Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Delta State | 0 | 0 | Mississippi Valley State | Cancelled | - | - |
| 2 | 2021-11-09 | Mississippi Valley State (347) | 61 | 119 | St. John's (67) | Final | L | -58 |
| 3 | 2021-11-13 | Mississippi Valley State (347) | 66 | 95 | California Baptist (228) | Final | L | -29 |
| 4 | 2021-11-26 | Mississippi Valley State (365) | 58 | 73 | Ole Miss (79) | Final | L | -15 |
| 5 | 2021-11-29 | Mississippi Valley State (343) | 36 | 75 | Vanderbilt (73) | Final | L | -39 |
| 6 | 2021-12-01 | Mississippi Valley State (365) | 58 | 72 | North Alabama (335) | Final | L | -14 |
| 7 | 2021-12-04 | Mississippi Valley State (365) | 44 | 91 | Grand Canyon (74) | Final | L | -47 |
| 8 | 2021-12-09 | Nicholls State (171) | 95 | 80 | Mississippi Valley State (347) | Final | L | -15 |
| 9 | 2021-12-11 | Arkansas State (147) | 82 | 77 | Mississippi Valley State (365) | Final | L | -5 |
| 10 | 2021-12-18 | Mississippi Valley State (365) | 73 | 104 | Nicholls State (250) | Final | L | -31 |
| 11 | 2021-12-22 | Mississippi Valley State (365) | 58 | 100 | UAB (115) | Final | L | -42 |
| 12 | 2021-12-29 | Mississippi Valley State (365) | 0 | 0 | South Florida (52) | Cancelled | - | - |
| 13 | 2022-01-03 | Alabama State (331) | 84 | 75 | Mississippi Valley State (365) | Final | L | -9 |
| 14 | 2022-01-05 | Alabama A&M (286) | 72 | 67 | Mississippi Valley State (365) | Final | L | -5 |
| 15 | 2022-01-08 | Mississippi Valley State (365) | 84 | 82 | Prairie View A&M (285) | Final/OT | W | 2 |
| 16 | 2022-01-10 | Mississippi Valley State (355) | 58 | 95 | Texas Southern (258) | Final | L | -37 |
| 17 | 2022-01-15 | Bethune-Cookman (240) | 62 | 60 | Mississippi Valley State (365) | Final | L | -2 |
| 18 | 2022-01-17 | Florida A&M (331) | 78 | 70 | Mississippi Valley State (356) | Final | L | -8 |
| 19 | 2022-01-22 | Mississippi Valley State (365) | 64 | 68 | Grambling (312) | Final | L | -4 |
| 20 | 2022-01-24 | Mississippi Valley State (365) | 72 | 100 | Southern (259) | Final | L | -28 |
| 21 | 2022-01-29 | Arkansas-Pine Bluff (303) | 74 | 68 | Mississippi Valley State (365) | Final | L | -6 |
| 22 | 2022-02-05 | Jackson State (329) | 69 | 65 | Mississippi Valley State (365) | Final | L | -4 |
| 23 | 2022-02-07 | Alcorn State (348) | 79 | 71 | Mississippi Valley State (365) | Final | L | -8 |
| 24 | 2022-02-12 | Mississippi Valley State (365) | 92 | 94 | Alabama A&M (286) | Final/4OT | L | -2 |
| 25 | 2022-02-14 | Mississippi Valley State (365) | 85 | 71 | Alabama State (331) | Final | W | 14 |
| 26 | 2022-02-19 | Texas Southern (237) | 79 | 59 | Mississippi Valley State (357) | Final | L | -20 |
| 27 | 2022-02-22 | Prairie View A&M (306) | 69 | 64 | Mississippi Valley State (356) | Final | L | -5 |
| 28 | 2022-02-26 | Mississippi Valley State (356) | 79 | 93 | Arkansas-Pine Bluff (352) | Final | L | -14 |
| 29 | 2022-03-03 | Mississippi Valley State (356) | 69 | 72 | Alcorn State (272) | Final | L | -3 |
| 30 | 2022-03-05 | Mississippi Valley State (356) | 69 | 76 | Jackson State (315) | Final | L | -7 |