Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | North Alabama (244) | 49 | 75 | Mississippi State (82) | Final | L | -26 |
| 2 | 2021-11-13 | North Alabama (244) | 99 | 47 | Virgin Islands | Final | W | 52 |
| 3 | 2021-11-19 | North Alabama (335) | 51 | 55 | Manhattan (307) | Final | L | -4 |
| 4 | 2021-11-20 | Iona (220) | 81 | 65 | North Alabama (335) | Final | L | -16 |
| 5 | 2021-11-23 | Oakwood | 50 | 105 | North Alabama (262) | Final | W | 55 |
| 6 | 2021-11-28 | North Alabama (204) | 81 | 69 | Alabama State (291) | Final | W | 12 |
| 7 | 2021-12-01 | Mississippi Valley State (365) | 58 | 72 | North Alabama (335) | Final | W | 14 |
| 8 | 2021-12-05 | Carver Bible | 40 | 103 | North Alabama (204) | Final | W | 63 |
| 9 | 2021-12-08 | Alabama A&M (315) | 45 | 56 | North Alabama (189) | Final | W | 11 |
| 10 | 2021-12-14 | North Alabama (335) | 44 | 70 | Auburn (37) | Final | L | -26 |
| 11 | 2021-12-18 | Southeast Baptist | 40 | 106 | North Alabama (335) | Final | W | 66 |
| 12 | 2021-12-22 | North Alabama (335) | 64 | 75 | Central Florida (43) | Final | L | -11 |
| 13 | 2021-12-28 | North Alabama (335) | 63 | 93 | Gonzaga (11) | Final | L | -30 |
| 14 | 2022-01-04 | North Alabama (335) | 74 | 84 | Lipscomb (190) | Final | L | -10 |
| 15 | 2022-01-08 | Jacksonville State (227) | 65 | 55 | North Alabama (335) | Final | L | -10 |
| 16 | 2022-01-11 | Eastern Kentucky (288) | 75 | 76 | North Alabama (335) | Final | W | 1 |
| 17 | 2022-01-15 | North Alabama (335) | 88 | 89 | Central Arkansas (143) | Final/OT | L | -1 |
| 18 | 2022-01-18 | North Alabama (335) | 60 | 68 | Bellarmine (266) | Final | L | -8 |
| 19 | 2022-01-22 | Stetson (301) | 67 | 65 | North Alabama (335) | Final | L | -2 |
| 20 | 2022-01-27 | North Alabama (335) | 53 | 72 | Liberty (93) | Final | L | -19 |
| 21 | 2022-01-29 | North Alabama (335) | 71 | 58 | Kennesaw State (142) | Final | W | 13 |
| 22 | 2022-02-03 | Jacksonville (281) | 56 | 50 | North Alabama (335) | Final | L | -6 |
| 23 | 2022-02-05 | North Florida (345) | 71 | 58 | North Alabama (335) | Final | L | -13 |
| 24 | 2022-02-09 | North Alabama (335) | 60 | 92 | Florida Gulf Coast (241) | Final | L | -32 |
| 25 | 2022-02-12 | Bellarmine (266) | 75 | 69 | North Alabama (335) | Final | L | -6 |
| 26 | 2022-02-16 | North Alabama (294) | 76 | 80 | Eastern Kentucky (275) | Final (OT) | L | -4 |
| 27 | 2022-02-19 | Lipscomb (282) | 75 | 72 | North Alabama (294) | Final | L | -3 |
| 28 | 2022-02-23 | Central Arkansas (285) | 81 | 72 | North Alabama (305) | Final | L | -9 |
| 29 | 2022-02-26 | North Alabama (305) | 52 | 69 | Jacksonville State (140) | Final | L | -17 |
| 30 | 2022-03-01 | North Alabama (312) | 72 | 81 | Florida Gulf Coast (163) | Final | L | -9 |