Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Southern (287) | 60 | 72 | Louisville (50) | Final | L | -12 |
| 2 | 2021-11-13 | Southern (287) | 73 | 70 | Tulane (155) | Final | W | 3 |
| 3 | 2021-11-16 | Southern (181) | 63 | 81 | Rice (155) | Final | L | -18 |
| 4 | 2021-11-19 | Southern (259) | 68 | 71 | South Dakota (275) | Final | L | -3 |
| 5 | 2021-11-21 | Southern (287) | 59 | 82 | Nebraska (145) | Final | L | -23 |
| 6 | 2021-11-23 | Ecclesia | 53 | 109 | Southern (287) | Final | W | 56 |
| 7 | 2021-11-28 | Southern (248) | 82 | 80 | Tennessee State (339) | Final | W | 2 |
| 8 | 2021-12-04 | Southern (259) | 62 | 79 | Akron (59) | Final | L | -17 |
| 9 | 2021-12-07 | Southern (259) | 64 | 76 | Kentucky (26) | Final | L | -12 |
| 10 | 2021-12-09 | Lindsey Wilson | 68 | 86 | Southern (274) | Final | W | 18 |
| 11 | 2021-12-11 | Southeastern Louisiana (318) | 66 | 72 | Southern (259) | Final | W | 6 |
| 12 | 2021-12-19 | Southern (259) | 78 | 76 | Kent State (107) | Final | W | 2 |
| 13 | 2021-12-21 | Southern (259) | 60 | 69 | Dayton (66) | Final | L | -9 |
| 14 | 2022-01-03 | Texas Southern (317) | 50 | 63 | Southern (259) | Final | W | 13 |
| 15 | 2022-01-05 | Prairie View A&M (285) | 0 | 2 | Southern (259) | Forfeit | W | 2 |
| 16 | 2022-01-08 | Southern (259) | 80 | 66 | Florida A&M (297) | Final | W | 14 |
| 17 | 2022-01-10 | Southern (212) | 69 | 59 | Bethune-Cookman (323) | Final | W | 10 |
| 18 | 2022-01-15 | Southern (259) | 77 | 83 | Grambling (312) | Final | L | -6 |
| 19 | 2022-01-22 | Arkansas-Pine Bluff (303) | 51 | 99 | Southern (259) | Final | W | 48 |
| 20 | 2022-01-24 | Mississippi Valley State (365) | 72 | 100 | Southern (259) | Final | W | 28 |
| 21 | 2022-01-29 | Southern (259) | 64 | 68 | Alcorn State (348) | Final | L | -4 |
| 22 | 2022-01-31 | Southern (217) | 75 | 64 | Jackson State (322) | Final | W | 11 |
| 23 | 2022-02-05 | Alabama A&M (286) | 64 | 73 | Southern (259) | Final | W | 9 |
| 24 | 2022-02-07 | Alabama State (331) | 58 | 72 | Southern (259) | Final | W | 14 |
| 25 | 2022-02-12 | Southern (259) | 77 | 84 | Prairie View A&M (285) | Final | L | -7 |
| 26 | 2022-02-14 | Southern (259) | 70 | 58 | Texas Southern (317) | Final | W | 12 |
| 27 | 2022-02-19 | Grambling (297) | 61 | 57 | Southern (220) | Final | L | -4 |
| 28 | 2022-02-26 | Bethune-Cookman (341) | 87 | 84 | Southern (225) | Final | L | -3 |
| 29 | 2022-02-28 | Florida A&M (309) | 51 | 58 | Southern (232) | Final | W | 7 |
| 30 | 2022-03-03 | Southern (232) | 67 | 77 | Alabama State (343) | Final | L | -10 |
| 31 | 2022-03-05 | Southern (232) | 50 | 49 | Alabama A&M (325) | Final | W | 1 |
| 32 | 2022-03-10 | Grambling (317) | 60 | 58 | Southern (232) | Final | L | -2 |