Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Mobile | 47 | 72 | Alabama State (340) | Final | W | 25 |
| 2 | 2021-11-09 | Alabama State (340) | 74 | 79 | Western Kentucky (65) | Final | L | -5 |
| 3 | 2021-11-10 | Alabama State (340) | 72 | 91 | Vanderbilt (131) | Final | L | -19 |
| 4 | 2021-11-13 | Alabama State (340) | 60 | 78 | Missouri State (94) | Final | L | -18 |
| 5 | 2021-11-16 | Alabama State (354) | 60 | 68 | Iowa State (50) | Final | L | -8 |
| 6 | 2021-11-18 | Alabama State (354) | 82 | 108 | Iowa (17) | Final | L | -26 |
| 7 | 2021-11-20 | North Carolina Central (341) | 74 | 80 | Alabama State (331) | Final/OT | W | 6 |
| 8 | 2021-11-22 | Tuskegee | 65 | 91 | Alabama State (303) | Final | W | 26 |
| 9 | 2021-11-28 | North Alabama (204) | 81 | 69 | Alabama State (291) | Final | L | -12 |
| 10 | 2021-12-01 | Alabama State (331) | 54 | 93 | Dayton (66) | Final | L | -39 |
| 11 | 2021-12-08 | Samford (181) | 74 | 64 | Alabama State (303) | Final | L | -10 |
| 12 | 2021-12-11 | Alabama State (331) | 62 | 79 | Pepperdine (283) | Final | L | -17 |
| 13 | 2021-12-15 | Alabama State (331) | 0 | 0 | UCLA (30) | Cancelled | - | - |
| 14 | 2021-12-21 | Alabama State (331) | 0 | 0 | Memphis (136) | Cancelled | - | - |
| 15 | 2021-12-22 | Alabama State (331) | 48 | 68 | Texas (41) | Final | L | -20 |
| 16 | 2021-12-28 | Alabama State (331) | 53 | 75 | Texas Tech (20) | Final | L | -22 |
| 17 | 2022-01-03 | Alabama State (331) | 84 | 75 | Mississippi Valley State (365) | Final | W | 9 |
| 18 | 2022-01-05 | Alabama State (331) | 68 | 70 | Arkansas-Pine Bluff (303) | Final | L | -2 |
| 19 | 2022-01-08 | Jackson State (329) | 57 | 72 | Alabama State (331) | Final | W | 15 |
| 20 | 2022-01-10 | Alcorn State (288) | 70 | 60 | Alabama State (311) | Final | L | -10 |
| 21 | 2022-01-15 | Alabama A&M (286) | 55 | 59 | Alabama State (331) | Final | W | 4 |
| 22 | 2022-01-22 | Alabama State (331) | 67 | 70 | Prairie View A&M (285) | Final | L | -3 |
| 23 | 2022-01-24 | Alabama State (331) | 66 | 73 | Texas Southern (317) | Final | L | -7 |
| 24 | 2022-01-29 | Bethune-Cookman (240) | 73 | 79 | Alabama State (331) | Final | W | 6 |
| 25 | 2022-01-31 | Florida A&M (300) | 66 | 65 | Alabama State (339) | Final | L | -1 |
| 26 | 2022-02-05 | Alabama State (331) | 80 | 72 | Grambling (312) | Final | W | 8 |
| 27 | 2022-02-07 | Alabama State (331) | 58 | 72 | Southern (259) | Final | L | -14 |
| 28 | 2022-02-12 | Arkansas-Pine Bluff (303) | 75 | 70 | Alabama State (331) | Final | L | -5 |
| 29 | 2022-02-14 | Mississippi Valley State (365) | 85 | 71 | Alabama State (331) | Final | L | -14 |
| 30 | 2022-02-19 | Alabama State (338) | 83 | 86 | Florida A&M (303) | Final | L | -3 |
| 31 | 2022-02-21 | Alabama State (346) | 89 | 78 | Bethune-Cookman (341) | Final | W | 11 |
| 32 | 2022-02-26 | Alabama State (346) | 65 | 80 | Alabama A&M (337) | Final | L | -15 |
| 33 | 2022-03-03 | Southern (232) | 67 | 77 | Alabama State (343) | Final | W | 10 |
| 34 | 2022-03-05 | Grambling (301) | 75 | 78 | Alabama State (343) | Final | W | 3 |