8 | 2021-11-24 | Delaware (287) | 73 | 81 | Oakland (172) | Final | W | 8 |
| 9 | 2021-12-02 | Oakland (47) | 81 | 77 | Illinois-Chicago (275) | Final | W | 4 |
| 10 | 2021-12-04 | Oakland (172) | 78 | 45 | IU-Indy (338) | Final | W | 33 |
| 11 | 2021-12-04 | Oakland (47) | 78 | 45 | IUPUI (355) | Final | W | 33 |
| 12 | 2021-12-07 | Oakland (172) | 72 | 73 | Bowling Green (168) | Final | L | -1 |
| 13 | 2021-12-21 | Michigan State (10) | 90 | 78 | Oakland (172) | Final | L | -12 |
| 14 | 2021-12-30 | Robert Morris (148) | 61 | 79 | Oakland (172) | Final | W | 18 |
| 15 | 2022-01-01 | Youngstown State (231) | 72 | 87 | Oakland (172) | Final | W | 15 |
| 16 | 2022-01-05 | Oakland (172) | 0 | 0 | Detroit (212) | Canceled | - | - |
| 17 | 2022-01-07 | Ohio Christian | 40 | 108 | Oakland (172) | Final | W | 68 |
| 18 | 2022-01-09 | Milwaukee (314) | 65 | 86 | Oakland (62) | Final | W | 21 |
| 19 | 2022-01-13 | Oakland (172) | 70 | 65 | Cleveland State (308) | Final | W | 5 |
| 20 | 2022-01-15 | Oakland (172) | 76 | 68 | Purdue Fort Wayne (222) | Final | W | 8 |
| 21 | 2022-01-20 | Oakland (172) | 78 | 88 | Milwaukee (261) | Final | L | -10 |
| 22 | 2022-01-22 | Oakland (172) | 68 | 61 | Green Bay (206) | Final | W | 7 |
| 23 | 2022-01-24 | Michigan-Dearborn | 61 | 104 | Oakland (172) | Final | W | 43 |
| 24 | 2022-01-24 | Michigan-Dearborn | 61 | 104 | Oakland (74) | Final | W | 43 |
| 25 | 2022-01-27 | IU-Indy (338) | 0 | 0 | Oakland (172) | Canceled | - | - |
| 26 | 2022-01-29 | Illinois-Chicago (139) | 74 | 81 | Oakland (172) | Final | W | 7 |
| 27 | 2022-02-03 | Oakland (172) | 0 | 0 | Northern Kentucky (195) | Postponed | - | - |
| 28 | 2022-02-04 | Oakland (81) | 78 | 87 | Northern Kentucky (246) | Final (OT) | L | -9 |
| 29 | 2022-02-05 | Oakland (172) | 64 | 75 | Wright State (124) | Final | L | -11 |
| 30 | 2022-02-09 | Oakland (172) | 71 | 78 | Youngstown State (231) | Final | L | -7 |
| 31 | 2022-02-11 | Oakland (172) | 71 | 68 | Robert Morris (148) | Final | W | 3 |
| 32 | 2022-02-13 | Detroit (267) | 59 | 75 | Oakland (117) | Final | W | 16 |
| 33 | 2022-02-18 | Wright State (221) | 78 | 74 | Oakland (117) | Final | L | -4 |
| 34 | 2022-02-20 | Northern Kentucky (223) | 71 | 66 | Oakland (143) | Final | L | -5 |
| 35 | 2022-02-24 | Purdue Fort Wayne (215) | 81 | 70 | Oakland (143) | Final | L | -11 |
| 36 | 2022-02-26 | Cleveland State (161) | 57 | 65 | Oakland (143) | Final | W | 8 |
| 37 | 2022-03-01 | IUPUI (357) | 58 | 70 | Oakland (148) | Final | W | 12 |
| 38 | 2022-03-03 | Oakland (148) | 63 | 75 | Wright State (211) | Final | L | -12 |