Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Trevecca | 76 | 83 | Ole Miss (60) | Final | W | 7 |
| 2 | 2021-11-09 | New Orleans (293) | 61 | 82 | Ole Miss (60) | Final | W | 21 |
| 3 | 2021-11-12 | Charleston Southern (262) | 68 | 93 | Ole Miss (79) | Final | W | 25 |
| 4 | 2021-11-18 | Marquette (78) | 78 | 72 | Ole Miss (20) | Final | L | -6 |
| 5 | 2021-11-19 | Ole Miss (79) | 74 | 56 | Elon (232) | Final | W | 18 |
| 6 | 2021-11-21 | Boise State (69) | 60 | 50 | Ole Miss (115) | Final | L | -10 |
| 7 | 2021-11-26 | Mississippi Valley State (365) | 58 | 73 | Ole Miss (79) | Final | W | 15 |
| 8 | 2021-11-30 | Rider (290) | 51 | 75 | Ole Miss (125) | Final | W | 24 |
| 9 | 2021-12-04 | Memphis (136) | 63 | 67 | Ole Miss (79) | Final | W | 4 |
| 10 | 2021-12-11 | Western Kentucky (154) | 71 | 48 | Ole Miss (79) | Final | L | -23 |
| 11 | 2021-12-15 | Middle Tennessee (164) | 52 | 62 | Ole Miss (79) | Final | W | 10 |
| 12 | 2021-12-18 | Dayton (66) | 68 | 76 | Ole Miss (79) | Final | W | 8 |
| 13 | 2021-12-21 | Samford (203) | 75 | 73 | Ole Miss (79) | Final | L | -2 |
| 14 | 2021-12-29 | Florida (6) | 0 | 0 | Ole Miss (79) | Postponed | - | - |
| 15 | 2022-01-05 | Ole Miss (79) | 60 | 66 | Tennessee (18) | Final/OT | L | -6 |
| 16 | 2022-01-08 | Mississippi State (100) | 72 | 82 | Ole Miss (79) | Final | W | 10 |
| 17 | 2022-01-11 | Ole Miss (79) | 51 | 67 | Texas A&M (39) | Final | L | -16 |
| 18 | 2022-01-15 | Auburn (37) | 80 | 71 | Ole Miss (79) | Final | L | -9 |
| 19 | 2022-01-18 | Missouri (51) | 78 | 53 | Ole Miss (79) | Final | L | -25 |
| 20 | 2022-01-22 | Ole Miss (79) | 60 | 78 | Mississippi State (100) | Final | L | -18 |
| 21 | 2022-01-24 | Florida (6) | 54 | 70 | Ole Miss (79) | Final | W | 16 |
| 22 | 2022-01-26 | Arkansas (41) | 64 | 55 | Ole Miss (118) | Final | L | -9 |
| 23 | 2022-01-29 | Kansas State (96) | 56 | 67 | Ole Miss (79) | Final | W | 11 |
| 24 | 2022-02-01 | Ole Miss (104) | 76 | 72 | LSU (12) | Final | W | 4 |
| 25 | 2022-02-05 | Ole Miss (79) | 57 | 62 | Florida (6) | Final/OT | L | -5 |
| 26 | 2022-02-09 | Alabama (15) | 97 | 83 | Ole Miss (79) | Final | L | -14 |
| 27 | 2022-02-12 | Ole Miss (79) | 68 | 74 | Missouri (51) | Final | L | -6 |
| 28 | 2022-02-15 | South Carolina (87) | 77 | 74 | Ole Miss (99) | Final (OT) | L | -3 |
| 29 | 2022-02-19 | Ole Miss (99) | 85 | 68 | Georgia (205) | Final | W | 17 |
| 30 | 2022-02-23 | Ole Miss (101) | 64 | 77 | Auburn (3) | Final | L | -13 |
| 31 | 2022-02-26 | Texas A&M (72) | 76 | 66 | Ole Miss (101) | Final | L | -10 |
| 32 | 2022-03-01 | Ole Miss (106) | 72 | 83 | Kentucky (6) | Final | L | -11 |
| 33 | 2022-03-05 | Vanderbilt (79) | 63 | 61 | Ole Miss (106) | Final | L | -2 |
| 34 | 2022-03-09 | Ole Miss (107) | 60 | 72 | Missouri (140) | Final | L | -12 |