Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Bradley (181) | 65 | 81 | South Dakota State (125) | Final | W | 16 |
| 2 | 2021-11-12 | South Dakota State (268) | 88 | 104 | Alabama (15) | Final | L | -16 |
| 3 | 2021-11-14 | South Dakota State (268) | 83 | 71 | Stephen F. Austin (88) | Final | W | 12 |
| 4 | 2021-11-17 | Montana State (197) | 74 | 91 | South Dakota State (268) | Final | W | 17 |
| 5 | 2021-11-18 | Presentation | 62 | 99 | South Dakota State (119) | Final | W | 37 |
| 6 | 2021-11-22 | South Dakota State (268) | 102 | 75 | Nevada (67) | Final | W | 27 |
| 7 | 2021-11-23 | Washington (195) | 87 | 76 | South Dakota State (89) | Final | L | -11 |
| 8 | 2021-11-24 | George Mason (86) | 76 | 80 | South Dakota State (268) | Final | W | 4 |
| 9 | 2021-11-30 | Prairie View A&M (326) | 90 | 99 | South Dakota State (82) | Final | W | 9 |
| 10 | 2021-12-03 | Minnesota-Morris | 47 | 112 | South Dakota State (82) | Final | W | 65 |
| 11 | 2021-12-08 | South Dakota State (73) | 84 | 98 | Idaho (353) | Final | L | -14 |
| 12 | 2021-12-11 | South Dakota State (268) | 77 | 74 | Washington State (179) | Final | W | 3 |
| 13 | 2021-12-15 | South Dakota State (268) | 63 | 75 | Missouri State (224) | Final | L | -12 |
| 14 | 2021-12-20 | UMKC (364) | 57 | 89 | South Dakota State (268) | Final | W | 32 |
| 15 | 2021-12-22 | Oral Roberts (327) | 76 | 82 | South Dakota State (268) | Final | W | 6 |
| 16 | 2021-12-30 | South Dakota State (268) | 90 | 86 | North Dakota State (117) | Final | W | 4 |
| 17 | 2022-01-01 | South Dakota State (268) | 0 | 0 | North Dakota (251) | Postponed | - | - |
| 18 | 2022-01-08 | South Dakota (275) | 65 | 84 | South Dakota State (268) | Final | W | 19 |
| 19 | 2022-01-13 | South Dakota State (268) | 95 | 86 | Nebraska-Omaha (272) | Final | W | 9 |
| 20 | 2022-01-15 | Denver (253) | 62 | 80 | South Dakota State (268) | Final | W | 18 |
| 21 | 2022-01-20 | South Dakota State (268) | 92 | 77 | St. Thomas (137) | Final | W | 15 |
| 22 | 2022-01-22 | South Dakota State (268) | 93 | 75 | Western Illinois (362) | Final | W | 18 |
| 23 | 2022-01-27 | North Dakota (251) | 61 | 96 | South Dakota State (268) | Final | W | 35 |
| 24 | 2022-01-29 | North Dakota State (117) | 76 | 80 | South Dakota State (268) | Final | W | 4 |
| 25 | 2022-01-31 | South Dakota State (62) | 70 | 64 | North Dakota (347) | Final | W | 6 |
| 26 | 2022-02-05 | South Dakota State (268) | 89 | 79 | South Dakota (275) | Final | W | 10 |
| 27 | 2022-02-10 | South Dakota State (268) | 84 | 61 | Denver (253) | Final | W | 23 |
| 28 | 2022-02-12 | Nebraska-Omaha (272) | 61 | 82 | South Dakota State (268) | Final | W | 21 |
| 29 | 2022-02-17 | Western Illinois (362) | 66 | 91 | South Dakota State (268) | Final | W | 25 |
| 30 | 2022-02-19 | St. Thomas (310) | 60 | 79 | South Dakota State (57) | Final | W | 19 |
| 31 | 2022-02-24 | South Dakota State (52) | 106 | 102 | Oral Roberts (142) | Final | W | 4 |
| 32 | 2022-02-26 | South Dakota State (52) | 86 | 75 | UMKC (193) | Final | W | 11 |
| 33 | 2022-03-05 | Nebraska-Omaha (344) | 79 | 87 | South Dakota State (50) | Final | W | 8 |
| 34 | 2022-03-07 | South Dakota (181) | 60 | 83 | South Dakota State (52) | Final | W | 23 |
| 35 | 2022-03-08 | North Dakota State (144) | 69 | 75 | South Dakota State (52) | Final | W | 6 |
| 36 | 2022-03-17 | South Dakota State (50) | 57 | 66 | Providence (14) | Final | L | -9 |