Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | North Carolina Central (332) | 60 | 70 | Richmond (75) | Final | L | -10 |
| 2 | 2021-11-13 | North Carolina Central (332) | 51 | 90 | Memphis (48) | Final | L | -39 |
| 3 | 2021-11-16 | North Carolina Central (340) | 69 | 86 | Iowa (17) | Final | L | -17 |
| 4 | 2021-11-20 | North Carolina Central (341) | 74 | 80 | Alabama State (331) | Final/OT | L | -6 |
| 5 | 2021-11-23 | Warren Wilson | 32 | 110 | North Carolina Central (328) | Final | W | 78 |
| 6 | 2021-11-27 | Apprentice | 56 | 96 | North Carolina Central (328) | Final | W | 40 |
| 7 | 2021-11-29 | North Carolina Central (289) | 58 | 83 | Gardner-Webb (193) | Final | L | -25 |
| 8 | 2021-12-01 | North Carolina Central (341) | 67 | 65 | South Carolina Upstate (293) | Final | W | 2 |
| 9 | 2021-12-04 | North Carolina Central (341) | 66 | 82 | UNC-Asheville (244) | Final | L | -16 |
| 10 | 2021-12-06 | North Carolina Central (298) | 67 | 80 | The Citadel (194) | Final | L | -13 |
| 11 | 2021-12-09 | Carver Bible | 50 | 102 | North Carolina Central (298) | Final | W | 52 |
| 12 | 2021-12-15 | Gardner-Webb (363) | 71 | 72 | North Carolina Central (341) | Final | W | 1 |
| 13 | 2021-12-18 | North Carolina Central (341) | 86 | 53 | Delaware State (361) | Final | W | 33 |
| 14 | 2021-12-18 | North Carolina Central (300) | 0 | 0 | Hampton (319) | Cancelled | - | - |
| 15 | 2021-12-21 | North Carolina Central (341) | 61 | 70 | UTEP (274) | Final | L | -9 |
| 16 | 2021-12-22 | Sam Houston State (120) | 68 | 51 | North Carolina Central (341) | Final | L | -17 |
| 17 | 2022-01-05 | Mid-Atlantic | 0 | 0 | North Carolina Central (341) | Canceled | - | - |
| 18 | 2022-01-08 | Morgan State (337) | 0 | 0 | North Carolina Central (341) | Canceled | - | - |
| 19 | 2022-01-15 | North Carolina Central (341) | 0 | 0 | South Carolina State (355) | Postponed | - | - |
| 20 | 2022-01-22 | North Carolina Central (341) | 73 | 49 | Delaware State (361) | Final | W | 24 |
| 21 | 2022-01-24 | North Carolina Central (341) | 75 | 63 | Maryland-Eastern Shore (353) | Final | W | 12 |
| 22 | 2022-01-29 | Howard (211) | 75 | 74 | North Carolina Central (341) | Final/OT | L | -1 |
| 23 | 2022-01-31 | Norfolk State (134) | 67 | 70 | North Carolina Central (280) | Final | W | 3 |
| 24 | 2022-02-05 | Coppin State (360) | 68 | 69 | North Carolina Central (341) | Final | W | 1 |
| 25 | 2022-02-07 | North Carolina Central (341) | 68 | 74 | South Carolina State (355) | Final | L | -6 |
| 26 | 2022-02-10 | Warren Wilson | 43 | 115 | North Carolina Central (341) | Final | W | 72 |
| 27 | 2022-02-12 | North Carolina Central (341) | 74 | 64 | Morgan State (337) | Final | W | 10 |
| 28 | 2022-02-14 | North Carolina Central (341) | 77 | 74 | Coppin State (360) | Final | W | 3 |
| 29 | 2022-02-19 | Delaware State (356) | 79 | 84 | North Carolina Central (260) | Final | W | 5 |
| 30 | 2022-02-21 | Maryland-Eastern Shore (302) | 79 | 66 | North Carolina Central (250) | Final | L | -13 |
| 31 | 2022-02-26 | North Carolina Central (250) | 67 | 77 | Howard (240) | Final | L | -10 |
| 32 | 2022-02-28 | North Carolina Central (275) | 46 | 75 | Norfolk State (171) | Final | L | -29 |
| 33 | 2022-03-03 | South Carolina State (290) | 62 | 67 | North Carolina Central (275) | Final | W | 5 |
| 34 | 2022-03-10 | Maryland-Eastern Shore (295) | 56 | 68 | North Carolina Central (270) | Final | W | 12 |
| 35 | 2022-03-11 | Coppin State (319) | 79 | 73 | North Carolina Central (270) | Final | L | -6 |