Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Appalachian State (157) | 53 | 65 | Iona (134) | Final | W | 12 |
| 2 | 2021-11-13 | Harvard | 87 | 90 | Iona (134) | Final (OT) | W | 3 |
| 3 | 2021-11-16 | Hofstra (117) | 74 | 82 | Iona (67) | Final | W | 8 |
| 4 | 2021-11-19 | Liberty (93) | 50 | 54 | Iona (220) | Final | W | 4 |
| 5 | 2021-11-20 | Iona (220) | 81 | 65 | North Alabama (335) | Final | W | 16 |
| 6 | 2021-11-25 | Alabama (15) | 68 | 72 | Iona (220) | Final | W | 4 |
| 7 | 2021-11-26 | Iona (220) | 65 | 72 | Belmont (68) | Final | L | -7 |
| 8 | 2021-11-28 | Kansas (28) | 96 | 83 | Iona (53) | Final | L | -13 |
| 9 | 2021-12-01 | Iona (220) | 78 | 71 | Marist (178) | Final | W | 7 |
| 10 | 2021-12-03 | Rider (356) | 54 | 80 | Iona (220) | Final | W | 26 |
| 11 | 2021-12-12 | Yale (81) | 77 | 91 | Iona (220) | Final | W | 14 |
| 12 | 2021-12-18 | Iona (220) | 0 | 0 | Seton Hall (53) | Cancelled | - | - |
| 13 | 2021-12-21 | Delaware (287) | 72 | 83 | Iona (220) | Final | W | 11 |
| 14 | 2021-12-31 | Siena (160) | 0 | 0 | Iona (220) | Postponed | - | - |
| 15 | 2022-01-02 | Marist (178) | 66 | 69 | Iona (220) | Final | W | 3 |
| 16 | 2022-01-07 | Iona (220) | 0 | 0 | Saint Peter's (200) | Postponed | - | - |
| 17 | 2022-01-08 | Iona (220) | 67 | 68 | Saint Louis (31) | Final | L | -1 |
| 18 | 2022-01-11 | Iona (220) | 80 | 76 | Fairfield (204) | Final | W | 4 |
| 19 | 2022-01-14 | Manhattan (154) | 76 | 88 | Iona (45) | Final | W | 12 |
| 20 | 2022-01-16 | Niagara (200) | 55 | 78 | Iona (38) | Final | W | 23 |
| 21 | 2022-01-18 | Iona (220) | 86 | 85 | Monmouth (176) | Final/OT | W | 1 |
| 22 | 2022-01-23 | Iona (40) | 76 | 61 | Quinnipiac (217) | Final | W | 15 |
| 23 | 2022-01-30 | Saint Peter's (183) | 77 | 85 | Iona (31) | Final | W | 8 |
| 24 | 2022-02-04 | Iona (31) | 70 | 62 | Canisius (269) | Final | W | 8 |
| 25 | 2022-02-06 | Iona (220) | 71 | 80 | Niagara (342) | Final | L | -9 |
| 26 | 2022-02-11 | Iona (220) | 64 | 70 | Siena (160) | Final | L | -6 |
| 27 | 2022-02-13 | Monmouth (120) | 62 | 70 | Iona (51) | Final | W | 8 |
| 28 | 2022-02-15 | Iona (51) | 70 | 61 | Saint Peter's (177) | Final | W | 9 |
| 29 | 2022-02-20 | Fairfield (235) | 58 | 76 | Iona (46) | Final | W | 18 |
| 30 | 2022-02-25 | Canisius (276) | 65 | 72 | Iona (46) | Final | W | 7 |
| 31 | 2022-02-27 | Iona (49) | 67 | 61 | Rider (263) | Final | W | 6 |
| 32 | 2022-03-03 | Iona (49) | 72 | 74 | Manhattan (222) | Final | L | -2 |
| 33 | 2022-03-05 | Quinnipiac (244) | 61 | 79 | Iona (49) | Final | W | 18 |
| 34 | 2022-03-09 | Rider (262) | 71 | 70 | Iona (61) | Final | L | -1 |
| 35 | 2022-03-16 | Iona (220) | 74 | 79 | Florida (6) | Final | L | -5 |