Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-13 | Dartmouth | 69 | 60 | Georgetown (63) | Final | L | -9 |
| 2 | 2021-11-16 | American (66) | 57 | 79 | Georgetown (275) | Final | W | 22 |
| 3 | 2021-11-19 | Siena (160) | 65 | 83 | Georgetown (83) | Final | W | 18 |
| 4 | 2021-11-25 | Georgetown (83) | 56 | 73 | San Diego State (48) | Final | L | -17 |
| 5 | 2021-11-26 | Saint Joseph's (99) | 77 | 74 | Georgetown (83) | Final | L | -3 |
| 6 | 2021-11-26 | Georgetown (153) | 56 | 73 | San Diego State (99) | Final | L | -17 |
| 7 | 2021-11-30 | Longwood (201) | 83 | 91 | Georgetown (236) | Final | W | 8 |
| 8 | 2021-12-05 | Georgetown (236) | 67 | 80 | South Carolina (52) | Final | L | -13 |
| 9 | 2021-12-08 | UMBC (179) | 71 | 100 | Georgetown (220) | Final | W | 29 |
| 10 | 2021-12-11 | Syracuse (84) | 75 | 79 | Georgetown (83) | Final | W | 4 |
| 11 | 2021-12-15 | Howard (211) | 73 | 85 | Georgetown (83) | Final | W | 12 |
| 12 | 2021-12-18 | TCU (32) | 80 | 73 | Georgetown (83) | Final | L | -7 |
| 13 | 2021-12-22 | Georgetown (83) | 0 | 0 | Providence (82) | Postponed | - | - |
| 14 | 2021-12-28 | Georgetown (83) | 0 | 0 | Creighton (78) | Postponed | - | - |
| 15 | 2022-01-01 | St. John's (12) | 0 | 0 | Georgetown (83) | Canceled | - | - |
| 16 | 2022-01-04 | Xavier (92) | 0 | 0 | Georgetown (83) | Canceled | - | - |
| 17 | 2022-01-07 | Marquette (106) | 92 | 64 | Georgetown (83) | Final | L | -28 |
| 18 | 2022-01-13 | Butler (80) | 72 | 58 | Georgetown (83) | Final | L | -14 |
| 19 | 2022-01-16 | Georgetown (168) | 69 | 88 | St. John's (73) | Final | L | -19 |
| 20 | 2022-01-20 | Georgetown (83) | 75 | 83 | Providence (82) | Final | L | -8 |
| 21 | 2022-01-22 | Villanova (29) | 85 | 74 | Georgetown (83) | Final | L | -11 |
| 22 | 2022-01-25 | Georgetown (178) | 73 | 96 | Connecticut (19) | Final | L | -23 |
| 23 | 2022-01-29 | Georgetown (83) | 53 | 56 | Butler (80) | Final | L | -3 |
| 24 | 2022-02-01 | Seton Hall (44) | 70 | 63 | Georgetown (185) | Final | L | -7 |
| 25 | 2022-02-03 | St. John's (12) | 90 | 77 | Georgetown (83) | Final | L | -13 |
| 26 | 2022-02-06 | Providence (82) | 71 | 52 | Georgetown (83) | Final | L | -19 |
| 27 | 2022-02-09 | Georgetown (83) | 74 | 82 | DePaul (95) | Final | L | -8 |
| 28 | 2022-02-12 | Creighton (78) | 80 | 66 | Georgetown (83) | Final | L | -14 |
| 29 | 2022-02-14 | Georgetown (83) | 77 | 88 | Creighton (78) | Final | L | -11 |
| 30 | 2022-02-16 | Georgetown (204) | 66 | 77 | Marquette (29) | Final | L | -11 |
| 31 | 2022-02-19 | Georgetown (204) | 66 | 74 | Villanova (9) | Final | L | -8 |
| 32 | 2022-02-24 | DePaul (102) | 68 | 65 | Georgetown (201) | Final | L | -3 |
| 33 | 2022-02-27 | Connecticut (16) | 86 | 77 | Georgetown (205) | Final | L | -9 |
| 34 | 2022-03-02 | Georgetown (205) | 68 | 73 | Seton Hall (31) | Final | L | -5 |
| 35 | 2022-03-05 | Georgetown (205) | 75 | 97 | Xavier (35) | Final | L | -22 |
| 36 | 2022-03-09 | Georgetown (205) | 53 | 57 | Seton Hall (27) | Final | L | -4 |