Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Texas Southern (171) | 66 | 83 | Oregon (28) | Final | L | -17 |
| 2 | 2021-11-12 | Texas Southern (317) | 58 | 67 | Saint Mary's (33) | Final | L | -9 |
| 3 | 2021-11-15 | Texas Southern (285) | 65 | 72 | Washington (211) | Final | L | -7 |
| 4 | 2021-11-17 | Texas Southern (317) | 57 | 61 | Air Force (347) | Final | L | -4 |
| 5 | 2021-11-21 | Texas Southern (324) | 57 | 65 | North Carolina State (96) | Final | L | -8 |
| 6 | 2021-11-24 | Texas Southern (317) | 64 | 81 | BYU (23) | Final | L | -17 |
| 7 | 2021-12-01 | Texas Southern (317) | 60 | 87 | Louisiana Tech (185) | Final | L | -27 |
| 8 | 2021-12-06 | Texas Southern (327) | 69 | 54 | Florida (24) | Final | W | 15 |
| 9 | 2021-12-14 | Texas Southern (317) | 70 | 60 | UTRGV (161) | Final | W | 10 |
| 10 | 2021-12-18 | Texas Southern | 0 | 0 | Cincinnati | Cancelled | - | - |
| 11 | 2021-12-29 | Texas Southern (317) | 0 | 0 | TCU (32) | Cancelled | - | - |
| 12 | 2022-01-03 | Texas Southern (317) | 50 | 63 | Southern (259) | Final | L | -13 |
| 13 | 2022-01-05 | Texas Southern (317) | 67 | 61 | Grambling (312) | Final | W | 6 |
| 14 | 2022-01-08 | Arkansas-Pine Bluff (303) | 71 | 90 | Texas Southern (317) | Final | W | 19 |
| 15 | 2022-01-10 | Mississippi Valley State (355) | 58 | 95 | Texas Southern (258) | Final | W | 37 |
| 16 | 2022-01-15 | Texas Southern (317) | 72 | 73 | Alcorn State (348) | Final | L | -1 |
| 17 | 2022-01-17 | Texas Southern (256) | 58 | 61 | Jackson State (305) | Final | L | -3 |
| 18 | 2022-01-22 | Alabama A&M (286) | 44 | 78 | Texas Southern (317) | Final | W | 34 |
| 19 | 2022-01-24 | Alabama State (331) | 66 | 73 | Texas Southern (317) | Final | W | 7 |
| 20 | 2022-01-29 | Texas Southern (317) | 75 | 74 | Prairie View A&M (285) | Final/OT | W | 1 |
| 21 | 2022-02-05 | Texas Southern (317) | 67 | 55 | Florida A&M (297) | Final | W | 12 |
| 22 | 2022-02-07 | Texas Southern (317) | 66 | 63 | Bethune-Cookman (240) | Final | W | 3 |
| 23 | 2022-02-12 | Grambling (312) | 65 | 68 | Texas Southern (317) | Final | W | 3 |
| 24 | 2022-02-14 | Southern (259) | 70 | 58 | Texas Southern (317) | Final | L | -12 |
| 25 | 2022-02-19 | Texas Southern (237) | 79 | 59 | Mississippi Valley State (357) | Final | W | 20 |
| 26 | 2022-02-21 | Texas Southern (238) | 70 | 68 | Arkansas-Pine Bluff (352) | Final | W | 2 |
| 27 | 2022-02-26 | Jackson State (311) | 66 | 81 | Texas Southern (238) | Final | W | 15 |
| 28 | 2022-02-28 | Alcorn State (272) | 75 | 72 | Texas Southern (230) | Final | L | -3 |
| 29 | 2022-03-05 | Prairie View A&M (306) | 77 | 78 | Texas Southern (230) | Final | W | 1 |
| 30 | 2022-03-09 | Jackson State (302) | 50 | 54 | Texas Southern (233) | Final | W | 4 |
| 31 | 2022-03-11 | Grambling (317) | 54 | 73 | Texas Southern (233) | Final | W | 19 |
| 32 | 2022-03-12 | Texas Southern (233) | 87 | 62 | Alcorn State (259) | Final | W | 25 |
| 33 | 2022-03-15 | Texas A&M-Corpus Christi (227) | 67 | 76 | Texas Southern (217) | Final | W | 9 |
| 34 | 2022-03-17 | Texas Southern (217) | 56 | 83 | Kansas (3) | Final | L | -27 |