Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Arkansas-Pine Bluff (341) | 77 | 90 | Creighton (25) | Final | L | -13 |
| 2 | 2021-11-12 | Arkansas-Pine Bluff (303) | 71 | 91 | Colorado State (85) | Final | L | -20 |
| 3 | 2021-11-14 | Arkansas-Pine Bluff (303) | 45 | 85 | Wyoming (103) | Final | L | -40 |
| 4 | 2021-11-18 | Arkansas-Pine Bluff (336) | 74 | 86 | Portland (217) | Final | L | -12 |
| 5 | 2021-11-22 | Arkansas-Pine Bluff (303) | 56 | 77 | Seattle (118) | Final | L | -21 |
| 6 | 2021-11-24 | Arkansas-Pine Bluff (303) | 58 | 86 | UC-Santa Barbara (171) | Final | L | -28 |
| 7 | 2021-11-26 | Arkansas-Pine Bluff (303) | 50 | 74 | Pacific (132) | Final | L | -24 |
| 8 | 2021-11-29 | Arkansas Baptist | 70 | 75 | Arkansas-Pine Bluff (350) | Final | W | 5 |
| 9 | 2021-12-01 | Arkansas-Pine Bluff (303) | 64 | 83 | Iowa State (7) | Final | L | -19 |
| 10 | 2021-12-04 | Arkansas-Pine Bluff (303) | 54 | 99 | Baylor (58) | Final | L | -45 |
| 11 | 2021-12-08 | Arkansas State (218) | 84 | 73 | Arkansas-Pine Bluff (345) | Final | L | -11 |
| 12 | 2021-12-14 | Arkansas-Pine Bluff (303) | 31 | 63 | Texas (41) | Final | L | -32 |
| 13 | 2021-12-18 | Ecclesia | 56 | 97 | Arkansas-Pine Bluff (303) | Final | W | 41 |
| 14 | 2022-01-03 | Alabama A&M (286) | 70 | 50 | Arkansas-Pine Bluff (303) | Final | L | -20 |
| 15 | 2022-01-05 | Alabama State (331) | 68 | 70 | Arkansas-Pine Bluff (303) | Final | W | 2 |
| 16 | 2022-01-08 | Arkansas-Pine Bluff (303) | 71 | 90 | Texas Southern (317) | Final | L | -19 |
| 17 | 2022-01-10 | Arkansas-Pine Bluff (347) | 58 | 75 | Prairie View A&M (351) | Final | L | -17 |
| 18 | 2022-01-15 | Florida A&M (297) | 71 | 66 | Arkansas-Pine Bluff (303) | Final/OT | L | -5 |
| 19 | 2022-01-17 | Bethune-Cookman (322) | 63 | 69 | Arkansas-Pine Bluff (352) | Final | W | 6 |
| 20 | 2022-01-22 | Arkansas-Pine Bluff (303) | 51 | 99 | Southern (259) | Final | L | -48 |
| 21 | 2022-01-24 | Arkansas-Pine Bluff (303) | 65 | 76 | Grambling (312) | Final | L | -11 |
| 22 | 2022-01-29 | Arkansas-Pine Bluff (303) | 74 | 68 | Mississippi Valley State (365) | Final | W | 6 |
| 23 | 2022-02-05 | Alcorn State (348) | 70 | 64 | Arkansas-Pine Bluff (303) | Final | L | -6 |
| 24 | 2022-02-07 | Jackson State (329) | 60 | 47 | Arkansas-Pine Bluff (303) | Final | L | -13 |
| 25 | 2022-02-12 | Arkansas-Pine Bluff (303) | 75 | 70 | Alabama State (331) | Final | W | 5 |
| 26 | 2022-02-14 | Arkansas-Pine Bluff (303) | 69 | 74 | Alabama A&M (286) | Final | L | -5 |
| 27 | 2022-02-19 | Prairie View A&M (319) | 92 | 84 | Arkansas-Pine Bluff (350) | Final | L | -8 |
| 28 | 2022-02-21 | Texas Southern (238) | 70 | 68 | Arkansas-Pine Bluff (352) | Final | L | -2 |
| 29 | 2022-02-26 | Mississippi Valley State (356) | 79 | 93 | Arkansas-Pine Bluff (352) | Final | W | 14 |
| 30 | 2022-03-03 | Arkansas-Pine Bluff (351) | 79 | 87 | Jackson State (315) | Final | L | -8 |
| 31 | 2022-03-05 | Arkansas-Pine Bluff (351) | 77 | 100 | Alcorn State (272) | Final | L | -23 |