Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Grambling (285) | 53 | 74 | Grand Canyon (108) | Final | L | -21 |
| 2 | 2021-11-12 | Grambling (312) | 62 | 88 | Texas Tech (20) | Final | L | -26 |
| 3 | 2021-11-15 | Grambling (319) | 61 | 86 | New Mexico (172) | Final | L | -25 |
| 4 | 2021-11-21 | Grambling (334) | 47 | 82 | Iowa State (60) | Final | L | -35 |
| 5 | 2021-11-24 | Louisiana Christian | 61 | 71 | Grambling (312) | Final | W | 10 |
| 6 | 2021-11-28 | Grambling (298) | 74 | 59 | Morgan State (284) | Final | W | 15 |
| 7 | 2021-11-30 | Norfolk State (113) | 70 | 63 | Grambling (298) | Final | L | -7 |
| 8 | 2021-12-02 | Jarvis Christian | 44 | 71 | Grambling (298) | Final | W | 27 |
| 9 | 2021-12-04 | Grambling (312) | 59 | 88 | Connecticut (4) | Final | L | -29 |
| 10 | 2021-12-11 | Grambling (312) | 62 | 72 | Incarnate Word (280) | Final | L | -10 |
| 11 | 2021-12-14 | Grambling (312) | 61 | 79 | UAB (115) | Final | L | -18 |
| 12 | 2021-12-18 | Grambling (312) | 0 | 0 | Tulane (167) | Cancelled | - | - |
| 13 | 2021-12-21 | Grambling (312) | 55 | 90 | TCU (32) | Final | L | -35 |
| 14 | 2021-12-28 | Grambling (312) | 64 | 75 | Southern Illinois (150) | Final | L | -11 |
| 15 | 2022-01-03 | Prairie View A&M (285) | 0 | 2 | Grambling (312) | Forfeit | W | 2 |
| 16 | 2022-01-05 | Texas Southern (317) | 67 | 61 | Grambling (312) | Final | L | -6 |
| 17 | 2022-01-08 | Grambling (312) | 68 | 66 | Bethune-Cookman (240) | Final | W | 2 |
| 18 | 2022-01-10 | Grambling (325) | 66 | 75 | Florida A&M (350) | Final | L | -9 |
| 19 | 2022-01-15 | Southern (259) | 77 | 83 | Grambling (312) | Final | W | 6 |
| 20 | 2022-01-22 | Mississippi Valley State (365) | 64 | 68 | Grambling (312) | Final | W | 4 |
| 21 | 2022-01-24 | Arkansas-Pine Bluff (303) | 65 | 76 | Grambling (312) | Final | W | 11 |
| 22 | 2022-01-29 | Grambling (312) | 73 | 64 | Jackson State (329) | Final | W | 9 |
| 23 | 2022-01-31 | Grambling (299) | 80 | 73 | Alcorn State (273) | Final | W | 7 |
| 24 | 2022-02-05 | Alabama State (331) | 80 | 72 | Grambling (312) | Final | L | -8 |
| 25 | 2022-02-07 | Alabama A&M (286) | 50 | 58 | Grambling (312) | Final | W | 8 |
| 26 | 2022-02-12 | Grambling (312) | 65 | 68 | Texas Southern (317) | Final | L | -3 |
| 27 | 2022-02-14 | Grambling (312) | 70 | 71 | Prairie View A&M (285) | Final | L | -1 |
| 28 | 2022-02-19 | Grambling (297) | 61 | 57 | Southern (220) | Final | W | 4 |
| 29 | 2022-02-26 | Florida A&M (308) | 79 | 73 | Grambling (297) | Final | L | -6 |
| 30 | 2022-02-28 | Bethune-Cookman (341) | 69 | 63 | Grambling (301) | Final | L | -6 |
| 31 | 2022-03-03 | Grambling (301) | 63 | 71 | Alabama A&M (325) | Final | L | -8 |
| 32 | 2022-03-05 | Grambling (301) | 75 | 78 | Alabama State (343) | Final | L | -3 |
| 33 | 2022-03-10 | Grambling (317) | 60 | 58 | Southern (232) | Final | W | 2 |
| 34 | 2022-03-11 | Grambling (317) | 54 | 73 | Texas Southern (233) | Final | L | -19 |