Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Jackson State (234) | 47 | 71 | Illinois (3) | Final | L | -24 |
| 2 | 2021-11-12 | Jackson State (329) | 68 | 70 | Louisiana Tech (185) | Final | L | -2 |
| 3 | 2021-11-16 | Jackson State (316) | 64 | 77 | California Baptist (130) | Final | L | -13 |
| 4 | 2021-11-21 | Jackson State (329) | 66 | 80 | Marshall (167) | Final | L | -14 |
| 5 | 2021-11-23 | Jackson State (329) | 35 | 70 | Indiana (17) | Final | L | -35 |
| 6 | 2021-11-27 | Jackson State (329) | 75 | 70 | Louisiana (178) | Final | W | 5 |
| 7 | 2021-11-30 | Jackson State (297) | 54 | 83 | Marquette (35) | Final | L | -29 |
| 8 | 2021-12-04 | Jackson State (329) | 61 | 55 | Illinois State (94) | Final | W | 6 |
| 9 | 2021-12-12 | Jackson State (329) | 37 | 47 | Iowa State (7) | Final | L | -10 |
| 10 | 2021-12-14 | Jackson State (329) | 56 | 66 | Northern Iowa (89) | Final | L | -10 |
| 11 | 2021-12-16 | Jackson State (329) | 65 | 70 | Drake (217) | Final/OT | L | -5 |
| 12 | 2021-12-21 | Jackson State (329) | 0 | 0 | Stephen F. Austin (88) | Cancelled | - | - |
| 13 | 2021-12-29 | Southeast Baptist | 0 | 0 | Jackson State (329) | Cancelled | - | - |
| 14 | 2022-01-05 | Alcorn State (348) | 65 | 50 | Jackson State (329) | Final | L | -15 |
| 15 | 2022-01-08 | Jackson State (329) | 57 | 72 | Alabama State (331) | Final | L | -15 |
| 16 | 2022-01-10 | Jackson State (302) | 58 | 60 | Alabama A&M (326) | Final | L | -2 |
| 17 | 2022-01-15 | Prairie View A&M (285) | 64 | 75 | Jackson State (329) | Final | W | 11 |
| 18 | 2022-01-17 | Texas Southern (256) | 58 | 61 | Jackson State (305) | Final | W | 3 |
| 19 | 2022-01-22 | Jackson State (329) | 50 | 55 | Bethune-Cookman (240) | Final | L | -5 |
| 20 | 2022-01-24 | Jackson State (329) | 64 | 67 | Florida A&M (297) | Final | L | -3 |
| 21 | 2022-01-29 | Grambling (312) | 73 | 64 | Jackson State (329) | Final | L | -9 |
| 22 | 2022-01-31 | Southern (217) | 75 | 64 | Jackson State (322) | Final | L | -11 |
| 23 | 2022-02-05 | Jackson State (329) | 69 | 65 | Mississippi Valley State (365) | Final | W | 4 |
| 24 | 2022-02-07 | Jackson State (329) | 60 | 47 | Arkansas-Pine Bluff (303) | Final | W | 13 |
| 25 | 2022-02-12 | Florida A&M (297) | 56 | 60 | Jackson State (329) | Final | W | 4 |
| 26 | 2022-02-14 | Bethune-Cookman (240) | 51 | 71 | Jackson State (329) | Final | W | 20 |
| 27 | 2022-02-19 | Jackson State (316) | 60 | 61 | Alcorn State (291) | Final | L | -1 |
| 28 | 2022-02-26 | Jackson State (311) | 66 | 81 | Texas Southern (238) | Final | L | -15 |
| 29 | 2022-02-28 | Jackson State (315) | 59 | 53 | Prairie View A&M (306) | Final | W | 6 |
| 30 | 2022-03-03 | Arkansas-Pine Bluff (351) | 79 | 87 | Jackson State (315) | Final | W | 8 |
| 31 | 2022-03-05 | Mississippi Valley State (356) | 69 | 76 | Jackson State (315) | Final | W | 7 |
| 32 | 2022-03-09 | Jackson State (302) | 50 | 54 | Texas Southern (233) | Final | L | -4 |