Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-04 | Kentucky State | 0 | 0 | Morehead State (103) | Cancelled | - | - |
| 2 | 2021-11-09 | Morehead State (103) | 54 | 77 | Auburn (71) | Final | L | -23 |
| 3 | 2021-11-12 | Morehead State (233) | 71 | 85 | UAB (115) | Final | L | -14 |
| 4 | 2021-11-15 | Kentucky Christian | 57 | 82 | Morehead State (302) | Final | W | 25 |
| 5 | 2021-11-18 | Transylvania | 59 | 84 | Morehead State (302) | Final | W | 25 |
| 6 | 2021-11-21 | Morehead State (279) | 46 | 66 | Mississippi State (41) | Final | L | -20 |
| 7 | 2021-11-26 | Morehead State (233) | 75 | 51 | Arkansas State (147) | Final | W | 24 |
| 8 | 2021-11-27 | UMKC (124) | 62 | 70 | Morehead State (279) | Final | W | 8 |
| 9 | 2021-12-01 | Georgia Southern (216) | 51 | 59 | Morehead State (233) | Final | W | 8 |
| 10 | 2021-12-06 | Presbyterian (156) | 66 | 71 | Morehead State (136) | Final | W | 5 |
| 11 | 2021-12-11 | Morehead State (233) | 75 | 82 | East Tennessee State (140) | Final | L | -7 |
| 12 | 2021-12-15 | Morehead State (233) | 63 | 86 | Xavier (92) | Final | L | -23 |
| 13 | 2021-12-18 | Alice Lloyd | 47 | 87 | Morehead State (233) | Final | W | 40 |
| 14 | 2021-12-21 | Morehead State (233) | 80 | 52 | IU-Indy (338) | Final | W | 28 |
| 15 | 2021-12-21 | Morehead State (146) | 80 | 52 | IUPUI (357) | Final | W | 28 |
| 16 | 2021-12-29 | Eastern Illinois (314) | 50 | 63 | Morehead State (233) | Final | W | 13 |
| 17 | 2022-01-01 | Tennessee State (165) | 0 | 0 | Morehead State (233) | Postponed | - | - |
| 18 | 2022-01-08 | Morehead State (233) | 66 | 55 | Austin Peay (138) | Final | W | 11 |
| 19 | 2022-01-12 | Tennessee-Martin (271) | 62 | 76 | Morehead State (139) | Final | W | 14 |
| 20 | 2022-01-15 | Morehead State (233) | 71 | 64 | Tennessee State (165) | Final | W | 7 |
| 21 | 2022-01-20 | Belmont (68) | 74 | 83 | Morehead State (233) | Final | W | 9 |
| 22 | 2022-01-22 | SIU-Edwardsville (248) | 74 | 77 | Morehead State (233) | Final | W | 3 |
| 23 | 2022-01-24 | Tennessee State (165) | 54 | 67 | Morehead State (233) | Final | W | 13 |
| 24 | 2022-01-27 | Morehead State (233) | 74 | 73 | Southeast Missouri State (226) | Final/OT | W | 1 |
| 25 | 2022-01-29 | Morehead State (233) | 66 | 77 | Murray State (116) | Final | L | -11 |
| 26 | 2022-01-31 | Morehead State (122) | 70 | 56 | Tennessee Tech (285) | Final | W | 14 |
| 27 | 2022-02-03 | Tennessee Tech (310) | 68 | 75 | Morehead State (233) | Final | W | 7 |
| 28 | 2022-02-05 | Austin Peay (138) | 52 | 77 | Morehead State (233) | Final | W | 25 |
| 29 | 2022-02-10 | Morehead State (233) | 47 | 48 | Belmont (68) | Final | L | -1 |
| 30 | 2022-02-12 | Murray State (116) | 57 | 53 | Morehead State (233) | Final | L | -4 |
| 31 | 2022-02-16 | Morehead State (116) | 68 | 60 | Tennessee-Martin (321) | Final | W | 8 |
| 32 | 2022-02-19 | Southeast Missouri State (302) | 92 | 84 | Morehead State (116) | Final | L | -8 |
| 33 | 2022-02-24 | Morehead State (131) | 82 | 46 | Eastern Illinois (353) | Final | W | 36 |
| 34 | 2022-02-26 | Morehead State (131) | 70 | 77 | SIU-Edwardsville (310) | Final | L | -7 |
| 35 | 2022-03-03 | Tennessee Tech (289) | 56 | 73 | Morehead State (146) | Final | W | 17 |
| 36 | 2022-03-04 | Morehead State (146) | 53 | 51 | Belmont (58) | Final | W | 2 |
| 37 | 2022-03-05 | Morehead State (146) | 67 | 71 | Murray State (22) | Final | L | -4 |