Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Ball State (191) | 71 | 82 | Georgia Southern (216) | Final | L | -11 |
| 2 | 2021-11-13 | Nebraska-Omaha (334) | 69 | 73 | Ball State (191) | Final | W | 4 |
| 3 | 2021-11-18 | Ball State (174) | 60 | 73 | Florida International (223) | Final | L | -13 |
| 4 | 2021-11-19 | Weber State (235) | 85 | 74 | Ball State (298) | Final | L | -11 |
| 5 | 2021-11-21 | Ball State (214) | 89 | 86 | Massachusetts (162) | Final | W | 3 |
| 6 | 2021-11-27 | Indiana State (171) | 75 | 97 | Ball State (214) | Final | W | 22 |
| 7 | 2021-12-01 | Ball State (298) | 80 | 93 | Western Illinois (362) | Final | L | -13 |
| 8 | 2021-12-08 | Ball State (185) | 50 | 96 | Xavier (12) | Final | L | -46 |
| 9 | 2021-12-12 | Indiana-Kokomo | 58 | 85 | Ball State (225) | Final | W | 27 |
| 10 | 2021-12-18 | Ball State (298) | 64 | 85 | Illinois State (94) | Final | L | -21 |
| 11 | 2021-12-21 | Eastern Illinois (314) | 55 | 75 | Ball State (298) | Final | W | 20 |
| 12 | 2021-12-29 | Ball State (298) | 0 | 0 | Northern Illinois (326) | Postponed | - | - |
| 13 | 2022-01-01 | Bowling Green (168) | 80 | 81 | Ball State (298) | Final | W | 1 |
| 14 | 2022-01-04 | Kent State (107) | 66 | 65 | Ball State (298) | Final | L | -1 |
| 15 | 2022-01-08 | Ball State (298) | 78 | 72 | Eastern Michigan (277) | Final | W | 6 |
| 16 | 2022-01-11 | Ball State (298) | 74 | 84 | Akron (59) | Final | L | -10 |
| 17 | 2022-01-14 | Buffalo (156) | 74 | 68 | Ball State (246) | Final | L | -6 |
| 18 | 2022-01-18 | Ball State (298) | 70 | 83 | Toledo (135) | Final | L | -13 |
| 19 | 2022-01-22 | Ball State (298) | 0 | 0 | Central Michigan (311) | Canceled | - | - |
| 20 | 2022-01-25 | Miami (OH) (212) | 64 | 81 | Ball State (269) | Final | W | 17 |
| 21 | 2022-01-27 | Ball State (298) | 74 | 67 | Northern Illinois (326) | Final | W | 7 |
| 22 | 2022-01-29 | Western Michigan (304) | 72 | 83 | Ball State (298) | Final | W | 11 |
| 23 | 2022-02-01 | Ball State (236) | 63 | 87 | Ohio (53) | Final | L | -24 |
| 24 | 2022-02-04 | Toledo (58) | 83 | 93 | Ball State (236) | Final | W | 10 |
| 25 | 2022-02-08 | Central Michigan (313) | 89 | 85 | Ball State (223) | Final (OT) | L | -4 |
| 26 | 2022-02-12 | Ball State (298) | 74 | 80 | Buffalo (219) | Final | L | -6 |
| 27 | 2022-02-15 | Northern Illinois (300) | 64 | 58 | Ball State (245) | Final | L | -6 |
| 28 | 2022-02-19 | Ball State (245) | 91 | 82 | Bowling Green (241) | Final | W | 9 |
| 29 | 2022-02-22 | Ball State (249) | 82 | 93 | Kent State (119) | Final | L | -11 |
| 30 | 2022-02-26 | Eastern Michigan (280) | 64 | 75 | Ball State (249) | Final | W | 11 |
| 31 | 2022-03-01 | Akron (138) | 79 | 60 | Ball State (252) | Final | L | -19 |
| 32 | 2022-03-04 | Ball State (252) | 64 | 63 | Western Michigan (335) | Final | W | 1 |
| 33 | 2022-03-10 | Ball State (252) | 67 | 77 | Ohio (106) | Final | L | -10 |