Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-24 | Louisiana (175) | 68 | 73 | Alabama (6) | Final | L | -5 |
| 2 | 2021-11-09 | West Florida | 47 | 81 | Louisiana (175) | Final | W | 34 |
| 3 | 2021-11-12 | Louisiana (290) | 66 | 45 | Southern Miss (201) | Final | W | 21 |
| 4 | 2021-11-17 | Xavier (LA) | 72 | 84 | Louisiana (290) | Final | W | 12 |
| 5 | 2021-11-21 | Louisiana (178) | 44 | 76 | Indiana (17) | Final | L | -32 |
| 6 | 2021-11-23 | Louisiana (178) | 79 | 93 | Marshall (167) | Final | L | -14 |
| 7 | 2021-11-27 | Jackson State (329) | 75 | 70 | Louisiana (178) | Final | L | -5 |
| 8 | 2021-12-03 | New Orleans (236) | 67 | 80 | Louisiana (290) | Final | W | 13 |
| 9 | 2021-12-08 | McNeese State (290) | 68 | 83 | Louisiana (246) | Final | W | 15 |
| 10 | 2021-12-11 | Louisiana (290) | 69 | 78 | Louisiana Tech (185) | Final | L | -9 |
| 11 | 2021-12-14 | Louisiana (290) | 56 | 71 | Houston (5) | Final | L | -15 |
| 12 | 2021-12-20 | Loyola-New Orleans | 0 | 0 | Louisiana (290) | Cancelled | - | - |
| 13 | 2021-12-20 | Loyola (LA) | 0 | 0 | Louisiana (246) | Cancelled | - | - |
| 14 | 2021-12-30 | Louisiana (290) | 71 | 55 | Appalachian State (159) | Final | W | 16 |
| 15 | 2022-01-01 | Louisiana (290) | 65 | 64 | Coastal Carolina (188) | Final | W | 1 |
| 16 | 2022-01-06 | Arkansas State (147) | 77 | 83 | Louisiana (290) | Final/OT | W | 6 |
| 17 | 2022-01-08 | Little Rock (321) | 0 | 0 | Louisiana (290) | Canceled | - | - |
| 18 | 2022-01-13 | Louisiana (290) | 73 | 83 | Texas-Arlington (162) | Final | L | -10 |
| 19 | 2022-01-15 | Louisiana (290) | 68 | 72 | Texas State (199) | Final | L | -4 |
| 20 | 2022-01-20 | South Alabama (177) | 77 | 70 | Louisiana (290) | Final | L | -7 |
| 21 | 2022-01-22 | Troy (127) | 59 | 69 | Louisiana (290) | Final | W | 10 |
| 22 | 2022-01-27 | Georgia State (299) | 68 | 64 | Louisiana (290) | Final | L | -4 |
| 23 | 2022-01-29 | Georgia Southern (216) | 66 | 65 | Louisiana (290) | Final | L | -1 |
| 24 | 2022-02-03 | Louisiana (290) | 75 | 51 | Little Rock (321) | Final | W | 24 |
| 25 | 2022-02-05 | Louisiana (290) | 58 | 67 | Arkansas State (147) | Final | L | -9 |
| 26 | 2022-02-10 | Texas State (199) | 82 | 73 | Louisiana (290) | Final | L | -9 |
| 27 | 2022-02-12 | Texas-Arlington (162) | 80 | 77 | Louisiana (290) | Final/OT | L | -3 |
| 28 | 2022-02-17 | Louisiana (290) | 78 | 77 | Louisiana-Monroe (358) | Final | W | 1 |
| 29 | 2022-02-19 | Louisiana-Monroe (239) | 74 | 79 | Louisiana (230) | Final | W | 5 |
| 30 | 2022-02-23 | Louisiana (214) | 82 | 69 | Georgia Southern (248) | Final | W | 13 |
| 31 | 2022-02-25 | Louisiana (214) | 58 | 65 | Georgia State (185) | Final | L | -7 |
| 32 | 2022-03-03 | Texas-Arlington (238) | 64 | 67 | Louisiana (214) | Final | W | 3 |
| 33 | 2022-03-05 | Louisiana (214) | 79 | 72 | Texas State (111) | Final | W | 7 |
| 34 | 2022-03-06 | Louisiana (195) | 66 | 57 | Troy (167) | Final | W | 9 |
| 35 | 2022-03-07 | Louisiana (195) | 71 | 80 | Georgia State (155) | Final | L | -9 |