Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Prairie View A&M (168) | 68 | 87 | Saint Mary's (57) | Final | L | -19 |
| 2 | 2021-11-11 | Prairie View A&M (168) | 76 | 92 | San Francisco (124) | Final | L | -16 |
| 3 | 2021-11-13 | Prairie View A&M (168) | 49 | 77 | Michigan (4) | Final | L | -28 |
| 4 | 2021-11-14 | Prairie View A&M (285) | 59 | 72 | Oklahoma State (57) | Final | L | -13 |
| 5 | 2021-11-15 | Prairie View A&M (349) | 49 | 84 | Texas Tech (84) | Final | L | -35 |
| 6 | 2021-11-17 | Prairie View A&M (285) | 64 | 91 | Grand Canyon (74) | Final | L | -27 |
| 7 | 2021-11-27 | Prairie View A&M (339) | 80 | 83 | Loyola Marymount (215) | Final | L | -3 |
| 8 | 2021-11-30 | Prairie View A&M (326) | 90 | 99 | South Dakota State (82) | Final | L | -9 |
| 9 | 2021-12-10 | Prairie View A&M (325) | 60 | 97 | Boise State (107) | Final | L | -37 |
| 10 | 2021-12-22 | Prairie View A&M (285) | 66 | 102 | Wichita State (76) | Final | L | -36 |
| 11 | 2021-12-28 | Prairie View A&M (285) | 0 | 0 | Valparaiso (156) | Cancelled | - | - |
| 12 | 2021-12-30 | Prairie View A&M (285) | 0 | 0 | Northwestern (75) | Cancelled | - | - |
| 13 | 2022-01-03 | Prairie View A&M (285) | 0 | 2 | Grambling (312) | Forfeit | L | -2 |
| 14 | 2022-01-05 | Prairie View A&M (285) | 0 | 2 | Southern (259) | Forfeit | L | -2 |
| 15 | 2022-01-08 | Mississippi Valley State (365) | 84 | 82 | Prairie View A&M (285) | Final/OT | L | -2 |
| 16 | 2022-01-10 | Arkansas-Pine Bluff (347) | 58 | 75 | Prairie View A&M (351) | Final | W | 17 |
| 17 | 2022-01-15 | Prairie View A&M (285) | 64 | 75 | Jackson State (329) | Final | L | -11 |
| 18 | 2022-01-17 | Prairie View A&M (347) | 74 | 73 | Alcorn State (271) | Final | W | 1 |
| 19 | 2022-01-22 | Alabama State (331) | 67 | 70 | Prairie View A&M (285) | Final | W | 3 |
| 20 | 2022-01-24 | Alabama A&M (286) | 48 | 72 | Prairie View A&M (285) | Final | W | 24 |
| 21 | 2022-01-29 | Texas Southern (317) | 75 | 74 | Prairie View A&M (285) | Final/OT | L | -1 |
| 22 | 2022-02-05 | Prairie View A&M (285) | 67 | 68 | Bethune-Cookman (240) | Final | L | -1 |
| 23 | 2022-02-07 | Prairie View A&M (285) | 60 | 61 | Florida A&M (297) | Final | L | -1 |
| 24 | 2022-02-12 | Southern (259) | 77 | 84 | Prairie View A&M (285) | Final | W | 7 |
| 25 | 2022-02-14 | Grambling (312) | 70 | 71 | Prairie View A&M (285) | Final | W | 1 |
| 26 | 2022-02-19 | Prairie View A&M (319) | 92 | 84 | Arkansas-Pine Bluff (350) | Final | W | 8 |
| 27 | 2022-02-22 | Prairie View A&M (306) | 69 | 64 | Mississippi Valley State (356) | Final | W | 5 |
| 28 | 2022-02-26 | Alcorn State (272) | 72 | 69 | Prairie View A&M (306) | Final | L | -3 |
| 29 | 2022-02-28 | Jackson State (315) | 59 | 53 | Prairie View A&M (306) | Final | L | -6 |
| 30 | 2022-03-05 | Prairie View A&M (306) | 77 | 78 | Texas Southern (230) | Final | L | -1 |
| 31 | 2022-03-09 | Prairie View A&M (313) | 63 | 64 | Alcorn State (259) | Final | L | -1 |