Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Drury | 49 | 96 | Drake (43) | Final | W | 47 |
| 2 | 2021-11-09 | Coe College | 61 | 87 | Drake (43) | Final | W | 26 |
| 3 | 2021-11-14 | South Dakota (275) | 50 | 99 | Drake (217) | Final | W | 49 |
| 4 | 2021-11-20 | Richmond (166) | 70 | 73 | Drake (217) | Final | W | 3 |
| 5 | 2021-11-25 | Belmont (68) | 74 | 69 | Drake (217) | Final | L | -5 |
| 6 | 2021-11-26 | Alabama (15) | 80 | 71 | Drake (217) | Final | L | -9 |
| 7 | 2021-11-28 | North Texas (188) | 57 | 54 | Drake (135) | Final | L | -3 |
| 8 | 2021-12-02 | Valparaiso (259) | 66 | 73 | Drake (135) | Final | W | 7 |
| 9 | 2021-12-05 | St. Thomas (256) | 64 | 74 | Drake (135) | Final | W | 10 |
| 10 | 2021-12-08 | Drake (110) | 78 | 70 | Nebraska-Omaha (350) | Final | W | 8 |
| 11 | 2021-12-11 | Drake (217) | 80 | 90 | Clemson (36) | Final/OT | L | -10 |
| 12 | 2021-12-16 | Jackson State (329) | 65 | 70 | Drake (217) | Final/OT | W | 5 |
| 13 | 2021-12-19 | Tennessee-Martin (205) | 54 | 80 | Drake (217) | Final | W | 26 |
| 14 | 2021-12-22 | Chicago State (351) | 50 | 87 | Drake (217) | Final | W | 37 |
| 15 | 2021-12-22 | Saint Louis | 0 | 0 | Drake | Cancelled | - | - |
| 16 | 2021-12-28 | Mount Marty College | 53 | 82 | Drake (97) | Final | W | 29 |
| 17 | 2022-01-02 | Drake (217) | 56 | 61 | Missouri State (224) | Final | L | -5 |
| 18 | 2022-01-05 | Drake (217) | 0 | 0 | Southern Illinois (150) | Postponed | - | - |
| 19 | 2022-01-08 | Drake (217) | 60 | 59 | Evansville (302) | Final | W | 1 |
| 20 | 2022-01-12 | Illinois State (226) | 75 | 86 | Drake (110) | Final | W | 11 |
| 21 | 2022-01-17 | Drake (110) | 60 | 59 | Southern Illinois (187) | Final | W | 1 |
| 22 | 2022-01-19 | Bradley (113) | 83 | 71 | Drake (217) | Final | L | -12 |
| 23 | 2022-01-22 | Drake (217) | 82 | 74 | Northern Iowa (89) | Final/OT | W | 8 |
| 24 | 2022-01-26 | Drake (109) | 89 | 88 | Illinois State (218) | Final (OT) | W | 1 |
| 25 | 2022-01-30 | Loyola-Chicago (42) | 68 | 77 | Drake (97) | Final | W | 9 |
| 26 | 2022-02-02 | Drake (97) | 85 | 67 | Indiana State (219) | Final | W | 18 |
| 27 | 2022-02-05 | Northern Iowa (89) | 74 | 69 | Drake (217) | Final/OT | L | -5 |
| 28 | 2022-02-09 | Missouri State (224) | 66 | 62 | Drake (217) | Final | L | -4 |
| 29 | 2022-02-12 | Drake (217) | 59 | 68 | Bradley (113) | Final | L | -9 |
| 30 | 2022-02-16 | Evansville (312) | 51 | 73 | Drake (110) | Final | W | 22 |
| 31 | 2022-02-19 | Drake (110) | 83 | 76 | Loyola-Chicago (40) | Final | W | 7 |
| 32 | 2022-02-21 | Indiana State (243) | 58 | 74 | Drake (104) | Final | W | 16 |
| 33 | 2022-02-23 | Drake (104) | 71 | 65 | Valparaiso (208) | Final | W | 6 |
| 34 | 2022-02-26 | Southern Illinois (169) | 60 | 62 | Drake (104) | Final | W | 2 |
| 35 | 2022-03-04 | Southern Illinois (164) | 52 | 65 | Drake (92) | Final | W | 13 |
| 36 | 2022-03-05 | Drake (92) | 79 | 78 | Missouri State (91) | Final | W | 1 |
| 37 | 2022-03-06 | Loyola-Chicago (44) | 64 | 58 | Drake (86) | Final | L | -6 |
| 38 | 2022-03-19 | Drake (86) | 87 | 65 | Purdue Fort Wayne (203) | Final | W | 22 |
| 39 | 2022-03-21 | Drake (86) | 75 | 76 | UNC-Wilmington (131) | Final | L | -1 |