Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Bowie State | 0 | 0 | Howard (333) | Cancelled | - | - |
| 2 | 2021-11-09 | District of Columbia | 59 | 87 | Howard (333) | Final | W | 28 |
| 3 | 2021-11-10 | Regent | 54 | 118 | Howard (333) | Final | W | 64 |
| 4 | 2021-11-13 | Howard (333) | 76 | 64 | Bradley (181) | Final | W | 12 |
| 5 | 2021-11-16 | Howard (103) | 81 | 100 | Villanova (123) | Final | L | -19 |
| 6 | 2021-11-20 | Howard (211) | 63 | 73 | High Point (69) | Final | L | -10 |
| 7 | 2021-11-21 | Howard (211) | 82 | 76 | William & Mary (352) | Final | W | 6 |
| 8 | 2021-11-26 | Austin Peay (138) | 69 | 67 | Howard (211) | Final | L | -2 |
| 9 | 2021-11-30 | Howard (245) | 70 | 72 | Mount St Mary's (292) | Final | L | -2 |
| 10 | 2021-12-04 | American (249) | 56 | 90 | Howard (211) | Final | W | 34 |
| 11 | 2021-12-15 | Howard (211) | 73 | 85 | Georgetown (83) | Final | L | -12 |
| 12 | 2021-12-18 | North Carolina A&T (294) | 57 | 79 | Howard (211) | Final | W | 22 |
| 13 | 2021-12-21 | Howard (211) | 69 | 77 | Harvard (181) | Final | L | -8 |
| 14 | 2021-12-23 | Howard (211) | 0 | 0 | Yale (81) | Cancelled | - | - |
| 15 | 2021-12-30 | Howard (211) | 0 | 0 | Hampton (260) | Cancelled | - | - |
| 16 | 2022-01-04 | Howard (211) | 0 | 0 | Penn (131) | Canceled | - | - |
| 17 | 2022-01-08 | Howard (211) | 0 | 0 | Delaware State (361) | Postponed | - | - |
| 18 | 2022-01-15 | Norfolk State (322) | 77 | 74 | Howard (211) | Final | L | -3 |
| 19 | 2022-01-17 | Notre Dame (85) | 71 | 68 | Howard (263) | Final | L | -3 |
| 20 | 2022-01-22 | Howard (211) | 91 | 82 | Morgan State (337) | Final | W | 9 |
| 21 | 2022-01-24 | Howard (211) | 81 | 83 | Coppin State (360) | Final | L | -2 |
| 22 | 2022-01-29 | Howard (211) | 75 | 74 | North Carolina Central (341) | Final/OT | W | 1 |
| 23 | 2022-01-31 | Howard (253) | 55 | 58 | South Carolina State (297) | Final | L | -3 |
| 24 | 2022-02-05 | Maryland-Eastern Shore (353) | 64 | 72 | Howard (211) | Final | W | 8 |
| 25 | 2022-02-07 | Howard (211) | 69 | 64 | Delaware State (361) | Final | W | 5 |
| 26 | 2022-02-08 | Gallaudet | 38 | 96 | Howard (255) | Final | W | 58 |
| 27 | 2022-02-12 | Delaware State (361) | 72 | 85 | Howard (211) | Final | W | 13 |
| 28 | 2022-02-14 | Howard (211) | 77 | 71 | Maryland-Eastern Shore (353) | Final | W | 6 |
| 29 | 2022-02-19 | Morgan State (332) | 66 | 68 | Howard (250) | Final | W | 2 |
| 30 | 2022-02-21 | Coppin State (322) | 86 | 82 | Howard (240) | Final | L | -4 |
| 31 | 2022-02-26 | North Carolina Central (250) | 67 | 77 | Howard (240) | Final | W | 10 |
| 32 | 2022-02-28 | South Carolina State (290) | 62 | 72 | Howard (243) | Final | W | 10 |
| 33 | 2022-03-03 | Howard (243) | 61 | 83 | Norfolk State (171) | Final | L | -22 |
| 34 | 2022-03-09 | Coppin State (319) | 59 | 57 | Howard (243) | Final | L | -2 |