Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Tennessee State (336) | 73 | 82 | Alabama A&M (317) | Final | W | 9 |
| 2 | 2021-11-13 | Alabama A&M (317) | 47 | 70 | Jacksonville State (152) | Final | L | -23 |
| 3 | 2021-11-16 | Alabama A&M (219) | 66 | 89 | Cincinnati (33) | Final | L | -23 |
| 4 | 2021-11-21 | Alabama A&M (302) | 41 | 86 | UAB (84) | Final | L | -45 |
| 5 | 2021-11-24 | Alabama A&M (286) | 62 | 88 | Western Kentucky (154) | Final | L | -26 |
| 6 | 2021-12-08 | Alabama A&M (315) | 45 | 56 | North Alabama (189) | Final | L | -11 |
| 7 | 2021-12-11 | Alabama A&M (286) | 50 | 52 | Samford (203) | Final | L | -2 |
| 8 | 2021-12-14 | Alabama A&M (286) | 57 | 66 | Troy (127) | Final | L | -9 |
| 9 | 2021-12-18 | Alabama A&M (286) | 43 | 67 | Indiana State (243) | Final | L | -24 |
| 10 | 2021-12-23 | Alabama A&M (286) | 0 | 0 | Georgia Tech (158) | Cancelled | - | - |
| 11 | 2021-12-30 | Alabama A&M (286) | 63 | 66 | Lipscomb (190) | Final | L | -3 |
| 12 | 2022-01-03 | Alabama A&M (286) | 70 | 50 | Arkansas-Pine Bluff (303) | Final | W | 20 |
| 13 | 2022-01-05 | Alabama A&M (286) | 72 | 67 | Mississippi Valley State (365) | Final | W | 5 |
| 14 | 2022-01-08 | Alcorn State (348) | 78 | 71 | Alabama A&M (286) | Final | L | -7 |
| 15 | 2022-01-10 | Jackson State (302) | 58 | 60 | Alabama A&M (326) | Final | W | 2 |
| 16 | 2022-01-15 | Alabama A&M (286) | 55 | 59 | Alabama State (331) | Final | L | -4 |
| 17 | 2022-01-22 | Alabama A&M (286) | 44 | 78 | Texas Southern (317) | Final | L | -34 |
| 18 | 2022-01-24 | Alabama A&M (286) | 48 | 72 | Prairie View A&M (285) | Final | L | -24 |
| 19 | 2022-01-29 | Florida A&M (297) | 65 | 60 | Alabama A&M (286) | Final | L | -5 |
| 20 | 2022-01-31 | Bethune-Cookman (321) | 52 | 67 | Alabama A&M (346) | Final | W | 15 |
| 21 | 2022-02-05 | Alabama A&M (286) | 64 | 73 | Southern (259) | Final | L | -9 |
| 22 | 2022-02-07 | Alabama A&M (286) | 50 | 58 | Grambling (312) | Final | L | -8 |
| 23 | 2022-02-12 | Mississippi Valley State (365) | 92 | 94 | Alabama A&M (286) | Final/4OT | W | 2 |
| 24 | 2022-02-14 | Arkansas-Pine Bluff (303) | 69 | 74 | Alabama A&M (286) | Final | W | 5 |
| 25 | 2022-02-19 | Alabama A&M (343) | 62 | 60 | Bethune-Cookman (329) | Final | W | 2 |
| 26 | 2022-02-21 | Alabama A&M (337) | 71 | 63 | Florida A&M (308) | Final | W | 8 |
| 27 | 2022-02-26 | Alabama State (346) | 65 | 80 | Alabama A&M (337) | Final | W | 15 |
| 28 | 2022-03-03 | Grambling (301) | 63 | 71 | Alabama A&M (325) | Final | W | 8 |
| 29 | 2022-03-05 | Southern (232) | 50 | 49 | Alabama A&M (325) | Final | L | -1 |
| 30 | 2022-03-10 | Alabama A&M (320) | 61 | 56 | Florida A&M (304) | Final | W | 5 |
| 31 | 2022-03-11 | Alabama A&M (320) | 64 | 69 | Alcorn State (259) | Final | L | -5 |