Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Misericordia | 48 | 110 | Seton Hall (66) | Final | W | 62 |
| 2 | 2021-11-10 | Fairleigh Dickinson (253) | 49 | 93 | Seton Hall (66) | Final | W | 44 |
| 3 | 2021-11-14 | Yale (81) | 44 | 80 | Seton Hall (53) | Final | W | 36 |
| 4 | 2021-11-16 | Seton Hall (2) | 67 | 65 | Michigan (72) | Final | W | 2 |
| 5 | 2021-11-22 | Seton Hall (53) | 76 | 79 | Ohio State (34) | Final | L | -3 |
| 6 | 2021-11-24 | Seton Hall (53) | 62 | 59 | California (65) | Final | W | 3 |
| 7 | 2021-11-28 | Bethune-Cookman (296) | 70 | 84 | Seton Hall (43) | Final | W | 14 |
| 8 | 2021-12-01 | Wagner (316) | 63 | 85 | Seton Hall (53) | Final | W | 22 |
| 9 | 2021-12-04 | Nyack | 67 | 113 | Seton Hall (43) | Final | W | 46 |
| 10 | 2021-12-09 | Texas (31) | 60 | 64 | Seton Hall (32) | Final | W | 4 |
| 11 | 2021-12-12 | Rutgers (112) | 63 | 77 | Seton Hall (53) | Final | W | 14 |
| 12 | 2021-12-18 | Iona (220) | 0 | 0 | Seton Hall (53) | Cancelled | - | - |
| 13 | 2021-12-20 | St. John's (12) | 0 | 0 | Seton Hall (53) | Postponed | - | - |
| 14 | 2021-12-23 | Seton Hall (53) | 0 | 0 | DePaul (95) | Postponed | - | - |
| 15 | 2021-12-29 | Seton Hall (53) | 65 | 70 | Providence (82) | Final | L | -5 |
| 16 | 2022-01-01 | Villanova (29) | 73 | 67 | Seton Hall (53) | Final | L | -6 |
| 17 | 2022-01-04 | Seton Hall (53) | 71 | 56 | Butler (80) | Final | W | 15 |
| 18 | 2022-01-08 | Connecticut (4) | 87 | 90 | Seton Hall (53) | Final/OT | W | 3 |
| 19 | 2022-01-13 | Seton Hall (53) | 92 | 96 | DePaul (95) | Final | L | -4 |
| 20 | 2022-01-15 | Seton Hall (53) | 72 | 73 | Marquette (106) | Final | L | -1 |
| 21 | 2022-01-18 | Providence (82) | 0 | 0 | Seton Hall (53) | Canceled | - | - |
| 22 | 2022-01-22 | Seton Hall (53) | 66 | 60 | St. John's (12) | Final | W | 6 |
| 23 | 2022-01-24 | St. John's (12) | 84 | 63 | Seton Hall (53) | Final | L | -21 |
| 24 | 2022-01-26 | Marquette (24) | 73 | 63 | Seton Hall (30) | Final | L | -10 |
| 25 | 2022-02-01 | Seton Hall (44) | 70 | 63 | Georgetown (185) | Final | W | 7 |
| 26 | 2022-02-04 | Creighton (60) | 55 | 74 | Seton Hall (44) | Final | W | 19 |
| 27 | 2022-02-09 | Xavier (92) | 71 | 73 | Seton Hall (53) | Final | W | 2 |
| 28 | 2022-02-12 | Seton Hall (53) | 67 | 73 | Villanova (29) | Final | L | -6 |
| 29 | 2022-02-16 | Seton Hall (32) | 65 | 70 | Connecticut (24) | Final | L | -5 |
| 30 | 2022-02-19 | DePaul (88) | 64 | 66 | Seton Hall (32) | Final | W | 2 |
| 31 | 2022-02-23 | Butler (112) | 60 | 66 | Seton Hall (33) | Final | W | 6 |
| 32 | 2022-02-26 | Seton Hall (33) | 82 | 66 | Xavier (29) | Final | W | 16 |
| 33 | 2022-03-02 | Georgetown (205) | 68 | 73 | Seton Hall (31) | Final | W | 5 |
| 34 | 2022-03-05 | Seton Hall (31) | 65 | 60 | Creighton (42) | Final | W | 5 |
| 35 | 2022-03-09 | Georgetown (205) | 53 | 57 | Seton Hall (27) | Final | W | 4 |
| 36 | 2022-03-10 | Seton Hall (27) | 52 | 62 | Connecticut (18) | Final | L | -10 |
| 37 | 2022-03-18 | TCU (35) | 69 | 42 | Seton Hall (29) | Final | L | -27 |