Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Cazenovia | 55 | 95 | Niagara (221) | Final | W | 40 |
| 2 | 2021-11-09 | Niagara (221) | 60 | 63 | Xavier (59) | Final | L | -3 |
| 3 | 2021-11-12 | Niagara (342) | 74 | 84 | Ohio State (34) | Final | L | -10 |
| 4 | 2021-11-19 | Niagara (342) | 70 | 60 | SIU-Edwardsville (248) | Final | W | 10 |
| 5 | 2021-11-20 | Niagara (342) | 67 | 76 | St. Thomas (137) | Final | L | -9 |
| 6 | 2021-11-20 | St. Thomas (163) | 76 | 67 | Niagara (274) | Final | L | -9 |
| 7 | 2021-11-21 | Niagara (204) | 58 | 53 | Youngstown State (237) | Final | W | 5 |
| 8 | 2021-11-29 | Niagara (207) | 70 | 59 | Colgate (166) | Final | W | 11 |
| 9 | 2021-12-03 | Monmouth (176) | 57 | 49 | Niagara (342) | Final | L | -8 |
| 10 | 2021-12-05 | Fairfield (205) | 81 | 71 | Niagara (207) | Final | L | -10 |
| 11 | 2021-12-08 | Niagara (197) | 58 | 60 | Eastern Michigan (244) | Final | L | -2 |
| 12 | 2021-12-12 | Buffalo State | 52 | 112 | Niagara (342) | Final | W | 60 |
| 13 | 2021-12-18 | Albany (330) | 58 | 66 | Niagara (342) | Final | W | 8 |
| 14 | 2021-12-21 | Niagara (342) | 0 | 0 | Binghamton (359) | Cancelled | - | - |
| 15 | 2021-12-31 | Niagara (342) | 68 | 77 | Quinnipiac (189) | Final | L | -9 |
| 16 | 2022-01-02 | Niagara (342) | 0 | 0 | Manhattan (307) | Postponed | - | - |
| 17 | 2022-01-09 | Quinnipiac (220) | 66 | 76 | Niagara (202) | Final | W | 10 |
| 18 | 2022-01-13 | Canisius (328) | 58 | 68 | Niagara (342) | Final | W | 10 |
| 19 | 2022-01-16 | Niagara (200) | 55 | 78 | Iona (38) | Final | L | -23 |
| 20 | 2022-01-18 | Niagara (342) | 72 | 63 | Manhattan (307) | Final | W | 9 |
| 21 | 2022-01-21 | Saint Peter's (223) | 74 | 68 | Niagara (200) | Final (OT) | L | -6 |
| 22 | 2022-01-23 | Rider (302) | 70 | 67 | Niagara (220) | Final | L | -3 |
| 23 | 2022-01-28 | Niagara (220) | 56 | 60 | Siena (243) | Final | L | -4 |
| 24 | 2022-01-30 | Niagara (216) | 70 | 69 | Monmouth (117) | Final | W | 1 |
| 25 | 2022-02-04 | Manhattan (192) | 74 | 80 | Niagara (216) | Final (OT) | W | 6 |
| 26 | 2022-02-06 | Iona (220) | 71 | 80 | Niagara (342) | Final | W | 9 |
| 27 | 2022-02-12 | Niagara (342) | 53 | 73 | Fairfield (204) | Final | L | -20 |
| 28 | 2022-02-14 | Niagara (342) | 70 | 77 | Marist (178) | Final | L | -7 |
| 29 | 2022-02-19 | Niagara (206) | 65 | 54 | Canisius (269) | Final | W | 11 |
| 30 | 2022-02-25 | Niagara (209) | 68 | 70 | Rider (270) | Final | L | -2 |
| 31 | 2022-02-27 | Niagara (225) | 36 | 63 | Saint Peter's (156) | Final | L | -27 |
| 32 | 2022-03-03 | Siena (186) | 52 | 74 | Niagara (225) | Final | W | 22 |
| 33 | 2022-03-05 | Marist (197) | 52 | 83 | Niagara (225) | Final | W | 31 |
| 34 | 2022-03-10 | Niagara (208) | 58 | 61 | Monmouth (135) | Final | L | -3 |