Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-30 | Tiffin | 84 | 94 | Butler (115) | Final | W | 10 |
| 2 | 2021-11-05 | Indianapolis | 68 | 73 | Butler (115) | Final | W | 5 |
| 3 | 2021-11-09 | IUPUI (263) | 47 | 56 | Butler (115) | Final | W | 9 |
| 4 | 2021-11-12 | Central Arkansas (143) | 53 | 85 | Butler (80) | Final | W | 32 |
| 5 | 2021-11-13 | Troy (252) | 59 | 70 | Butler (115) | Final | W | 11 |
| 6 | 2021-11-17 | Michigan State (10) | 73 | 52 | Butler (80) | Final | L | -21 |
| 7 | 2021-11-22 | Butler (80) | 52 | 70 | Houston (5) | Final | L | -18 |
| 8 | 2021-11-23 | Texas A&M (38) | 57 | 50 | Butler (118) | Final | L | -7 |
| 9 | 2021-11-24 | Butler (80) | 84 | 51 | Chaminade | Final | W | 33 |
| 10 | 2021-11-30 | Saginaw Valley | 57 | 68 | Butler (158) | Final | W | 11 |
| 11 | 2021-12-07 | Butler (80) | 66 | 62 | Oklahoma (47) | Final/OT | W | 4 |
| 12 | 2021-12-11 | Eastern Illinois (314) | 54 | 66 | Butler (80) | Final | W | 12 |
| 13 | 2021-12-18 | Purdue (8) | 77 | 48 | Butler (80) | Final | L | -29 |
| 14 | 2021-12-23 | Butler (80) | 0 | 0 | St. John's (12) | Postponed | - | - |
| 15 | 2021-12-29 | DePaul (95) | 59 | 63 | Butler (80) | Final | W | 4 |
| 16 | 2022-01-01 | Butler (80) | 0 | 0 | Connecticut (4) | Postponed | - | - |
| 17 | 2022-01-04 | Seton Hall (53) | 71 | 56 | Butler (80) | Final | L | -15 |
| 18 | 2022-01-07 | Xavier (92) | 87 | 72 | Butler (80) | Final | L | -15 |
| 19 | 2022-01-13 | Butler (80) | 72 | 58 | Georgetown (83) | Final | W | 14 |
| 20 | 2022-01-16 | Butler (111) | 42 | 82 | Villanova (11) | Final | L | -40 |
| 21 | 2022-01-18 | Butler (80) | 59 | 76 | Connecticut (4) | Final | L | -17 |
| 22 | 2022-01-20 | Connecticut (4) | 75 | 56 | Butler (80) | Final | L | -19 |
| 23 | 2022-01-23 | Butler (123) | 62 | 69 | Providence (13) | Final | L | -7 |
| 24 | 2022-01-26 | Creighton (44) | 55 | 72 | Butler (123) | Final | W | 17 |
| 25 | 2022-01-29 | Georgetown (83) | 53 | 56 | Butler (80) | Final | W | 3 |
| 26 | 2022-02-02 | Butler (109) | 66 | 68 | Xavier (18) | Final | L | -2 |
| 27 | 2022-02-05 | St. John's (12) | 75 | 72 | Butler (80) | Final | L | -3 |
| 28 | 2022-02-08 | Butler (114) | 52 | 54 | Creighton (59) | Final | L | -2 |
| 29 | 2022-02-12 | Marquette (106) | 79 | 85 | Butler (80) | Final | W | 6 |
| 30 | 2022-02-15 | Butler (108) | 73 | 71 | DePaul (88) | Final | W | 2 |
| 31 | 2022-02-18 | Butler (108) | 57 | 91 | St. John's (85) | Final | L | -34 |
| 32 | 2022-02-20 | Providence (11) | 71 | 70 | Butler (112) | Final | L | -1 |
| 33 | 2022-02-23 | Butler (112) | 60 | 66 | Seton Hall (33) | Final | L | -6 |
| 34 | 2022-02-26 | Butler (112) | 56 | 64 | Marquette (30) | Final | L | -8 |
| 35 | 2022-03-05 | Villanova (14) | 78 | 59 | Butler (112) | Final | L | -19 |
| 36 | 2022-03-09 | Butler (114) | 89 | 82 | Xavier (38) | Final | W | 7 |
| 37 | 2022-03-10 | Butler (114) | 61 | 65 | Providence (10) | Final | L | -4 |