Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Campbellsville - Harrodsburg | 61 | 82 | Western Kentucky (65) | Final | W | 21 |
| 2 | 2021-11-05 | Cumberlands (KY) | 59 | 88 | Western Kentucky (65) | Final | W | 29 |
| 3 | 2021-11-09 | Alabama State (340) | 74 | 79 | Western Kentucky (65) | Final | W | 5 |
| 4 | 2021-11-12 | Western Kentucky (154) | 69 | 73 | Minnesota (87) | Final | L | -4 |
| 5 | 2021-11-14 | Western Kentucky (154) | 64 | 75 | South Carolina (110) | Final | L | -11 |
| 6 | 2021-11-19 | Western Kentucky (154) | 62 | 74 | Memphis (136) | Final | L | -12 |
| 7 | 2021-11-24 | Alabama A&M (286) | 62 | 88 | Western Kentucky (154) | Final | W | 26 |
| 8 | 2021-11-27 | Tennessee-Martin (270) | 66 | 81 | Western Kentucky (206) | Final | W | 15 |
| 9 | 2021-11-30 | Rhodes College | 35 | 105 | Western Kentucky (132) | Final | W | 70 |
| 10 | 2021-12-04 | Eastern Kentucky (288) | 80 | 85 | Western Kentucky (154) | Final | W | 5 |
| 11 | 2021-12-08 | Buffalo (152) | 77 | 67 | Western Kentucky (132) | Final | L | -10 |
| 12 | 2021-12-11 | Western Kentucky (154) | 71 | 48 | Ole Miss (79) | Final | W | 23 |
| 13 | 2021-12-14 | Centre | 52 | 90 | Western Kentucky (154) | Final | W | 38 |
| 14 | 2021-12-18 | Louisville (21) | 72 | 82 | Western Kentucky (154) | Final | W | 10 |
| 15 | 2021-12-22 | Western Kentucky (154) | 60 | 95 | Kentucky (26) | Final | L | -35 |
| 16 | 2021-12-22 | Western Kentucky (99) | 0 | 0 | Austin Peay (286) | Cancelled | - | - |
| 17 | 2021-12-30 | Western Kentucky (154) | 0 | 0 | Southern Miss (201) | Postponed | - | - |
| 18 | 2022-01-01 | Western Kentucky (154) | 73 | 74 | Louisiana Tech (185) | Final | L | -1 |
| 19 | 2022-01-08 | Florida International (214) | 71 | 84 | Western Kentucky (154) | Final | W | 13 |
| 20 | 2022-01-13 | Rice (228) | 66 | 80 | Western Kentucky (154) | Final | W | 14 |
| 21 | 2022-01-15 | North Texas (125) | 65 | 60 | Western Kentucky (154) | Final | L | -5 |
| 22 | 2022-01-20 | Western Kentucky (154) | 69 | 78 | Florida Atlantic (128) | Final | L | -9 |
| 23 | 2022-01-22 | Western Kentucky (154) | 83 | 86 | Florida International (214) | Final | L | -3 |
| 24 | 2022-01-27 | UAB (115) | 68 | 65 | Western Kentucky (154) | Final | L | -3 |
| 25 | 2022-01-29 | Middle Tennessee (164) | 93 | 85 | Western Kentucky (154) | Final | L | -8 |
| 26 | 2022-02-03 | Western Kentucky (154) | 78 | 59 | Charlotte (173) | Final | W | 19 |
| 27 | 2022-02-05 | Western Kentucky (154) | 77 | 60 | Old Dominion (254) | Final | W | 17 |
| 28 | 2022-02-10 | Florida Atlantic (128) | 69 | 76 | Western Kentucky (154) | Final | W | 7 |
| 29 | 2022-02-12 | Western Kentucky (154) | 71 | 65 | UTSA (344) | Final | W | 6 |
| 30 | 2022-02-14 | Western Kentucky (154) | 87 | 77 | Southern Miss (201) | Final | W | 10 |
| 31 | 2022-02-17 | Charlotte (173) | 67 | 77 | Western Kentucky (154) | Final | W | 10 |
| 32 | 2022-02-19 | Old Dominion (216) | 64 | 73 | Western Kentucky (130) | Final | W | 9 |
| 33 | 2022-02-26 | Western Kentucky (122) | 52 | 69 | Middle Tennessee (105) | Final | L | -17 |
| 34 | 2022-03-02 | Western Kentucky (124) | 86 | 72 | Marshall (241) | Final | W | 14 |
| 35 | 2022-03-05 | Marshall (241) | 69 | 78 | Western Kentucky (124) | Final | W | 9 |
| 36 | 2022-03-10 | Louisiana Tech (108) | 59 | 57 | Western Kentucky (121) | Final | L | -2 |