Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-03 | Grand Valley State | 67 | 78 | Central Michigan (298) | Final | W | 11 |
| 2 | 2021-11-05 | Olivet | 0 | 0 | Central Michigan (298) | Cancelled | - | - |
| 3 | 2021-11-09 | Central Michigan (298) | 68 | 78 | Missouri (34) | Final | L | -10 |
| 4 | 2021-11-13 | Central Michigan (298) | 66 | 99 | DePaul (177) | Final | L | -33 |
| 5 | 2021-11-15 | Central Michigan (329) | 62 | 61 | Eastern Illinois (304) | Final | W | 1 |
| 6 | 2021-11-22 | Gonzaga (11) | 107 | 54 | Central Michigan (311) | Final | L | -53 |
| 7 | 2021-11-23 | Central Michigan (245) | 69 | 76 | Bellarmine (310) | Final | L | -7 |
| 8 | 2021-11-29 | Central Michigan (325) | 57 | 85 | Kentucky (27) | Final | L | -28 |
| 9 | 2021-12-01 | Central Michigan (311) | 45 | 78 | Xavier (92) | Final | L | -33 |
| 10 | 2021-12-05 | Western Illinois (120) | 97 | 70 | Central Michigan (325) | Final | L | -27 |
| 11 | 2021-12-08 | Central Michigan (338) | 77 | 84 | Youngstown State (219) | Final | L | -7 |
| 12 | 2021-12-11 | Illinois-Chicago (139) | 71 | 67 | Central Michigan (311) | Final | L | -4 |
| 13 | 2021-12-19 | Central Michigan (311) | 75 | 89 | Detroit (212) | Final | L | -14 |
| 14 | 2021-12-29 | Central Michigan (311) | 72 | 69 | Kent State (107) | Final | W | 3 |
| 15 | 2022-01-01 | Central Michigan (311) | 0 | 0 | Miami (OH) (40) | Postponed | - | - |
| 16 | 2022-01-04 | Toledo (135) | 82 | 54 | Central Michigan (311) | Final | L | -28 |
| 17 | 2022-01-08 | Western Michigan (304) | 0 | 0 | Central Michigan (311) | Postponed | - | - |
| 18 | 2022-01-11 | Central Michigan (311) | 68 | 99 | Eastern Michigan (277) | Final | L | -31 |
| 19 | 2022-01-15 | Ohio (218) | 0 | 0 | Central Michigan (311) | Postponed | - | - |
| 20 | 2022-01-18 | Central Michigan (311) | 0 | 0 | Buffalo (219) | Canceled | - | - |
| 21 | 2022-01-20 | Western Michigan (304) | 0 | 0 | Central Michigan (311) | Postponed | - | - |
| 22 | 2022-01-22 | Ball State (298) | 0 | 0 | Central Michigan (311) | Canceled | - | - |
| 23 | 2022-01-25 | Akron (125) | 60 | 56 | Central Michigan (340) | Final | L | -4 |
| 24 | 2022-01-29 | Central Michigan (311) | 69 | 63 | Northern Illinois (326) | Final | W | 6 |
| 25 | 2022-02-01 | Bowling Green (205) | 74 | 78 | Central Michigan (329) | Final | W | 4 |
| 26 | 2022-02-03 | Western Michigan (304) | 55 | 65 | Central Michigan (311) | Final | W | 10 |
| 27 | 2022-02-05 | Buffalo (219) | 74 | 54 | Central Michigan (311) | Final | L | -20 |
| 28 | 2022-02-08 | Central Michigan (313) | 89 | 85 | Ball State (223) | Final (OT) | W | 4 |
| 29 | 2022-02-10 | Ohio (218) | 81 | 72 | Central Michigan (311) | Final | L | -9 |
| 30 | 2022-02-12 | Central Michigan (311) | 63 | 77 | Western Michigan (304) | Final | L | -14 |
| 31 | 2022-02-15 | Eastern Michigan (277) | 75 | 70 | Central Michigan (308) | Final | L | -5 |
| 32 | 2022-02-19 | Central Michigan (308) | 66 | 68 | Toledo (63) | Final | L | -2 |
| 33 | 2022-02-22 | Central Michigan (312) | 50 | 76 | Ohio (77) | Final | L | -26 |
| 34 | 2022-02-24 | Central Michigan (312) | 83 | 69 | Miami (OH) (251) | Final | W | 14 |
| 35 | 2022-02-26 | Kent State (119) | 73 | 71 | Central Michigan (312) | Final | L | -2 |
| 36 | 2022-03-01 | Miami (OH) (274) | 75 | 61 | Central Michigan (305) | Final | L | -14 |
| 37 | 2022-03-04 | Central Michigan (305) | 56 | 57 | Akron (138) | Final | L | -1 |
| 38 | 2022-03-10 | Central Michigan (310) | 71 | 72 | Toledo (69) | Final | L | -1 |