Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Alabama State (340) | 72 | 91 | Vanderbilt (131) | Final | W | 19 |
| 2 | 2021-11-14 | Texas State (199) | 60 | 79 | Vanderbilt (17) | Final | W | 19 |
| 3 | 2021-11-17 | Virginia Commonwealth (38) | 48 | 37 | Vanderbilt (17) | Final | L | -11 |
| 4 | 2021-11-20 | Winthrop (133) | 63 | 77 | Vanderbilt (17) | Final | W | 14 |
| 5 | 2021-11-24 | Vanderbilt (17) | 68 | 52 | Pittsburgh (108) | Final | W | 16 |
| 6 | 2021-11-29 | Mississippi Valley State (343) | 36 | 75 | Vanderbilt (73) | Final | W | 39 |
| 7 | 2021-12-04 | Vanderbilt (17) | 72 | 84 | SMU (45) | Final | L | -12 |
| 8 | 2021-12-07 | Temple (169) | 72 | 68 | Vanderbilt (17) | Final/OT | L | -4 |
| 9 | 2021-12-10 | Loyola-Chicago (34) | 69 | 58 | Vanderbilt (100) | Final | L | -11 |
| 10 | 2021-12-18 | Austin Peay (138) | 51 | 77 | Vanderbilt (17) | Final | W | 26 |
| 11 | 2021-12-22 | Vanderbilt (17) | 68 | 54 | Hawaii (109) | Final | W | 14 |
| 12 | 2021-12-23 | BYU (23) | 67 | 69 | Vanderbilt (17) | Final | W | 2 |
| 13 | 2021-12-23 | Vanderbilt (108) | 68 | 54 | Hawaii (231) | Final | W | 14 |
| 14 | 2021-12-25 | Stanford (60) | 0 | 0 | Vanderbilt (17) | Cancelled | - | - |
| 15 | 2022-01-04 | Vanderbilt (17) | 75 | 74 | Arkansas (16) | Final | W | 1 |
| 16 | 2022-01-08 | South Carolina (110) | 72 | 70 | Vanderbilt (17) | Final | L | -2 |
| 17 | 2022-01-11 | Kentucky (26) | 78 | 66 | Vanderbilt (17) | Final | L | -12 |
| 18 | 2022-01-15 | Vanderbilt (17) | 73 | 66 | Georgia (35) | Final | W | 7 |
| 19 | 2022-01-18 | Tennessee (18) | 68 | 60 | Vanderbilt (17) | Final | L | -8 |
| 20 | 2022-01-22 | Vanderbilt (17) | 42 | 61 | Florida (6) | Final | L | -19 |
| 21 | 2022-01-26 | Vanderbilt (85) | 61 | 70 | South Carolina (80) | Final | L | -9 |
| 22 | 2022-01-29 | Georgia (35) | 77 | 85 | Vanderbilt (17) | Final | W | 8 |
| 23 | 2022-02-02 | Vanderbilt (94) | 70 | 77 | Kentucky (11) | Final | L | -7 |
| 24 | 2022-02-05 | LSU (77) | 66 | 75 | Vanderbilt (17) | Final | W | 9 |
| 25 | 2022-02-08 | Missouri (128) | 62 | 70 | Vanderbilt (85) | Final | W | 8 |
| 26 | 2022-02-12 | Vanderbilt (17) | 64 | 73 | Tennessee (18) | Final | L | -9 |
| 27 | 2022-02-16 | Vanderbilt (79) | 80 | 94 | Auburn (3) | Final | L | -14 |
| 28 | 2022-02-19 | Texas A&M (70) | 67 | 72 | Vanderbilt (79) | Final | W | 5 |
| 29 | 2022-02-22 | Alabama (22) | 74 | 72 | Vanderbilt (73) | Final | L | -2 |
| 30 | 2022-02-26 | Vanderbilt (73) | 69 | 74 | Mississippi State (53) | Final | L | -5 |
| 31 | 2022-03-01 | Florida (51) | 82 | 78 | Vanderbilt (79) | Final | L | -4 |
| 32 | 2022-03-05 | Vanderbilt (79) | 63 | 61 | Ole Miss (106) | Final | W | 2 |
| 33 | 2022-03-09 | Georgia (221) | 51 | 86 | Vanderbilt (80) | Final | W | 35 |
| 34 | 2022-03-10 | Vanderbilt (80) | 82 | 76 | Alabama (26) | Final | W | 6 |
| 35 | 2022-03-11 | Vanderbilt (80) | 71 | 77 | Kentucky (6) | Final | L | -6 |
| 36 | 2022-03-15 | Belmont (73) | 71 | 82 | Vanderbilt (72) | Final | W | 11 |
| 37 | 2022-03-20 | Dayton (62) | 68 | 70 | Vanderbilt (72) | Final | W | 2 |
| 38 | 2022-03-22 | Vanderbilt (72) | 73 | 75 | Xavier (42) | Final | L | -2 |