Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Montevallo | 63 | 67 | DePaul (177) | Final | W | 4 |
| 2 | 2021-11-10 | Coppin State (273) | 72 | 97 | DePaul (177) | Final | W | 25 |
| 3 | 2021-11-13 | Central Michigan (298) | 66 | 99 | DePaul (177) | Final | W | 33 |
| 4 | 2021-11-18 | Rutgers (68) | 70 | 73 | DePaul (89) | Final | W | 3 |
| 5 | 2021-11-20 | Western Illinois (362) | 80 | 84 | DePaul (95) | Final | W | 4 |
| 6 | 2021-11-26 | Northern Kentucky (195) | 68 | 77 | DePaul (95) | Final | W | 9 |
| 7 | 2021-11-28 | Eastern Michigan (199) | 63 | 101 | DePaul (22) | Final | W | 38 |
| 8 | 2021-12-04 | Loyola-Chicago (263) | 68 | 64 | DePaul (95) | Final | L | -4 |
| 9 | 2021-12-07 | Duquesne (121) | 67 | 87 | DePaul (95) | Final | W | 20 |
| 10 | 2021-12-10 | DePaul (54) | 62 | 55 | Louisville (48) | Final | W | 7 |
| 11 | 2021-12-14 | DePaul (95) | 72 | 66 | Illinois-Chicago (139) | Final | W | 6 |
| 12 | 2021-12-18 | DePaul (95) | 0 | 0 | Northwestern (75) | Cancelled | - | - |
| 13 | 2021-12-23 | Seton Hall (53) | 0 | 0 | DePaul (95) | Postponed | - | - |
| 14 | 2021-12-29 | DePaul (95) | 59 | 63 | Butler (80) | Final | L | -4 |
| 15 | 2022-01-01 | Providence (82) | 70 | 53 | DePaul (95) | Final | L | -17 |
| 16 | 2022-01-05 | DePaul (95) | 84 | 89 | St. John's (12) | Final | L | -5 |
| 17 | 2022-01-08 | Villanova (29) | 79 | 64 | DePaul (95) | Final | L | -15 |
| 18 | 2022-01-11 | DePaul (95) | 76 | 87 | Marquette (106) | Final | L | -11 |
| 19 | 2022-01-13 | Seton Hall (53) | 92 | 96 | DePaul (95) | Final | W | 4 |
| 20 | 2022-01-19 | Xavier (92) | 68 | 67 | DePaul (95) | Final | L | -1 |
| 21 | 2022-01-22 | DePaul (95) | 47 | 60 | Creighton (78) | Final | L | -13 |
| 22 | 2022-01-25 | DePaul (91) | 43 | 67 | Villanova (15) | Final | L | -24 |
| 23 | 2022-01-29 | Connecticut (4) | 57 | 50 | DePaul (95) | Final | L | -7 |
| 24 | 2022-02-05 | DePaul (95) | 69 | 65 | Xavier (92) | Final | W | 4 |
| 25 | 2022-02-09 | Georgetown (83) | 74 | 82 | DePaul (95) | Final | W | 8 |
| 26 | 2022-02-12 | DePaul (95) | 73 | 76 | Providence (82) | Final/OT | L | -3 |
| 27 | 2022-02-15 | Butler (108) | 73 | 71 | DePaul (88) | Final | L | -2 |
| 28 | 2022-02-17 | Creighton (78) | 71 | 59 | DePaul (95) | Final | L | -12 |
| 29 | 2022-02-19 | DePaul (88) | 64 | 66 | Seton Hall (32) | Final | L | -2 |
| 30 | 2022-02-24 | DePaul (102) | 68 | 65 | Georgetown (201) | Final | W | 3 |
| 31 | 2022-02-27 | St. John's (73) | 94 | 99 | DePaul (93) | Final | W | 5 |
| 32 | 2022-03-02 | Marquette (30) | 80 | 91 | DePaul (93) | Final | W | 11 |
| 33 | 2022-03-05 | DePaul (93) | 68 | 75 | Connecticut (16) | Final | L | -7 |
| 34 | 2022-03-09 | DePaul (84) | 73 | 92 | St. John's (71) | Final | L | -19 |