Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-30 | Pepperdine (104) | 50 | 77 | Point Loma | Final | L | -27 |
| 2 | 2021-11-09 | Pepperdine (104) | 63 | 82 | Rice (190) | Final | L | -19 |
| 3 | 2021-11-12 | Idaho State (289) | 60 | 65 | Pepperdine (283) | Final | W | 5 |
| 4 | 2021-11-15 | Utah Valley (286) | 86 | 74 | Pepperdine (245) | Final (OT) | L | -12 |
| 5 | 2021-11-17 | UC-Davis (170) | 67 | 72 | Pepperdine (283) | Final | W | 5 |
| 6 | 2021-11-20 | Pepperdine (283) | 48 | 82 | UC-Irvine (119) | Final | L | -34 |
| 7 | 2021-11-23 | Fresno State (153) | 70 | 63 | Pepperdine (283) | Final | L | -7 |
| 8 | 2021-11-23 | Pepperdine (228) | 63 | 70 | Fresno State (133) | Final | L | -7 |
| 9 | 2021-11-24 | TCU (32) | 73 | 64 | Pepperdine (283) | Final | L | -9 |
| 10 | 2021-11-27 | Grand Canyon (81) | 59 | 56 | Pepperdine (228) | Final | L | -3 |
| 11 | 2021-11-30 | Pepperdine (280) | 66 | 79 | Nevada (147) | Final | L | -13 |
| 12 | 2021-12-03 | Pepperdine (283) | 74 | 86 | UC-Santa Barbara (171) | Final | L | -12 |
| 13 | 2021-12-06 | San Jose State (153) | 69 | 82 | Pepperdine (293) | Final | W | 13 |
| 14 | 2021-12-11 | Alabama State (331) | 62 | 79 | Pepperdine (283) | Final | W | 17 |
| 15 | 2021-12-18 | Southeast Missouri State (226) | 77 | 83 | Pepperdine (283) | Final | W | 6 |
| 16 | 2021-12-21 | Pepperdine (283) | 59 | 68 | Oregon (102) | Final | L | -9 |
| 17 | 2021-12-23 | Westmont | 69 | 96 | Pepperdine (283) | Final | W | 27 |
| 18 | 2022-01-01 | Pepperdine (283) | 0 | 0 | Pacific (132) | Postponed | - | - |
| 19 | 2022-01-08 | Pepperdine (283) | 83 | 117 | Gonzaga (11) | Final | L | -34 |
| 20 | 2022-01-10 | San Diego (207) | 72 | 62 | Pepperdine (257) | Final | L | -10 |
| 21 | 2022-01-13 | Saint Mary's (33) | 77 | 62 | Pepperdine (283) | Final | L | -15 |
| 22 | 2022-01-15 | Portland (210) | 82 | 63 | Pepperdine (283) | Final | L | -19 |
| 23 | 2022-01-20 | Pepperdine (283) | 80 | 85 | Loyola Marymount (184) | Final/OT | L | -5 |
| 24 | 2022-01-22 | San Francisco (122) | 71 | 45 | Pepperdine (283) | Final | L | -26 |
| 25 | 2022-01-27 | Pepperdine (283) | 56 | 64 | San Diego (246) | Final | L | -8 |
| 26 | 2022-01-29 | Pepperdine (283) | 57 | 81 | Saint Mary's (33) | Final | L | -24 |
| 27 | 2022-02-03 | Pepperdine (283) | 76 | 81 | Pacific (132) | Final | L | -5 |
| 28 | 2022-02-05 | Pacific (132) | 64 | 70 | Pepperdine (283) | Final | W | 6 |
| 29 | 2022-02-10 | Pepperdine (283) | 61 | 105 | San Francisco (122) | Final | L | -44 |
| 30 | 2022-02-12 | BYU (23) | 91 | 85 | Pepperdine (283) | Final | L | -6 |
| 31 | 2022-02-16 | Gonzaga (2) | 86 | 66 | Pepperdine (286) | Final | L | -20 |
| 32 | 2022-02-19 | Pepperdine (286) | 74 | 77 | Portland (200) | Final | L | -3 |
| 33 | 2022-02-24 | Santa Clara (75) | 89 | 73 | Pepperdine (286) | Final | L | -16 |
| 34 | 2022-02-26 | Pepperdine (286) | 59 | 75 | BYU (68) | Final | L | -16 |
| 35 | 2022-03-03 | Pepperdine (287) | 67 | 74 | San Diego (196) | Final | L | -7 |