Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Southeast Missouri State (276) | 99 | 94 | Missouri State (94) | Final | L | -5 |
| 2 | 2021-11-13 | Alabama State (340) | 60 | 78 | Missouri State (94) | Final | W | 18 |
| 3 | 2021-11-17 | Missouri State (224) | 77 | 55 | Sam Houston State (120) | Final | W | 22 |
| 4 | 2021-11-22 | Long Beach State (278) | 66 | 92 | Missouri State (224) | Final | W | 26 |
| 5 | 2021-11-23 | Missouri State (140) | 76 | 77 | East Tennessee State (234) | Final | L | -1 |
| 6 | 2021-11-24 | Missouri State (224) | 72 | 54 | George Washington (104) | Final | W | 18 |
| 7 | 2021-12-01 | Missouri State (224) | 74 | 79 | Illinois State (94) | Final/OT | L | -5 |
| 8 | 2021-12-04 | BYU (23) | 74 | 68 | Missouri State (224) | Final | L | -6 |
| 9 | 2021-12-08 | Missouri State (198) | 81 | 55 | Little Rock (255) | Final | W | 26 |
| 10 | 2021-12-11 | Oral Roberts (327) | 60 | 69 | Missouri State (224) | Final | W | 9 |
| 11 | 2021-12-15 | South Dakota State (268) | 63 | 75 | Missouri State (224) | Final | W | 12 |
| 12 | 2021-12-18 | Central Arkansas (143) | 70 | 106 | Missouri State (224) | Final | W | 36 |
| 13 | 2021-12-22 | Missouri State (224) | 58 | 75 | Saint Mary's (33) | Final | L | -17 |
| 14 | 2021-12-30 | Evangel | 56 | 103 | Missouri State (224) | Final | W | 47 |
| 15 | 2022-01-02 | Drake (217) | 56 | 61 | Missouri State (224) | Final | W | 5 |
| 16 | 2022-01-05 | Missouri State (224) | 71 | 69 | Bradley (113) | Final | W | 2 |
| 17 | 2022-01-08 | Northern Iowa (89) | 85 | 84 | Missouri State (224) | Final | L | -1 |
| 18 | 2022-01-12 | Southern Illinois (167) | 76 | 81 | Missouri State (116) | Final | W | 5 |
| 19 | 2022-01-15 | Missouri State (224) | 74 | 57 | Valparaiso (156) | Final | W | 17 |
| 20 | 2022-01-19 | Illinois State (94) | 63 | 88 | Missouri State (224) | Final | W | 25 |
| 21 | 2022-01-22 | Missouri State (224) | 79 | 69 | Loyola-Chicago (263) | Final | W | 10 |
| 22 | 2022-01-25 | Missouri State (75) | 72 | 76 | Indiana State (232) | Final | L | -4 |
| 23 | 2022-01-29 | Evansville (302) | 58 | 72 | Missouri State (224) | Final | W | 14 |
| 24 | 2022-02-02 | Missouri State (92) | 69 | 54 | Southern Illinois (187) | Final | W | 15 |
| 25 | 2022-02-06 | Loyola-Chicago (263) | 71 | 62 | Missouri State (224) | Final | L | -9 |
| 26 | 2022-02-09 | Missouri State (224) | 66 | 62 | Drake (217) | Final | W | 4 |
| 27 | 2022-02-12 | Valparaiso (156) | 66 | 84 | Missouri State (224) | Final | W | 18 |
| 28 | 2022-02-15 | Indiana State (242) | 70 | 79 | Missouri State (91) | Final | W | 9 |
| 29 | 2022-02-20 | Missouri State (98) | 75 | 95 | Northern Iowa (113) | Final | L | -20 |
| 30 | 2022-02-23 | Bradley (129) | 67 | 83 | Missouri State (98) | Final | W | 16 |
| 31 | 2022-02-26 | Missouri State (98) | 88 | 79 | Evansville (318) | Final | W | 9 |
| 32 | 2022-03-04 | Valparaiso (212) | 58 | 67 | Missouri State (91) | Final | W | 9 |
| 33 | 2022-03-05 | Drake (92) | 79 | 78 | Missouri State (91) | Final | L | -1 |
| 34 | 2022-03-15 | Missouri State (92) | 72 | 89 | Oklahoma (44) | Final | L | -17 |