Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Xavier (LA) | 0 | 0 | Alcorn State (329) | Cancelled | - | - |
| 2 | 2021-11-09 | Alcorn State (329) | 67 | 85 | Washington State (101) | Final | L | -18 |
| 3 | 2021-11-10 | Alcorn State (329) | 66 | 69 | Seattle (237) | Final | L | -3 |
| 4 | 2021-11-13 | Alcorn State (329) | 58 | 62 | Portland (310) | Final | L | -4 |
| 5 | 2021-11-15 | Alcorn State (343) | 57 | 84 | Gonzaga (3) | Final | L | -27 |
| 6 | 2021-11-26 | Alcorn State (348) | 59 | 62 | Southern Illinois (150) | Final | L | -3 |
| 7 | 2021-11-28 | Alcorn State (279) | 61 | 57 | Milwaukee (327) | Final | W | 4 |
| 8 | 2021-12-04 | Alcorn State (348) | 64 | 85 | Tulane (167) | Final | L | -21 |
| 9 | 2021-12-06 | Alcorn State (305) | 45 | 77 | Houston (10) | Final | L | -32 |
| 10 | 2021-12-14 | Alcorn State (348) | 63 | 82 | Wichita State (76) | Final | L | -19 |
| 11 | 2021-12-16 | Alcorn State (348) | 62 | 83 | Tulsa (55) | Final | L | -21 |
| 12 | 2021-12-20 | Alcorn State (348) | 57 | 94 | Baylor (58) | Final | L | -37 |
| 13 | 2021-12-22 | Alcorn State (348) | 48 | 72 | Oklahoma (47) | Final | L | -24 |
| 14 | 2021-12-29 | Alcorn State (348) | 0 | 0 | Minnesota (87) | Cancelled | - | - |
| 15 | 2022-01-05 | Alcorn State (348) | 65 | 50 | Jackson State (329) | Final | W | 15 |
| 16 | 2022-01-08 | Alcorn State (348) | 78 | 71 | Alabama A&M (286) | Final | W | 7 |
| 17 | 2022-01-10 | Alcorn State (288) | 70 | 60 | Alabama State (311) | Final | W | 10 |
| 18 | 2022-01-15 | Texas Southern (317) | 72 | 73 | Alcorn State (348) | Final | W | 1 |
| 19 | 2022-01-17 | Prairie View A&M (347) | 74 | 73 | Alcorn State (271) | Final | L | -1 |
| 20 | 2022-01-22 | Alcorn State (348) | 68 | 70 | Florida A&M (297) | Final | L | -2 |
| 21 | 2022-01-24 | Alcorn State (348) | 70 | 67 | Bethune-Cookman (240) | Final | W | 3 |
| 22 | 2022-01-29 | Southern (259) | 64 | 68 | Alcorn State (348) | Final | W | 4 |
| 23 | 2022-01-31 | Grambling (299) | 80 | 73 | Alcorn State (273) | Final | L | -7 |
| 24 | 2022-02-05 | Alcorn State (348) | 70 | 64 | Arkansas-Pine Bluff (303) | Final | W | 6 |
| 25 | 2022-02-07 | Alcorn State (348) | 79 | 71 | Mississippi Valley State (365) | Final | W | 8 |
| 26 | 2022-02-12 | Bethune-Cookman (240) | 71 | 63 | Alcorn State (348) | Final/OT | L | -8 |
| 27 | 2022-02-14 | Florida A&M (297) | 56 | 68 | Alcorn State (348) | Final | W | 12 |
| 28 | 2022-02-14 | Florida A&M (303) | 58 | 68 | Alcorn State (291) | Final | W | 10 |
| 29 | 2022-02-19 | Jackson State (316) | 60 | 61 | Alcorn State (291) | Final | W | 1 |
| 30 | 2022-02-26 | Alcorn State (272) | 72 | 69 | Prairie View A&M (306) | Final | W | 3 |
| 31 | 2022-02-28 | Alcorn State (272) | 75 | 72 | Texas Southern (230) | Final | W | 3 |
| 32 | 2022-03-03 | Mississippi Valley State (356) | 69 | 72 | Alcorn State (272) | Final | W | 3 |
| 33 | 2022-03-05 | Arkansas-Pine Bluff (351) | 77 | 100 | Alcorn State (272) | Final | W | 23 |
| 34 | 2022-03-09 | Prairie View A&M (313) | 63 | 64 | Alcorn State (259) | Final | W | 1 |
| 35 | 2022-03-11 | Alabama A&M (320) | 64 | 69 | Alcorn State (259) | Final | W | 5 |
| 36 | 2022-03-12 | Texas Southern (233) | 87 | 62 | Alcorn State (259) | Final | L | -25 |
| 37 | 2022-03-15 | Alcorn State (261) | 62 | 74 | Texas A&M (38) | Final | L | -12 |