Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Evansville (225) | 43 | 65 | Cincinnati (97) | Final | W | 22 |
| 2 | 2021-11-13 | Georgia (92) | 68 | 73 | Cincinnati (97) | Final | W | 5 |
| 3 | 2021-11-16 | Alabama A&M (219) | 66 | 89 | Cincinnati (33) | Final | W | 23 |
| 4 | 2021-11-18 | Presbyterian (156) | 45 | 79 | Cincinnati (33) | Final | W | 34 |
| 5 | 2021-11-22 | Illinois (9) | 51 | 71 | Cincinnati (54) | Final | W | 20 |
| 6 | 2021-11-23 | Cincinnati (26) | 67 | 73 | Arkansas (75) | Final | L | -6 |
| 7 | 2021-11-27 | Monmouth (93) | 61 | 59 | Cincinnati (26) | Final | L | -2 |
| 8 | 2021-12-01 | Cincinnati (54) | 59 | 58 | Miami (OH) (40) | Final | W | 1 |
| 9 | 2021-12-05 | Bryant (214) | 58 | 73 | Cincinnati (57) | Final | W | 15 |
| 10 | 2021-12-11 | Cincinnati (54) | 63 | 83 | Xavier (92) | Final | L | -20 |
| 11 | 2021-12-14 | Florida A&M (297) | 50 | 77 | Cincinnati (54) | Final | W | 27 |
| 12 | 2021-12-18 | Ashland | 57 | 71 | Cincinnati (54) | Final | W | 14 |
| 13 | 2021-12-18 | Texas Southern | 0 | 0 | Cincinnati | Cancelled | - | - |
| 14 | 2021-12-21 | Tennessee Tech (310) | 67 | 76 | Cincinnati (54) | Final | W | 9 |
| 15 | 2021-12-21 | Tennessee Tech (313) | 75 | 86 | Cincinnati (64) | Final | W | 11 |
| 16 | 2021-12-28 | Cincinnati (54) | 0 | 0 | Houston (5) | Postponed | - | - |
| 17 | 2022-01-01 | Tulane (167) | 68 | 60 | Cincinnati (54) | Final | L | -8 |
| 18 | 2022-01-06 | SMU (45) | 60 | 77 | Cincinnati (54) | Final | W | 17 |
| 19 | 2022-01-09 | Cincinnati (90) | 80 | 87 | Memphis (54) | Final | L | -7 |
| 20 | 2022-01-12 | East Carolina (114) | 71 | 79 | Cincinnati (90) | Final | W | 8 |
| 21 | 2022-01-16 | Cincinnati (70) | 61 | 57 | Wichita State (96) | Final | W | 4 |
| 22 | 2022-01-20 | Tulsa (55) | 69 | 90 | Cincinnati (54) | Final | W | 21 |
| 23 | 2022-01-25 | Cincinnati (71) | 58 | 61 | Temple (98) | Final | L | -3 |
| 24 | 2022-01-30 | Cincinnati (73) | 60 | 59 | East Carolina (131) | Final | W | 1 |
| 25 | 2022-02-03 | Memphis (136) | 0 | 0 | Cincinnati (54) | Postponed | - | - |
| 26 | 2022-02-06 | Houston (5) | 80 | 58 | Cincinnati (54) | Final | L | -22 |
| 27 | 2022-02-06 | Houston (5) | 83 | 59 | Cincinnati (80) | Final | L | -24 |
| 28 | 2022-02-09 | Cincinnati (54) | 70 | 59 | South Florida (52) | Final | W | 11 |
| 29 | 2022-02-12 | Cincinnati (54) | 77 | 83 | Tulsa (55) | Final | L | -6 |
| 30 | 2022-02-15 | Memphis (55) | 81 | 74 | Cincinnati (90) | Final | L | -7 |
| 31 | 2022-02-17 | Wichita State (76) | 76 | 85 | Cincinnati (54) | Final | W | 9 |
| 32 | 2022-02-20 | Temple (97) | 75 | 71 | Cincinnati (95) | Final | L | -4 |
| 33 | 2022-02-23 | Cincinnati (95) | 61 | 75 | Central Florida (81) | Final | L | -14 |
| 34 | 2022-02-26 | South Florida (245) | 56 | 54 | Cincinnati (95) | Final | L | -2 |
| 35 | 2022-03-03 | Cincinnati (110) | 71 | 76 | SMU (48) | Final | L | -5 |
| 36 | 2022-03-10 | East Carolina (142) | 63 | 74 | Cincinnati (110) | Final | W | 11 |
| 37 | 2022-03-11 | Cincinnati (110) | 56 | 69 | Houston (12) | Final | L | -13 |