Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Slippery Rock | 47 | 99 | Iowa (7) | Final | W | 52 |
| 2 | 2021-11-09 | Longwood (283) | 73 | 106 | Iowa (7) | Final | W | 33 |
| 3 | 2021-11-12 | UMKC (364) | 57 | 89 | Iowa (28) | Final | W | 32 |
| 4 | 2021-11-16 | North Carolina Central (340) | 69 | 86 | Iowa (17) | Final | W | 17 |
| 5 | 2021-11-18 | Alabama State (354) | 82 | 108 | Iowa (17) | Final | W | 26 |
| 6 | 2021-11-22 | Western Michigan (304) | 61 | 109 | Iowa (28) | Final | W | 48 |
| 7 | 2021-11-26 | Portland State (192) | 51 | 85 | Iowa (28) | Final | W | 34 |
| 8 | 2021-11-29 | Iowa (17) | 75 | 74 | Virginia (75) | Final | W | 1 |
| 9 | 2021-12-03 | Iowa (28) | 70 | 77 | Purdue (8) | Final | L | -7 |
| 10 | 2021-12-06 | Illinois (53) | 87 | 83 | Iowa (23) | Final | L | -4 |
| 11 | 2021-12-09 | Iowa (23) | 53 | 73 | Iowa State (7) | Final | L | -20 |
| 12 | 2021-12-18 | Utah State (25) | 75 | 94 | Iowa (28) | Final | W | 19 |
| 13 | 2021-12-21 | Southeastern Louisiana (318) | 62 | 93 | Iowa (28) | Final | W | 31 |
| 14 | 2021-12-29 | Western Illinois (362) | 71 | 92 | Iowa (28) | Final | W | 21 |
| 15 | 2022-01-03 | Maryland (114) | 75 | 80 | Iowa (28) | Final | W | 5 |
| 16 | 2022-01-06 | Iowa (28) | 78 | 87 | Wisconsin (24) | Final | L | -9 |
| 17 | 2022-01-13 | Indiana (46) | 74 | 83 | Iowa (28) | Final | W | 9 |
| 18 | 2022-01-16 | Iowa (25) | 81 | 71 | Minnesota (55) | Final | W | 10 |
| 19 | 2022-01-19 | Iowa (28) | 46 | 48 | Rutgers (112) | Final | L | -2 |
| 20 | 2022-01-22 | Penn State (129) | 51 | 68 | Iowa (28) | Final | W | 17 |
| 21 | 2022-01-27 | Purdue (8) | 83 | 73 | Iowa (28) | Final | L | -10 |
| 22 | 2022-01-31 | Iowa (32) | 86 | 90 | Penn State (91) | Final (2OT) | L | -4 |
| 23 | 2022-02-03 | Iowa (28) | 0 | 0 | Ohio State (34) | Postponed | - | - |
| 24 | 2022-02-06 | Minnesota (87) | 59 | 71 | Iowa (28) | Final | W | 12 |
| 25 | 2022-02-10 | Iowa (28) | 110 | 87 | Maryland (114) | Final | W | 23 |
| 26 | 2022-02-13 | Nebraska (188) | 75 | 98 | Iowa (30) | Final | W | 23 |
| 27 | 2022-02-17 | Michigan (1) | 84 | 79 | Iowa (28) | Final | L | -5 |
| 28 | 2022-02-19 | Iowa (30) | 75 | 62 | Ohio State (27) | Final | W | 13 |
| 29 | 2022-02-22 | Michigan State (26) | 60 | 86 | Iowa (28) | Final | W | 26 |
| 30 | 2022-02-25 | Iowa (28) | 88 | 78 | Nebraska (194) | Final | W | 10 |
| 31 | 2022-02-28 | Northwestern (95) | 61 | 82 | Iowa (26) | Final | W | 21 |
| 32 | 2022-03-03 | Iowa (26) | 82 | 71 | Michigan (45) | Final | W | 11 |
| 33 | 2022-03-06 | Iowa (25) | 72 | 74 | Illinois (17) | Final | L | -2 |
| 34 | 2022-03-10 | Northwestern (93) | 76 | 112 | Iowa (25) | Final | W | 36 |
| 35 | 2022-03-11 | Iowa (25) | 84 | 74 | Rutgers (63) | Final | W | 10 |
| 36 | 2022-03-12 | Indiana (54) | 77 | 80 | Iowa (25) | Final | W | 3 |
| 37 | 2022-03-13 | Iowa (16) | 75 | 66 | Purdue (11) | Final | W | 9 |
| 38 | 2022-03-17 | Richmond (77) | 67 | 63 | Iowa (16) | Final | L | -4 |