Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-06 | Kalamazoo | 47 | 77 | Western Michigan (307) | Final | W | 30 |
| 2 | 2021-11-10 | Hope | 58 | 76 | Western Michigan (307) | Final | W | 18 |
| 3 | 2021-11-12 | Western Michigan (304) | 46 | 90 | Michigan State (10) | Final | L | -44 |
| 4 | 2021-11-18 | Saginaw Valley | 80 | 63 | Western Michigan (317) | Final | L | -17 |
| 5 | 2021-11-22 | Western Michigan (304) | 61 | 109 | Iowa (28) | Final | L | -48 |
| 6 | 2021-11-26 | Western Michigan (304) | 67 | 77 | Florida Gulf Coast (241) | Final | L | -10 |
| 7 | 2021-11-27 | Purdue Fort Wayne (151) | 85 | 93 | Western Michigan (356) | Final (OT) | W | 8 |
| 8 | 2021-11-28 | Western Michigan (309) | 81 | 77 | Southeastern Louisiana (329) | Final (OT) | W | 4 |
| 9 | 2021-12-05 | Valparaiso (259) | 71 | 60 | Western Michigan (309) | Final | L | -11 |
| 10 | 2021-12-11 | Western Michigan (304) | 64 | 83 | Detroit (212) | Final | L | -19 |
| 11 | 2021-12-17 | Aquinas | 56 | 67 | Western Michigan (304) | Final | W | 11 |
| 12 | 2021-12-20 | Western Michigan (304) | 52 | 85 | Notre Dame (101) | Final | L | -33 |
| 13 | 2021-12-29 | Western Michigan (304) | 56 | 83 | Toledo (135) | Final | L | -27 |
| 14 | 2022-01-01 | Ohio (218) | 59 | 47 | Western Michigan (304) | Final | L | -12 |
| 15 | 2022-01-04 | Eastern Michigan (277) | 85 | 79 | Western Michigan (304) | Final | L | -6 |
| 16 | 2022-01-08 | Western Michigan (304) | 0 | 0 | Central Michigan (311) | Postponed | - | - |
| 17 | 2022-01-11 | Buffalo (219) | 78 | 64 | Western Michigan (304) | Final | L | -14 |
| 18 | 2022-01-15 | Miami (OH) (40) | 70 | 62 | Western Michigan (304) | Final | L | -8 |
| 19 | 2022-01-18 | Western Michigan (304) | 73 | 74 | Akron (59) | Final | L | -1 |
| 20 | 2022-01-20 | Western Michigan (304) | 0 | 0 | Central Michigan (311) | Postponed | - | - |
| 21 | 2022-01-22 | Bowling Green (168) | 82 | 75 | Western Michigan (304) | Final | L | -7 |
| 22 | 2022-01-25 | Western Michigan (342) | 64 | 75 | Kent State (179) | Final | L | -11 |
| 23 | 2022-01-29 | Western Michigan (304) | 72 | 83 | Ball State (298) | Final | L | -11 |
| 24 | 2022-02-01 | Northern Illinois (291) | 75 | 56 | Western Michigan (345) | Final | L | -19 |
| 25 | 2022-02-03 | Western Michigan (304) | 55 | 65 | Central Michigan (311) | Final | L | -10 |
| 26 | 2022-02-05 | Western Michigan (304) | 64 | 77 | Ohio (218) | Final | L | -13 |
| 27 | 2022-02-08 | Western Michigan (350) | 57 | 62 | Miami (OH) (268) | Final | L | -5 |
| 28 | 2022-02-12 | Central Michigan (311) | 63 | 77 | Western Michigan (304) | Final | W | 14 |
| 29 | 2022-02-15 | Akron (128) | 57 | 61 | Western Michigan (346) | Final (OT) | W | 4 |
| 30 | 2022-02-19 | Western Michigan (346) | 73 | 87 | Buffalo (132) | Final | L | -14 |
| 31 | 2022-02-22 | Toledo (79) | 92 | 50 | Western Michigan (342) | Final | L | -42 |
| 32 | 2022-02-26 | Western Michigan (342) | 78 | 67 | Bowling Green (253) | Final | W | 11 |
| 33 | 2022-03-01 | Western Michigan (335) | 71 | 60 | Eastern Michigan (283) | Final | W | 11 |
| 34 | 2022-03-04 | Ball State (252) | 64 | 63 | Western Michigan (335) | Final | L | -1 |