Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-24 | Montevallo | 0 | 0 | Samford (267) | Cancelled | - | - |
| 2 | 2021-11-09 | Maryville | 78 | 99 | Samford (267) | Final | W | 21 |
| 3 | 2021-11-11 | Spring Hill | 69 | 86 | Samford (267) | Final | W | 17 |
| 4 | 2021-11-15 | Samford (202) | 55 | 77 | San Francisco (19) | Final | L | -22 |
| 5 | 2021-11-18 | Samford (202) | 78 | 77 | Oregon State (152) | Final | W | 1 |
| 6 | 2021-11-26 | Samford (203) | 77 | 75 | North Carolina A&T (294) | Final | W | 2 |
| 7 | 2021-11-27 | McNeese State (285) | 75 | 83 | Samford (196) | Final | W | 8 |
| 8 | 2021-11-30 | Mississippi College | 58 | 83 | Samford (143) | Final | W | 25 |
| 9 | 2021-12-05 | Belmont (76) | 85 | 73 | Samford (143) | Final | L | -12 |
| 10 | 2021-12-08 | Samford (181) | 74 | 64 | Alabama State (303) | Final | W | 10 |
| 11 | 2021-12-11 | Alabama A&M (286) | 50 | 52 | Samford (203) | Final | W | 2 |
| 12 | 2021-12-18 | Kennesaw State (142) | 84 | 85 | Samford (203) | Final | W | 1 |
| 13 | 2021-12-21 | Samford (203) | 75 | 73 | Ole Miss (79) | Final | W | 2 |
| 14 | 2021-12-29 | Samford (203) | 49 | 81 | Furman (157) | Final | L | -32 |
| 15 | 2022-01-01 | The Citadel (332) | 0 | 0 | Samford (203) | Postponed | - | - |
| 16 | 2022-01-05 | Samford (203) | 80 | 83 | Mercer (174) | Final | L | -3 |
| 17 | 2022-01-08 | Western Carolina (223) | 60 | 85 | Samford (203) | Final | W | 25 |
| 18 | 2022-01-12 | Samford (159) | 64 | 87 | Wofford (129) | Final | L | -23 |
| 19 | 2022-01-15 | East Tennessee State (140) | 88 | 85 | Samford (203) | Final | L | -3 |
| 20 | 2022-01-20 | Samford (203) | 80 | 99 | Virginia Military (357) | Final | L | -19 |
| 21 | 2022-01-22 | Samford (203) | 58 | 61 | UNC-Greensboro (265) | Final | L | -3 |
| 22 | 2022-01-26 | Mercer (172) | 61 | 75 | Samford (216) | Final | W | 14 |
| 23 | 2022-01-29 | Samford (203) | 74 | 64 | Western Carolina (223) | Final | W | 10 |
| 24 | 2022-02-02 | Chattanooga (55) | 72 | 80 | Samford (200) | Final | W | 8 |
| 25 | 2022-02-05 | Samford (203) | 93 | 107 | The Citadel (332) | Final | L | -14 |
| 26 | 2022-02-09 | Wofford (221) | 60 | 65 | Samford (203) | Final/OT | W | 5 |
| 27 | 2022-02-12 | Samford (203) | 77 | 73 | East Tennessee State (140) | Final | W | 4 |
| 28 | 2022-02-17 | Virginia Military (357) | 99 | 100 | Samford (203) | Final/OT | W | 1 |
| 29 | 2022-02-19 | UNC-Greensboro (160) | 49 | 55 | Samford (172) | Final | W | 6 |
| 30 | 2022-02-21 | The Citadel (236) | 74 | 76 | Samford (158) | Final | W | 2 |
| 31 | 2022-02-23 | Furman (99) | 75 | 83 | Samford (158) | Final | W | 8 |
| 32 | 2022-02-26 | Samford (158) | 57 | 70 | Chattanooga (78) | Final | L | -13 |
| 33 | 2022-03-05 | UNC-Greensboro (155) | 64 | 66 | Samford (144) | Final | W | 2 |
| 34 | 2022-03-06 | Samford (146) | 68 | 71 | Furman (98) | Final | L | -3 |