Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-30 | Upper Iowa | 61 | 76 | Creighton (25) | Final | W | 15 |
| 2 | 2021-11-09 | Arkansas-Pine Bluff (341) | 77 | 90 | Creighton (25) | Final | W | 13 |
| 3 | 2021-11-11 | Kennesaw State (327) | 44 | 51 | Creighton (25) | Final | W | 7 |
| 4 | 2021-11-16 | Creighton (97) | 77 | 69 | Nebraska (165) | Final | W | 8 |
| 5 | 2021-11-19 | Brown (295) | 57 | 78 | Creighton (78) | Final | W | 21 |
| 6 | 2021-11-21 | Colorado State (40) | 95 | 81 | Creighton (78) | Final | L | -14 |
| 7 | 2021-11-22 | Creighton (78) | 66 | 64 | Southern Illinois (150) | Final | W | 2 |
| 8 | 2021-11-27 | SIU-Edwardsville (289) | 65 | 70 | Creighton (78) | Final | W | 5 |
| 9 | 2021-11-30 | North Dakota State (187) | 55 | 80 | Creighton (66) | Final | W | 25 |
| 10 | 2021-12-04 | Iowa State (7) | 64 | 58 | Creighton (78) | Final | L | -6 |
| 11 | 2021-12-11 | BYU (23) | 71 | 83 | Creighton (78) | Final | W | 12 |
| 12 | 2021-12-14 | Arizona State (61) | 58 | 57 | Creighton (78) | Final | L | -1 |
| 13 | 2021-12-17 | Villanova (29) | 59 | 79 | Creighton (78) | Final | W | 20 |
| 14 | 2021-12-28 | Georgetown (83) | 0 | 0 | Creighton (78) | Postponed | - | - |
| 15 | 2022-01-01 | Creighton (78) | 75 | 69 | Marquette (106) | Final/2OT | W | 6 |
| 16 | 2022-01-05 | Creighton (78) | 41 | 75 | Villanova (29) | Final | L | -34 |
| 17 | 2022-01-11 | Providence (82) | 0 | 0 | Creighton (78) | Canceled | - | - |
| 18 | 2022-01-15 | Creighton (78) | 73 | 80 | Xavier (92) | Final | L | -7 |
| 19 | 2022-01-19 | St. John's (12) | 64 | 87 | Creighton (78) | Final | W | 23 |
| 20 | 2022-01-22 | DePaul (95) | 47 | 60 | Creighton (78) | Final | W | 13 |
| 21 | 2022-01-26 | Creighton (44) | 55 | 72 | Butler (123) | Final | L | -17 |
| 22 | 2022-01-29 | Xavier (92) | 74 | 64 | Creighton (78) | Final | L | -10 |
| 23 | 2022-02-01 | Creighton (60) | 59 | 55 | Connecticut (17) | Final | W | 4 |
| 24 | 2022-02-04 | Creighton (60) | 55 | 74 | Seton Hall (44) | Final | L | -19 |
| 25 | 2022-02-08 | Butler (114) | 52 | 54 | Creighton (59) | Final | W | 2 |
| 26 | 2022-02-12 | Creighton (78) | 80 | 66 | Georgetown (83) | Final | W | 14 |
| 27 | 2022-02-14 | Georgetown (83) | 77 | 88 | Creighton (78) | Final | W | 11 |
| 28 | 2022-02-17 | Creighton (78) | 71 | 59 | DePaul (95) | Final | W | 12 |
| 29 | 2022-02-20 | Marquette (30) | 82 | 83 | Creighton (41) | Final | W | 1 |
| 30 | 2022-02-23 | Creighton (41) | 81 | 78 | St. John's (60) | Final | W | 3 |
| 31 | 2022-02-26 | Creighton (41) | 51 | 72 | Providence (11) | Final | L | -21 |
| 32 | 2022-03-02 | Connecticut (16) | 62 | 64 | Creighton (42) | Final | W | 2 |
| 33 | 2022-03-05 | Seton Hall (31) | 65 | 60 | Creighton (42) | Final | L | -5 |
| 34 | 2022-03-10 | Marquette (32) | 63 | 74 | Creighton (40) | Final | W | 11 |
| 35 | 2022-03-11 | Creighton (40) | 85 | 58 | Providence (10) | Final | W | 27 |
| 36 | 2022-03-12 | Creighton (40) | 48 | 54 | Villanova (8) | Final | L | -6 |
| 37 | 2022-03-17 | Creighton (32) | 72 | 69 | San Diego State (27) | Final (OT) | W | 3 |
| 38 | 2022-03-19 | Creighton (32) | 72 | 79 | Kansas (3) | Final | L | -7 |