Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Mississippi Valley State (347) | 61 | 119 | St. John's (67) | Final | W | 58 |
| 2 | 2021-11-13 | Saint Peter's (187) | 70 | 91 | St. John's (67) | Final | W | 21 |
| 3 | 2021-11-17 | St. John's (12) | 74 | 76 | Indiana (46) | Final | L | -2 |
| 4 | 2021-11-20 | Fairleigh Dickinson (343) | 74 | 87 | St. John's (12) | Final | W | 13 |
| 5 | 2021-11-23 | St. Francis (NY) (344) | 70 | 76 | St. John's (79) | Final | W | 6 |
| 6 | 2021-11-27 | NJIT (266) | 68 | 77 | St. John's (79) | Final (OT) | W | 9 |
| 7 | 2021-12-03 | Kansas (19) | 95 | 75 | St. John's (12) | Final | L | -20 |
| 8 | 2021-12-05 | Fordham (163) | 69 | 83 | St. John's (79) | Final | W | 14 |
| 9 | 2021-12-09 | Monmouth (46) | 83 | 88 | St. John's (88) | Final | W | 5 |
| 10 | 2021-12-12 | Colgate (239) | 64 | 82 | St. John's (12) | Final | W | 18 |
| 11 | 2021-12-18 | St. John's (12) | 57 | 59 | Pittsburgh (108) | Final | L | -2 |
| 12 | 2021-12-18 | Pittsburgh (226) | 59 | 57 | St. John's (59) | Final | L | -2 |
| 13 | 2021-12-20 | St. John's (12) | 0 | 0 | Seton Hall (53) | Postponed | - | - |
| 14 | 2021-12-23 | Butler (80) | 0 | 0 | St. John's (12) | Postponed | - | - |
| 15 | 2021-12-29 | Marquette (106) | 0 | 0 | St. John's (12) | Cancelled | - | - |
| 16 | 2022-01-01 | St. John's (12) | 0 | 0 | Georgetown (83) | Canceled | - | - |
| 17 | 2022-01-05 | DePaul (95) | 84 | 89 | St. John's (12) | Final | W | 5 |
| 18 | 2022-01-08 | St. John's (12) | 73 | 83 | Providence (82) | Final | L | -10 |
| 19 | 2022-01-12 | St. John's (76) | 78 | 86 | Connecticut (25) | Final (OT) | L | -8 |
| 20 | 2022-01-16 | Georgetown (168) | 69 | 88 | St. John's (73) | Final | W | 19 |
| 21 | 2022-01-19 | St. John's (12) | 64 | 87 | Creighton (78) | Final | L | -23 |
| 22 | 2022-01-22 | Seton Hall (53) | 66 | 60 | St. John's (12) | Final | L | -6 |
| 23 | 2022-01-24 | St. John's (12) | 84 | 63 | Seton Hall (53) | Final | W | 21 |
| 24 | 2022-01-29 | St. John's (12) | 62 | 73 | Villanova (29) | Final | L | -11 |
| 25 | 2022-02-01 | Providence (10) | 86 | 82 | St. John's (83) | Final | L | -4 |
| 26 | 2022-02-03 | St. John's (12) | 90 | 77 | Georgetown (83) | Final | W | 13 |
| 27 | 2022-02-05 | St. John's (12) | 75 | 72 | Butler (80) | Final | W | 3 |
| 28 | 2022-02-08 | Villanova (13) | 75 | 69 | St. John's (76) | Final | L | -6 |
| 29 | 2022-02-13 | Connecticut (24) | 63 | 60 | St. John's (85) | Final | L | -3 |
| 30 | 2022-02-16 | St. John's (85) | 86 | 73 | Xavier (25) | Final | W | 13 |
| 31 | 2022-02-18 | Butler (108) | 57 | 91 | St. John's (85) | Final | W | 34 |
| 32 | 2022-02-23 | Creighton (41) | 81 | 78 | St. John's (60) | Final | L | -3 |
| 33 | 2022-02-27 | St. John's (73) | 94 | 99 | DePaul (93) | Final | L | -5 |
| 34 | 2022-03-02 | Xavier (35) | 66 | 81 | St. John's (73) | Final | W | 15 |
| 35 | 2022-03-05 | St. John's (73) | 77 | 85 | Marquette (30) | Final | L | -8 |
| 36 | 2022-03-09 | DePaul (84) | 73 | 92 | St. John's (71) | Final | W | 19 |
| 37 | 2022-03-10 | St. John's (71) | 65 | 66 | Villanova (8) | Final | L | -1 |