Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Bethune-Cookman | 54 | 75 | South Florida (164) | Final | L | -21 |
| 2 | 2021-11-12 | Bethune-Cookman (240) | 51 | 71 | Middle Tennessee (164) | Final | L | -20 |
| 3 | 2021-11-15 | Bethune-Cookman (342) | 55 | 86 | Utah (42) | Final | L | -31 |
| 4 | 2021-11-20 | Bryant (349) | 75 | 81 | Bethune-Cookman (240) | Final | W | 6 |
| 5 | 2021-11-21 | Air Force (102) | 73 | 65 | Bethune-Cookman (290) | Final | L | -8 |
| 6 | 2021-11-23 | Bethune-Cookman (290) | 51 | 59 | Liberty (236) | Final | L | -8 |
| 7 | 2021-11-28 | Bethune-Cookman (296) | 70 | 84 | Seton Hall (43) | Final | L | -14 |
| 8 | 2021-12-05 | Bethune-Cookman (296) | 45 | 81 | Central Florida (90) | Final | L | -36 |
| 9 | 2021-12-09 | Bethune-Cookman (309) | 48 | 65 | North Carolina State (90) | Final | L | -17 |
| 10 | 2021-12-15 | Johnson (FL) | 41 | 88 | Bethune-Cookman (311) | Final | W | 47 |
| 11 | 2021-12-19 | Bethune-Cookman (240) | 0 | 0 | Florida International (214) | Cancelled | - | - |
| 12 | 2021-12-22 | Bethune-Cookman (240) | 45 | 68 | Marist (178) | Final | L | -23 |
| 13 | 2021-12-29 | Florida National | 0 | 0 | Bethune-Cookman (240) | Cancelled | - | - |
| 14 | 2021-12-29 | Fort Lauderdale | 0 | 0 | Bethune-Cookman (319) | Cancelled | - | - |
| 15 | 2022-01-03 | Florida A&M (297) | 59 | 66 | Bethune-Cookman (240) | Final | W | 7 |
| 16 | 2022-01-05 | Bethune-Cookman (240) | 65 | 68 | Florida International (214) | Final | L | -3 |
| 17 | 2022-01-08 | Grambling (312) | 68 | 66 | Bethune-Cookman (240) | Final | L | -2 |
| 18 | 2022-01-10 | Southern (212) | 69 | 59 | Bethune-Cookman (323) | Final | L | -10 |
| 19 | 2022-01-15 | Bethune-Cookman (240) | 62 | 60 | Mississippi Valley State (365) | Final | W | 2 |
| 20 | 2022-01-17 | Bethune-Cookman (322) | 63 | 69 | Arkansas-Pine Bluff (352) | Final | L | -6 |
| 21 | 2022-01-22 | Jackson State (329) | 50 | 55 | Bethune-Cookman (240) | Final | W | 5 |
| 22 | 2022-01-24 | Alcorn State (348) | 70 | 67 | Bethune-Cookman (240) | Final | L | -3 |
| 23 | 2022-01-29 | Bethune-Cookman (240) | 73 | 79 | Alabama State (331) | Final | L | -6 |
| 24 | 2022-01-31 | Bethune-Cookman (321) | 52 | 67 | Alabama A&M (346) | Final | L | -15 |
| 25 | 2022-02-05 | Prairie View A&M (285) | 67 | 68 | Bethune-Cookman (240) | Final | W | 1 |
| 26 | 2022-02-07 | Texas Southern (317) | 66 | 63 | Bethune-Cookman (240) | Final | L | -3 |
| 27 | 2022-02-12 | Bethune-Cookman (240) | 71 | 63 | Alcorn State (348) | Final/OT | W | 8 |
| 28 | 2022-02-14 | Bethune-Cookman (240) | 51 | 71 | Jackson State (329) | Final | L | -20 |
| 29 | 2022-02-19 | Alabama A&M (343) | 62 | 60 | Bethune-Cookman (329) | Final | L | -2 |
| 30 | 2022-02-21 | Alabama State (346) | 89 | 78 | Bethune-Cookman (341) | Final | L | -11 |
| 31 | 2022-02-26 | Bethune-Cookman (341) | 87 | 84 | Southern (225) | Final | W | 3 |
| 32 | 2022-02-28 | Bethune-Cookman (341) | 69 | 63 | Grambling (301) | Final | W | 6 |
| 33 | 2022-03-05 | Bethune-Cookman (341) | 73 | 84 | Florida A&M (309) | Final | L | -11 |