Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-10-23 | St. Francis (IL) | 34 | 101 | Illinois (3) | Final | W | 67 |
| 2 | 2021-10-29 | Indiana (PA) | 79 | 94 | Illinois (3) | Final | W | 15 |
| 3 | 2021-11-09 | Jackson State (234) | 47 | 71 | Illinois (3) | Final | W | 24 |
| 4 | 2021-11-12 | Arkansas State (147) | 53 | 92 | Illinois (9) | Final | W | 39 |
| 5 | 2021-11-15 | Illinois (39) | 66 | 67 | Marquette (78) | Final | L | -1 |
| 6 | 2021-11-22 | Illinois (9) | 51 | 71 | Cincinnati (54) | Final | L | -20 |
| 7 | 2021-11-23 | Illinois (95) | 72 | 64 | Kansas State (119) | Final | W | 8 |
| 8 | 2021-11-26 | UTRGV (161) | 85 | 94 | Illinois (9) | Final | W | 9 |
| 9 | 2021-11-29 | Notre Dame (142) | 72 | 82 | Illinois (87) | Final | W | 10 |
| 10 | 2021-12-03 | Rutgers (112) | 51 | 86 | Illinois (9) | Final | W | 35 |
| 11 | 2021-12-06 | Illinois (53) | 87 | 83 | Iowa (23) | Final | W | 4 |
| 12 | 2021-12-11 | Arizona (2) | 83 | 79 | Illinois (9) | Final | L | -4 |
| 13 | 2021-12-18 | St. Francis (PA) (286) | 48 | 106 | Illinois (43) | Final | W | 58 |
| 14 | 2021-12-22 | Missouri (51) | 63 | 88 | Illinois (9) | Final | W | 25 |
| 15 | 2021-12-29 | Florida A&M (297) | 0 | 0 | Illinois (9) | Cancelled | - | - |
| 16 | 2022-01-04 | Illinois (9) | 76 | 53 | Minnesota (87) | Final | W | 23 |
| 17 | 2022-01-06 | Maryland (114) | 64 | 76 | Illinois (9) | Final | W | 12 |
| 18 | 2022-01-11 | Illinois (9) | 81 | 71 | Nebraska (13) | Final | W | 10 |
| 19 | 2022-01-14 | Michigan (77) | 53 | 68 | Illinois (23) | Final | W | 15 |
| 20 | 2022-01-17 | Purdue (9) | 96 | 88 | Illinois (17) | Final | L | -8 |
| 21 | 2022-01-21 | Illinois (17) | 65 | 81 | Maryland (100) | Final | L | -16 |
| 22 | 2022-01-25 | Michigan State (9) | 55 | 56 | Illinois (25) | Final | W | 1 |
| 23 | 2022-01-29 | Illinois (9) | 59 | 56 | Northwestern (75) | Final | W | 3 |
| 24 | 2022-02-02 | Wisconsin (9) | 67 | 80 | Illinois (21) | Final | W | 13 |
| 25 | 2022-02-05 | Illinois (9) | 74 | 57 | Indiana (46) | Final | W | 17 |
| 26 | 2022-02-08 | Illinois (15) | 68 | 84 | Purdue (6) | Final | L | -16 |
| 27 | 2022-02-13 | Northwestern (80) | 66 | 73 | Illinois (16) | Final | W | 7 |
| 28 | 2022-02-16 | Illinois (16) | 59 | 70 | Rutgers (75) | Final | L | -11 |
| 29 | 2022-02-19 | Illinois (16) | 79 | 74 | Michigan State (18) | Final | W | 5 |
| 30 | 2022-02-24 | Ohio State (24) | 86 | 83 | Illinois (16) | Final | L | -3 |
| 31 | 2022-02-27 | Illinois (20) | 93 | 85 | Michigan (45) | Final | W | 8 |
| 32 | 2022-03-03 | Penn State (94) | 55 | 60 | Illinois (20) | Final | W | 5 |
| 33 | 2022-03-06 | Iowa (25) | 72 | 74 | Illinois (17) | Final | W | 2 |
| 34 | 2022-03-11 | Indiana (54) | 65 | 63 | Illinois (17) | Final | L | -2 |
| 35 | 2022-03-18 | Chattanooga (65) | 53 | 54 | Illinois (19) | Final | W | 1 |
| 36 | 2022-03-20 | Houston (9) | 68 | 53 | Illinois (19) | Final | L | -15 |